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New and updated Cochrane Systematic Reviews are published every week. Prior to publication, each new review is discussed at a weekly Analysis of Review Group Output (ARGO) meeting by a group of health and communications specialists at Cochrane UK. The Cochrane reviews listed here are those that have been flagged up during this meeting as being of particular strength, importance, and interest to benefit the evidence base of health-related articles on Wikipedia.

This table presents key information about these reviews to anyone wishing to develop Wikipedia medicine articles with Cochrane evidence. Part of the table is updating weekly by someone at Cochrane UK, the other part is where interested users can help link and develop relevant articles on Wikipedia.

Recent Cochrane Reviews

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Updated weekly Please edit
# Review Group Review Research Question Conclusions Date of Publication DOI Suggested Article(s) Action


1

Renal

This review aimed to assess the effectiveness and complications of ESWL for kidney stones compared with PCNL or RIRS. Changed 2014/11 10.1002/14651858.CD007044.pub3 Extracorporeal shock wave lithotripsy checkY

2

Occupational Safety & Health

To evaluate the effectiveness of interventions aimed at reducing work disability in employees with depressive disorders. Changed 2014/12 10.1002/14651858.CD006237.pub3 Mood disorder

3

Depression, Anxiety & Neurosis

To evaluate the effectiveness of psychological therapies and antidepressant medication, alone and in combination, for the treatment of depressive disorder in children and adolescents. Unchanged 2014/11 10.1002/14651858.CD008324.pub3 Major depressive disorder
Depression in childhood and adolescence

4

Heart Group

To conduct an overview of Cochrane systematic reviews to provide a contemporary review of the evidence for delivery of cardiac rehabilitation, to identify opportunities for merging or splitting existing Cochrane reviews, and to identify current evidence gaps to inform new cardiac rehabilitation systematic review titles. New review 2014/12 10.1002/14651858.CD011273.pub2. Cardiopulmonary rehabilitation checkY

5

Pregnancy and Childbirth Group

To assess the effects of all interventions in the resolution or reduction of nipple pain and the impact of the interventions on other outcomes such as nipple trauma, nipple infections, breast mastitis, breastfeeding duration, breastfeeding exclusivity, and maternal satisfaction. New review 2014/12 10.1002/14651858.CD007366.pub2 Breastfeeding difficulties#Nipple_pain Little evidence

6

Menstrual Disorders & Subfertility

To summarise evidence derived from Cochrane systematic reviews on the clinical safety and effectiveness of solid agents, gel agents, liquid agents and pharmacological agents, used as adjuvants to prevent formation of adhesions after gynaecological pelvic surgery. New review 2015/01 10.1002/14651858.CD011254.pub2

7

Pregnancy & Childbirth

To assess the effects of administering antibiotic regimens for intra-amniotic infection on maternal and perinatal morbidity and mortality and on infection-related complications. New review 2014/12 10.1002/14651858.CD010976.pub2 Chorioamnionitis

8

Public Health

To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity. Changed 2015/01 10.1002/14651858.CD008366.pub3 Physical exercise checkY

9

Lung Cancer

To assess the effects of different palliative radiotherapy regimens on improving thoracic symptoms in patients with locally advanced or metastatic non-small cell lung cancer who are not suitable for radical RT given with curative intent. To assess the effects of radiotherapy dose on overall survival in patients with locally advanced or metastatic non-small cell lung cancer who are not suitable for radical RT given with curative intent. Changed 2015/01 10.1002/14651858.CD002143.pub4 Distress_in_cancer_caregiving
Palliative_care
End-of-life_care

10

Hepato-Biliary

To determine the diagnostic accuracy of transient elastography for diagnosis and staging hepatic fibrosis in people with alcoholic liver disease when compared with liver biopsy. To identify the optimal cut-off values for differentiating the five stages of hepatic fibrosis. New review 2015/01 10.1002/14651858.CD010542.pub2 Cirrhosis
Transient elastography
Alcoholic liver disease
Liver biopsy

11

Dementia and Cognitive Improvement Group

The primary objective of this review was to determine the diagnostic accuracy of the Mini-Cog for detecting Alzheimer's disease dementia and related dementias in a community setting. New review 2015/02 10.1002/14651858.CD010860 General_Practitioner_Assessment_of_Cognition Nothing much interesting to report.

