Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
The CD86gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
^Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol.152 (10): 4929–36. PMID7513726.
Dalla-Costa R, Pincerati MR, Beltrame MH, et al. (2010). "Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus". Hum. Immunol.71 (8): 809–17. doi:10.1016/j.humimm.2010.04.001. PMID20433886.
Kim SH, Lee JE, Kim SH, et al. (2009). "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions". Clin. Exp. Allergy39 (12): 1852–6. doi:10.1111/j.1365-2222.2009.03336.x. PMID19735272.
Ma XN, Wang X, Yan YY, et al. (2010). "Absence of association between CD86 +1057G/A polymorphism and coronary artery disease". DNA Cell Biol.29 (6): 325–8. doi:10.1089/dna.2009.0987. PMID20230296.
Ishizaki Y, Yukaya N, Kusuhara K, et al. (2010). "PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis". Human Genetics127 (4): HASH(0x31b6c40). doi:10.1007/s00439-009-0781-z. PMID20066438.
Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun.5: 113–30. doi:10.1159/000060550. PMID11826754.
Grujic M, Bartholdy C, Remy M, et al. (2010). "The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus". J. Immunol.185 (3): 1730–43. doi:10.4049/jimmunol.0903894. PMID20601595.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J.20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID17077296.
Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol.45 (6): 608–13. doi:10.1002/ppul.21229. PMID20503287.