VTCN1

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VTCN1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1
External IDs MGI: 3039619 HomoloGene: 11627 GeneCards: VTCN1
Genetically Related Diseases
juvenile rheumatoid arthritis[1]
RNA expression pattern
PBB GE VTCN1 219768 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253849
NM_001253850
NM_024626

NM_178594

RefSeq (protein)

NP_001240778
NP_001240779
NP_078902

NP_848709.2
NP_848709

Location (UCSC) Chr 1: 117.14 – 117.21 Mb Chr 3: 100.83 – 100.9 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.[4][5][6]

Function[edit]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][6]

B7-H4 is an immune checkpoint molecule.

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with VTCN1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165. 
  5. ^ Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166. 
  6. ^ a b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1". 

Further reading[edit]