12

Depression, Anxiety and Neurosis Group

The objective of this review was to determine the effects of exercise therapy (ET) for patients with Chronic Fatigue Syndrome as compared with any other intervention or control. Unchanged 2015/02 10.1002/14651858.CD003200.pub3 Chronic fatigue syndrome
Exercise therapy

13

Eyes and Vision Group

The objective of this review was to examine the effectiveness of statins compared with other treatments, no treatment, or placebo in delaying the onset and progression of age-related macular degeneration (AMD). Unchanged 2015/02 10.1002/14651858.CD006927.pub4 Statin
Macular degeneration

14

Injuries Group

The objective was to determine the diagnostic accuracy of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy (TIC) in adult trauma patients with bleeding, using a reference standard of prothrombin time ratio and/or the international normalized ratio. New Review 2015/02 10.1002/14651858.CD010438.pub2 Thromboelastography
Coagulopathy

15

Acute Respiratory Infections Group

To determine the effectiveness of repairing buildings damaged by dampness and mould in order to reduce or prevent respiratory tract symptoms, infections and symptoms of asthma. Unchanged 2015/02 10.1002/14651858.CD007897.pub3 Damp_(structural)

16

Pain, Palliative and Supportive Care Group

To assess the effectiveness and tolerability of oxycodone for pain in adults with cancer. New Review 2015/02 10.1002/14651858.CD003870.pub5 Oxycodone
Cancer pain

17

Schizophrenia Group

To examine the clinical effects and safety of perphenazine for those with schizophrenia and schizophrenia-like psychoses. Unchanged 2015/03 10.1002/14651858.CD003443.pub3 Schizophrenia
Perphenazine

18

Acute Respiratory Infections Group

To compare the effectiveness of azithromycin to amoxycillin or amoxycillin/clavulanic acid (amoxyclav) in the treatment of acute lower respiratory tract infections (LRTI), in terms of clinical failure, incidence of adverse events and microbial eradication. Unchanged 2015/03 10.1002/14651858.CD001954.pub4 Lower respiratory tract infection
Azithromycin
Amoxicillin

19

Ear, Nose and Throat Disorders Group

To assess the effects of positive pressure therapy (e.g. the Meniett device) on the symptoms of Ménière's disease or syndrome. New Review 2015/03 10.1002/14651858.CD008419.pub2 Ménière's disease

20

Consumers and Communication Group

To assess the effects of personalised care planning for adults with long-term health conditions compared to usual care (i.e. forms of care in which active involvement of patients in treatment and management decisions is not explicitly attempted or achieved). New Review 2015/03 10.1002/14651858.CD010523.pub2

21

Stroke Group

To determine: (1) whether interventions improve community ambulation for stroke survivors, and (2) if any specific intervention method improves community ambulation more than other interventions. New Review 2015/03 10.1002/14651858.CD010200.pub2 Stroke checkY

22

Heart Group

To assess the effects of hormone therapy for the prevention of cardiovascular disease in post-menopausal women, and whether there are differential effects between use in primary or secondary prevention. Unchanged 2015/03 10.1002/14651858.CD002229.pub4 Hormone replacement therapy (menopause)
Cardiovascular disease

23

Injuries Group

To compare the effect and cost of cell salvage with those of standard care in individuals undergoing abdominal or thoracic trauma surgery. Unchanged 2015/01 10.1002/14651858.CD007379.pub2 Trauma surgery
Intraoperative blood salvage

24

Depression, Anxiety and Neurosis Group

To assess the effects of therapist-supported Internet cognitive behavioural therapy (CBT) on remission of anxiety disorder diagnosis and reduction of anxiety symptoms in adults as compared to waiting list control, unguided CBT, or face-to-face CBT. Effects of treatment on quality of life and patient satisfaction with the intervention were also assessed. Unchanged 2015/01 10.1002/14651858.CD011565 Cognitive behavioral therapy
Anxiety disorder

25

Infectious Diseases Group

To evaluate the efficacy and safety of the artemisinin-naphthoquine combination for treating adults and children with uncomplicated P. falciparum malaria. New Review 2015/02 10.1002/14651858.CD011547 Plasmodium falciparum

26

Musculoskeletal Group

To assess the benefits and harms of braces and foot/ankle orthoses in the treatment of patients with osteoarthritis (OA) of the knee. Unchanged 2015/03 10.1002/14651858.CD004020.pub3 Osteoarthritis checkY

27

Wounds Group

The objective of this review was to assess the effects of honey compared with alternative wound dressings and topical treatments on the of healing of acute (e.g. burns, lacerations) and/or chronic (e.g. venous ulcers) wounds. Changed 2015/03 10.1002/14651858.CD005083.pub4 Honey
Dressing (medical)
Wound
Burn
Venous ulcer
checkY

28

Tobacco Addiction Group

The primary objective of this review was to assess the effectiveness of interventions to increase adherence to medications for smoking cessation, such as NRT, bupropion, nortriptyline and varenicline (and combination regimens). This was considered in comparison to a control group, typically representing standard care. New Review 2015/02 10.1002/14651858.CD009164.pub2 Smoking cessation
Nicotine replacement therapy
Bupropion
Nortriptyline
Varenicline

29

Breast Cancer Group

To assess the effects of conservative (non-surgical and non-pharmacological) interventions for preventing clinically-detectable upper-limb lymphoedema after breast cancer treatment. New Review 2015/02 10.1002/14651858.CD009765.pub2 Lymphedema
Breast cancer management

