Von Graefe's sign
Von Graefe's sign is the lagging of the upper eyelid on downward rotation of the eye, indicating exophthalmic goiter (Graves' Disease). It is a dynamic sign, whereas lid lag is a static sign which may also be present in cicatricial eyelid retraction or congenital ptosis.
A pseudo Graefe's sign (pseudo lid lag) shows a similar lag, but is due to aberrant regeneration of fibres of the oculomotor nerve (III) into the elevator of the upper lid. It occurs in paramyotonia congenita. A pseudo Graefe's sign is most commonly manifested in just one eye but can occasionally be observed in both. The reason only one eye is affected is not yet clear.
- Albrecht von Gräfe
- Boston's sign
- Griffith's sign
- Graves orbitopathy
- Hyperthyroidism, as lid lag may be in hyperthyroid patients lacking Graves' disease.
- Cline D; Hofstetter HW; Griffin JR. Dictionary of Visual Science. 4th ed. Butterworth-Heinemann, Boston 1997. ISBN 0-7506-9895-0
- Definition: pseudo-Graefe sign from Online Medical Dictionary
- Fowler, Timothy J.; John W. Scadding (2003). Clinical Neurology 3rd ed. p. 145. ISBN 0-340-80798-9.
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