CD86

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CD86
CD86 structure.gif
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
External IDs OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CD86
Genomic location for CD86
Band 3q13.33 Start 122,055,366 bp[1]
End 122,121,139 bp[1]
RNA expression pattern
PBB GE CD86 210895 s at fs.png

PBB GE CD86 205685 at fs.png

PBB GE CD86 205686 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_176892
NM_001206924
NM_001206925
NM_006889
NM_175862

NM_019388

RefSeq (protein)

NP_001193853
NP_001193854
NP_008820
NP_787058
NP_795711

NP_062261

Location (UCSC) Chr 3: 122.06 – 122.12 Mb Chr 3: 36.6 – 36.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.[5] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114013 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022901 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". Journal of Immunology. 152 (10): 4929–36. PMID 7513726. 
  6. ^ "Entrez Gene: CD86 CD86 molecule". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.