30

Stroke Group

To determine: (1) whether interventions improve community ambulation for stroke survivors, and (2) if any specific intervention method improves community ambulation more than other interventions. New Review 2015/03 10.1002/14651858.CD010200.pub2 Stroke

31

Incontinence Group

To evaluate the efficacy of transurethral radiofrequency collagen denaturation, compared with other interventions, in the treatment of women with UI. New Review 2015/03 10.1002/14651858.CD010217.pub2 Urinary incontinence
Collagen

32

Acute Respiratory Infections Group

To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media (AOM) in infants and children. New Review 2015/03 10.1002/14651858.CD010089.pub2 Influenza vaccine
Otitis media

33

Developmental, Psychosocial and Learning Problems Group

To assess the efficacy of non-speech oral motor treatment (NSOMT) in treating children with developmental speech sound disorders who have speech errors. New Review 2015/03 10.1002/14651858.CD009383.pub2 Speech disorder

34

Oral Health Group

To assess the effects of different xylitol-containing products for the prevention of dental caries in children and adults. New Review 2015/03 10.1002/14651858.CD010743.pub2 Dental caries
Xylitol

35

Menstrual Disorders and Subfertility Group

To assess the short-term (within 12 months) effectiveness and safety of add-back therapy for women using GnRH analogues for uterine fibroids associated with excessive uterine bleeding, pelvic pain, or urinary symptoms. New Review 2015/03 10.1002/14651858.CD010854.pub2 Uterine fibroid
Gonadotropin-releasing hormone
Hot flash

36

Fertility Regulation Group

To determine the effects of hormonal contraceptives on lactation and infant growth Unchanged 2015/03 10.1002/14651858.CD003988.pub2 Hormonal contraception
Lactation

37

Menstrual Disorders and Subfertility Group

To assess the effectiveness and safety of endometrial injury performed before embryo transfer in women undergoing assisted reproductive techniques (ART). Changed 2015/03 10.1002/14651858.CD009517.pub3 Assisted reproductive technology

38

Cystic Fibrosis and Genetic Disorders Group

To evaluate the effects of CFTR potentiators on clinically important outcomes in children and adults with cystic fibrosis. New Review 2015/03 10.1002/14651858.CD009841.pub2 Cystic fibrosis

39

Drugs and Alcohol Group

To assess the efficacy and safety of baclofen for people with alcohol withdrawal syndrome (AWS). Unchanged 2015/04 10.1002/14651858.CD008502.pub4 Alcohol withdrawal syndrome
Baclofen

40

Epilepsy Group

To determine: (1) The effects on seizures of vagus nerve stimulation (VNS) compared to controls e.g. high-level stimulation compared to low-level stimulation (presumed sub-therapeutic dose); and (2) The adverse effect profile of VNS compared to controls e.g. high-level stimulation compared to low-level stimulation. Unchanged 2015/04 10.1002/14651858.CD002896.pub2 Vagus nerve stimulation
Epilepsy

41

Pregnancy and Childbirth Group

The objective of this review was to assess the effects of external cephalic version (ECV) at or near term on measures of pregnancy outcome. Methods of facilitating ECV, and ECV before term are reviewed separately. Unchanged 2015/04 10.1002/14651858.CD000083.pub3 External cephalic version

42

Pain, Palliative and Supportive Care Group

To assess the effectiveness and tolerability of buprenorphine for pain in adults and children with cancer. Unchanged 2015/03 10.1002/14651858.CD009596.pub4 Buprenorphine
Cancer pain

43

Effective Practice and Organisation of Care Group

To assess the evidence on the effectiveness of available strategies that focus on delivery and appropriate use of insecticide-treated bednets (ITNs). New Review 2015/03 10.1002/14651858.CD009186.pub2 Mosquito net
Global health

44

Anaesthesia Group

To assess the effect of melatonin on pre- and postoperative anxiety in adults when comparing melatonin with placebo or when comparing melatonin with benzodiazepines. New Review 2015/04 10.1002/14651858.CD009861.pub2 Preoperational_anxiety checkY

45

Depression, Anxiety and Neurosis Group

To assess the effects of debriefing interventions compared with standard postnatal care for the prevention of psychological trauma in women following childbirth. Unchanged 2015/04 10.1002/14651858.CD007194.pub2 Childbirth

46

Anaesthesia Group

To estimate the effectiveness of preoperative or intraoperative warming, or both, of intravenous and irrigation fluids in preventing perioperative hypothermia and its complications during surgery in adults. New Review 2015/04 10.1002/14651858.CD009891.pub2 Hypothermia
Surgery

47

Pain, Palliative and Supportive Care Group

To assess the clinical efficacy and safety of feverfew monopreparations versus placebo for preventing migraine. Unchanged 2015/04 10.1002/14651858.CD002286.pub3 Tanacetum parthenium
Migraine

48

Bone, Joint and Muscle Trauma Group

To assess the effects (benefits and harms) of red blood cell transfusion in people undergoing surgery for hip fracture. New 2015/04 10.1002/14651858.CD009699.pub2 Hip fracture checkY

49

Multiple Sclerosis and Rare Diseases of the Central Nervous System Group

To assess the benefit and safety of dimethyl fumarate as monotherapy or combination therapy versus placebo or other approved disease-modifying drugs (interferon beta, glatiramer acetate, natalizumab, mitoxantrone, fingolimod, teriflunomide, alemtuzumab) for patients with MS. New 2015/04 10.1002/14651858.CD011076.pub2 Multiple sclerosis

50

Pain, Palliative and Supportive Care Group

To evaluate the efficacy of corticosteroids in treating cancer-related pain in adults. New 2015/04 10.1002/14651858.CD010756.pub2 Corticosteroid
Cancer pain

51

Renal Group

To determine the diagnostic accuracy of state (one time), minimally invasive clinical symptoms, signs and tests to be used as screening tests for detecting water-loss dehydration in older people by systematically reviewing studies that have measured a reference standard and at least one index test in people aged 65 years and over. Water-loss dehydration was defined primarily as including everyone with either impending or current water-loss dehydration (including all those with serum osmolality ≥ 295 mOsm/kg as being dehydrated). New 2015/04 10.1002/14651858.CD009647.pub2 Dehydration

52

Musculoskeletal Group

To synthesise the available evidence regarding the benefits and harms of vertebroplasty for treatment of osteoporotic vertebral fractures. New 2015/04 10.1002/14651858.CD006349.pub2 Percutaneous vertebroplasty checkY

53

Heart Group

To assess the potential benefits of influenza vaccination for primary and secondary prevention of cardiovascular disease. Changed 2015/05 10.1002/14651858.CD005050.pub3 Cardiovascular disease
Influenza vaccine

54

Neuromuscular Disease Group

To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell’s palsy. Unchanged 2015/05 10.1002/14651858.CD001869.pub5 Bell's palsy

55

Pain, Palliative and Supportive Care Group

To determine the efficacy and tolerability of selective serotonin re-uptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) compared to placebo and other active interventions in the prevention of episodic and chronic tension-type headache in adults. Unchanged 2015/05 10.1002/14651858.CD011681 Tension headache
Selective serotonin reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitor

56

Inflammatory Bowel Disease and Functional Bowel Disorders Group

The objectives of this review were to assess the efficacy and safety of anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease. New 2015/05 10.1002/14651858.CD007572.pub2 Crohn's disease

57

Skin Group

To assess the effects of interventions (except laser and light-based therapies alone) for hirsutism. New 2015/04 10.1002/14651858.CD010334.pub2 Hirsutism

58

Skin Group

To assess the efficacy and safety of treatments for rosacea. Changed 2015/04 10.1002/14651858.CD003262.pub5 Rosacea

59

Musculoskeletal Group

To assess the benefit and harms of adalimumab, etanercept, golimumab, and infliximab (TNF-alpha inhibitors) in people with ankylosing spondylitis. New 2015/04 10.1002/14651858.CD005468.pub2 Ankylosing spondylitis

Adalimumab
Etanercept
Golimumab
Infliximab

checkY

60

Drugs and Alcohol Group

To evaluate the effectiveness of psychosocial interventions for treating benzodiazepines (BZD) harmful use, abuse or dependence compared to pharmacological interventions, no intervention, placebo or a different psychosocial intervention on reducing the use of BZDs in opiate dependent and non-opiate dependent groups. New 2015/05 10.1002/14651858.CD009652.pub2 Benzodiazepine

61

Injuries Group

To assess the effects of using fresher versus older red blood cells in people requiring a red blood cell transfusion. New 2015/05 10.1002/14651858.CD010801.pub2 Blood transfusion

62

Pain, Palliative and Supportive Care Group

To determine the effectiveness and differential efficacy of laxatives used to manage constipation in people receiving palliative care. Changed 2015/05 10.1002/14651858.CD003448.pub4 Laxative
Palliative care

63

Bone, Joint and Muscle Trauma Group

To evaluate the effects (benefits and harms) of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle. Changed 2015/05 10.1002/14651858.CD007428.pub3 Clavicle fracture checkY

64

Menstrual Disorders and Subfertility Group

To evaluate the effect of flushing fallopian tubes with oil- or water-soluble contrast media on live birth and pregnancy rates in women with subfertility. Unchanged 2015/05 10.1002/14651858.CD003718.pub4 Infertility
Fallopian tube

65

Cystic Fibrosis and Genetic Disorders Group

To examine the evidence that psychological interventions improve the ability of people with sickle cell disease to cope with their condition. Unchanged 2015/05 10.1002/14651858.CD001916.pub3 Sickle-cell disease

66

Tobacco Addiction Group

To determine whether incentives and contingency management programmes lead to higher long-term quit rates. Changed 2015/05 10.1002/14651858.CD004307.pub5 Smoking cessation

67

Gynaecological Cancer Group

To determine the benefits and risks of PARP inhibitors for the treatment of epithelial ovarian cancer (EOC). Changed 2015/05 10.1002/14651858.CD007929.pub3 Ovarian cancer

68

Upper Gastrointestinal and Pancreatic Diseases Group

The objective of this review is to determine the role of preoperative chemotherapy in the treatment of patients with resectable thoracic esophageal carcinoma. Unchanged 2015/05 10.1002/14651858.CD001556.pub3 Esophageal cancer

69

Heart Group

To systematically assess the efficacy and safety of Tong-xin-luo capsules in preventing cardiovascular events after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). New 2015/05 10.1002/14651858.CD010237.pub2 Coronary artery disease
Percutaneous coronary intervention

70

Wound Group

To assess the effects of negative pressure wound therapy for treating pressure ulcers in any care setting. New 2015/05 10.1002/14651858.CD011334.pub2 Pressure ulcer
Negative-pressure wound therapy

71

Pregnancy and Childbirth Group

To assess the effects of education during pregnancy to increase energy and protein intake, or of actual energy and protein supplementation, on energy and protein intake, and the effect on maternal and infant health outcomes. Changed 2015/06 10.1002/14651858.CD000032.pub3 Pregnancy

72

Colorectal Cancer Group

To compare water infusion techniques with standard air insufflation, specifically evaluating technical quality and screening efficacy, as well as patients’ acceptance of the water infusion procedure. New 2015/05 10.1002/14651858.CD009863.pub2 Colorectal cancer

73

Breast Cancer Group

To assess the effects of psychological interventions on psychological morbidities, quality of life and survival among women with non-metastatic breast cancer. New 2015/05 10.1002/14651858.CD008729.pub2 Breast cancer

74

Skin Group

To assess the effects and safety of sentinel lymph node biopsy (SLNB) followed by completion lymph node dissection (CLND) for the treatment of localised primary cutaneous melanoma. New 2015/05 10.1002/14651858.CD010307.pub2 Melanoma

75

Inflammatory Bowel Disease and Functional Bowel Disorders Group

The primary objective was to evaluate the efficacy and safety of oral budesonide for the induction of remission in Crohn's disease. Changed 2015/06 10.1002/14651858.CD000296.pub4 Crohn's disease
Budesonide

76

Eyes and Vision Group

The objective of this review was to assess the effects of topical antihistamines and mast cell stabilisers, alone or in combination, for use in treating seasonal and perennial allergic conjunctivitis. New 2015/06 10.1002/14651858.CD009566.pub2 Allergic conjunctivitis

77

Pregnancy and Childbirth Group

To assess the impact of Hib and viral Influenza vaccinations during pregnancy on maternal, neonatal and infant health outcomes compared to placebo/control. New 2015/06 10.1002/14651858.CD009982.pub2

78

Breast Cancer Group

The objective of this review was to compare taxane-containing chemotherapy regimens with regimens not containing a taxane in the management of women with metastatic breast cancer. Unchanged 2015/06 10.1002/14651858.CD003366.pub3 Metastatic breast cancer
Chemotherapy
Taxane

79

Heart Group

To assess the effect of reducing saturated fat intake and replacing it with carbohydrate (CHO), polyunsaturated (PUFA) or monounsaturated fat (MUFA) and/or protein on mortality and cardiovascular morbidity, using all available randomised clinical trials. New 2015/06 10.1002/14651858.CD011737 Cardiovascular disease
Saturated fat

80

Pregnancy and Childbirth Group

To evaluate the effectiveness of diet or exercise, or both, interventions for preventing excessive weight gain during pregnancy and associated pregnancy complications. Changed 2015/06 10.1002/14651858.CD007145.pub3 Pregnancy

81

Musculoskeletal Group

The objective was to assess the benefits and harms of selective serotonin reuptake inhibitors (SSRIs) in the treatment of fibromyalgia. New 2015/06 10.1002/14651858.CD011735 Selective serotonin reuptake inhibitor
Fibromyalgia
Added to talk page; 2009 JAMA meta-analysis referenced in fibromyalgia article has different results to Cochrane SR.

82

Acute Respiratory Infections Group

To evaluate the effectiveness of exercise for altering the occurrence, severity or duration of acute respiratory infections. New 2015/06 10.1002/14651858.CD010596.pub2 Influenza-like illness

83

Epilepsy Group

To evaluate the efficacy and tolerability of lacosamide when used as an add-on treatment for patients with drug-resistant partial epilepsy. New 2015/06 10.1002/14651858.CD008841.pub2 Epilepsy
Lacosamide

84

Cystic Fibrosis and Genetic Disorders Group

To determine the effectiveness and acceptability of positive expiratory pressure (PEP) devices compared to other forms of physiotherapy as a means of improving mucus clearance and other outcomes in people with cystic fibrosis. Changed 2015/06 10.1002/14651858.CD003147.pub4 Cystic fibrosis

85

Oral Health Group

To evaluate the effects of water fluoridation (artificial or natural) on the prevention of dental caries.

To evaluate the effects of water fluoridation (artificial or natural) on dental fluorosis.

New 2015/06 10.1002/14651858.CD010856.pub2 Water fluoridation
Dental caries
Dental fluorosis

86

Acute Respiratory Infections Group

To assess the effects of antibiotics for children with acute otitis media (AOM). Unchanged 2015/06 10.1002/14651858.CD000219.pub4 Otitis media

87

Dementia and Cognitive Improvement Group

To determine the diagnostic accuracy of regional cerebral blood flow (rCBF) single-photon emission computed tomography (SPECT) for diagnosing frontotemporal dementia (FTD) in populations with suspected dementia in secondary/tertiary healthcare settings and in the differential diagnosis of FTD from other dementia subtypes. New 2015/06 10.1002/14651858.CD010896.pub2 Frontotemporal dementia
Single-photon emission computed tomography

88

Gynaecological Cancer Group

To assess the effects of early postoperative radiotherapy versus radiotherapy delayed until tumour progression for low-grade intracranial gliomas in people who had initial biopsy or surgical resection. New 2015/06 10.1002/14651858.CD009229.pub2 Glioma

89

Vascular Group

To assess the effectiveness of oral direct thrombin inhibitors (DTIs) and oral factor Xa inhibitors for the treatment of deep vein thrombosis (DVT). New 2015/06 10.1002/14651858.CD010956.pub2 Deep vein thrombosis
Direct Xa inhibitor
Direct thrombin inhibitor
Anticoagulant

90

Incontinence Group

To assess the clinical effects of mid-urethral sling (MUS) operations for the treatment of stress urinary incontinence (SUI), urodynamic stress incontinence (USI) or mixed urinary incontinence (MUI) in women. Unchanged 2015/07 10.1002/14651858.CD006375.pub3 Stress incontinence
Urinary incontinence

91

Neuromuscular Disease Group

To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell’s palsy. Changed 2015/07 10.1002/14651858.CD001869.pub6 Bell's palsy

92

Skin Group

To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments. Unchanged 2015/07 10.1002/14651858.CD009864.pub2 Atopic dermatitis
Tacrolimus

93

Back Group

To determine the effects of the Pilates method for patients with non-specific acute, subacute or chronic low back pain. New 2015/07 10.1002/14651858.CD010265.pub2 Pilates
Low back pain

94

Pregnancy and Childbirth Group

To assess the effectiveness and safety of repeat dose(s) of prenatal corticosteroids. Unchanged 2015/07 10.1002/14651858.CD003935.pub4 Corticosteroid

95

Depression, Anxiety and Neurosis Group

To identify all randomised controlled trials of pharmacological agents or natural products for self harm in adults, and to conduct meta-analyses (where possible) to compare the effects of specific treatments with comparison types of treatment (e.g., placebo/alternative pharmacological treatment) for self harming patients. New 2015/07 10.1002/14651858.CD011777 Self-harm

96

Anaesthesia, Critical & Emergency Care Group

We assessed the benefits and harms of prothrombin complex concentrate (PCC) compared with fresh frozen plasma in the acute medical and surgical setting involving vitamin K antagonist-treated bleeding and non-bleeding patients. New 2015/07 10.1002/14651858.CD010555.pub2 Prothrombin complex concentrate

97

Vascular Group

To compare the efficacy and safety of the ambulatory conservative hemodynamic correction of venous insufficiency method (cure conservatrice et hémodynamique de l'insuffisance veineuse en ambulatoire (CHIVA)) with alternative therapeutic techniques to treat varicose veins. Unchanged 2015/06 10.1002/14651858.CD009648.pub3 Varicose veins

98

Pain, Palliative & Supportive Care Group

To assess the analgesic efficacy and adverse effects of a single oral dose of diclofenac for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes. Changed 2015/07 10.1002/14651858.CD004768.pub3 Diclofenac

99

Fertility Regulation Group

Our aim was to examine the outcomes of intrauterine contraception (IUC) insertion immediately after placenta delivery (within 10 minutes), especially when compared with insertion at other postpartum times. We focused on successful IUC placement (insertion), subsequent expulsion, and method use. Changed 2015/06 10.1002/14651858.CD003036.pub3 Intrauterine device

100

Renal Group

The aim of this review was to assess benefits and harms of different nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids in the treatment of adult patients with acute renal colic and if possible to determine which medication (or class of medications) are more appropriate for this purpose. Clinically relevant outcomes such as efficacy of pain relief, time to pain relief, recurrence of pain, need for rescue medication and side effects were explored. New 2015/07 10.1002/14651858.CD006027.pub2 Nonsteroidal anti-inflammatory drug
Renal colic

101

Heart Group

This review aimed to examine the efficacy of psychosocial interventions for smoking cessation in patients with coronary heart disease in short-term (6 to 12 month follow-up) and long-term (more than 12 months). Moderators of treatment effects (i.e. intervention types, treatment dose, methodological criteria) were used for stratification. Unchanged 2015/07 10.1002/14651858.CD006886.pub2 Coronary artery disease

102

Pregnancy and Childbirth Group

To assess the effects of daily oral iron supplements for pregnant women, either alone or in conjunction with folic acid, or with other vitamins and minerals as a public health intervention in antenatal care. Unchanged 2015/07 10.1002/14651858.CD004736.pub5

103

Pregnancy and Childbirth Group

To assess the effect of n-3 LCPUFA supplementation in pregnant and/or breastfeeding women on allergy outcomes (food allergy, atopic dermatitis (eczema), allergic rhinitis (hay fever) and asthma/wheeze) in their children. New 2015/07 10.1002/14651858.CD010085.pub2

104

Methodology Review Group

To assess the impact that smartphone and tablet apps as a delivery mode have on the quality of survey questionnaire responses compared to any other alternative delivery mode: paper, laptop computer, tablet computer (manufactured before 2007), short message service (SMS) and plastic objects. New 2015/07 10.1002/14651858.MR000042.pub2

105

Pregnancy and Childbirth Group

To assess the effectiveness of a policy of beginning external cephalic version (ECV) before term (before 37 weeks' gestation) for breech presentation on fetal presentation at birth, method of delivery, and the rate of preterm birth, perinatal morbidity, stillbirth or neonatal mortality. New 2015/07 10.1002/14651858.CD000084.pub3

106

Lung Cancer Group

To determine the effectiveness of platinum chemotherapy regimens compared with non-platinum chemotherapy regimens in the treatment of small cell lung cancer with respect to survival, tumour response, toxicity and quality of life. Unchanged 2015/08 10.1002/14651858.CD006849.pub3 Small-cell carcinoma
Chemotherapy

107

Skin Group

To assess the effects of interventions for the prevention of herpes simplex labialis (cold sores on the lips) in people of all ages. New 2015/08 10.1002/14651858.CD010095.pub2 Herpes labialis
Herpes simplex virus

108

Heart Group

To assess the effects of proportion of energy intake from fat on measures of weight and body fatness (including obesity, waist circumference and body mass index) in people not aiming to lose weight, using all appropriate randomised controlled trials (RCTs) and cohort studies in adults, children and young people New 2015/08 10.1002/14651858.CD011834

109

Anaesthesia, Critical and Emergency Care Group

To assess the effects of regional anaesthesia and analgesia on long-term functional outcomes 3, 6 and 12 months after elective major joint (knee, shoulder and hip) replacement surgery. New 2015/08 10.1002/14651858.CD010278.pub2 Joint replacement

110

Epilepsy Group

To compare the efficacy of antiepileptic drugs and neuroprotective agents with placebo, usual care or other pharmacologic agents for the prevention of post-traumatic epilepsy in people diagnosed with any severity of traumatic brain injury. New 2015/08 10.1002/14651858.CD009900.pub2 Post-traumatic epilepsy

111

Bone, Joint and Muscle Trauma Group

To assess the effects (benefits and harms) of interventions for treating fractures of the distal femur in adults. New 2015/08 10.1002/14651858.CD010606.pub2 Femoral fracture checkY

112

Heart Group

To determine the effectiveness of preoperative statin therapy in patients undergoing cardiac surgery. Changed 2015/08 10.1002/14651858.CD008493.pub3

113

Eyes and Vision Group

This updated review aimed to summarise the effects of anti-VEGF use to reduce the occurrence of POVCH after vitrectomy surgery for PDR. Changed 2015/08 10.1002/14651858.CD008214.pub3

114

Pregnancy and Childbirth Group

To assess the effectiveness and safety of different interventions for treating leg cramps in pregnancy. New 2015/08 10.1002/14651858.CD010655.pub2 checkY

115

Skin Group

To assess the effects and safety of oral fumaric acid esters for psoriasis. New 2015/08 10.1002/14651858.CD010497.pub2 Psoriasis

116

Menstrual Disorders and Subfertility Group

To assess the effectiveness and safety of different surgical approaches to hysterectomy for women with benign gynaecological conditions. Changed 2015/08 10.1002/14651858.CD003677.pub5 Hysterectomy

117

Schizophrenia Group

To determine whether voxel-based morphometry applied to the brain can be used to differentiate schizophrenia from other types of psychosis in participants who have received a clinical diagnosis of first episode psychosis. New 2015/08 10.1002/14651858.CD011021.pub2 Voxel-based morphometry
Psychosis

118

Pregnancy and Childbirth Group

To assess the effects of different treatments for the management of breast abscesses in breastfeeding women. New 2015/08 10.1002/14651858.CD010490.pub2

119

Heart Group

To compare the effect of home-based and supervised centre-based cardiac rehabilitation on mortality and morbidity, health-related quality of life, and modifiable cardiac risk factors in patients with heart disease. Unchanged 2015/08 10.1002/14651858.CD007130.pub3

120

Childhood Cancer Group

To determine the effects of any form of parenteral (PN) or enteral (EN) nutritional support, excluding vitamin supplementation and micronutrient supplementation, in children and young people with cancer undergoing chemotherapy and to determine the effect of the nutritional content of PN and EN. This is an update of a previous Cochrane review. Changed 2015/08 10.1002/14651858.CD003298.pub3

121

Hypertension Group

To quantify the dose-related effects of various types of dual alpha and beta adrenergic receptor blockers (dual receptor blockers) on systolic and diastolic blood pressure versus placebo in patients with primary hypertension. New 2015/08 10.1002/14651858.CD007449

122

Airways Group

To assess the efficacy and safety of sublingual immunotherapy compared with placebo or standard care for adults and children with asthma. New 2015/08 10.1002/14651858.CD011293.pub2

123

Stroke Group

To assess whether different parenteral fluid regimens lead to differences in death, or death or dependence, after stroke based on fluid type, fluid volume, duration of fluid administration, and mode of delivery. New 2015/09 10.1002/14651858.CD011138.pub2

124

Pregnancy and Childbirth Group

To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies. Unchanged 2015/09 10.1002/14651858.CD000020.pub3

125

Wounds Group

To determine the effects and safety of systemic antibiotics in the treatment of DFIs compared with other systemic antibiotics, topical foot care or placebo. New 2015/09 10.1002/14651858.CD009061.pub2 Diabetic foot checkY

126

Stroke Group

To: 1) compare the safety and efficacy of transcatheter device closure with best medical therapy alone for preventing recurrent stroke (fatal or non-fatal) or transient ischemic attacks (TIAs) in people with PFO and a history of cryptogenic stroke or TIA; 2) identify specific subgroups of people most likely to benefit from closure for secondary prevention; and 3) assess the cost-effectiveness of this strategy, if possible. New 2015/09 10.1002/14651858.CD009938.pub2

127

Stroke Group

To: 1) compare the safety and efficacy of transcatheter device closure with best medical therapy alone for preventing recurrent stroke (fatal or non-fatal) or transient ischemic attacks (TIAs) in people with PFO and a history of cryptogenic stroke or TIA; 2) identify specific subgroups of people most likely to benefit from closure for secondary prevention; and 3) assess the cost-effectiveness of this strategy, if possible. New 2015/09 10.1002/14651858.CD009938.pub2

128

Menstrual Disorders and Subfertility Group

To evaluate the benefits and risks of different laparoscopic entry techniques in gynaecological and non-gynaecological surgery. Unchanged 2015/08 10.1002/14651858.CD006583.pub4

129

Pregnancy and Childbirth Group

To assess the effectiveness and safety of all interventions for nausea, vomiting and retching in early pregnancy, up to 20 weeks’ gestation. Unchanged 2015/09 10.1002/14651858.CD007575.pub4

130

Multiple Sclerosis and Rare Diseases of the Central Nervous System Group

To determine the effectiveness and safety of exercise therapy compared to a no-exercise control condition or another intervention on fatigue, measured with self-reported questionnaires, of people with MS. New 2015/09 10.1002/14651858.CD009956.pub2

131

Vascular Group

To determine the effectiveness (improvement or deterioration in symptoms) and safety of rutosides for treatment of post-thrombotic syndrome (PTS) in patients with DVT compared to placebo, no intervention, elastic compression stockings (ECS) or any other treatment. Unchanged 2015/09 10.1002/14651858.CD005625.pub3

132

Bone, Joint and Muscle Trauma Group

To assess the effects (benefits and harms) of whole-body cryotherapy (extreme cold air exposure) for preventing and treating muscle soreness after exercise in adults. New 2015/09 10.1002/14651858.CD010789.pub2 Cryotherapy checkY

133

Eyes and Vision Group

To assess the relative effectiveness and safety of combined surgery versus cataract surgery (phacoemulsification) alone for co-existing cataract and glaucoma. The secondary objectives include cost analyses for different surgical techniques for co-existing cataract and glaucoma. New 2015/07 10.1002/14651858.CD008671.pub3

134

Wounds Group

To summarize data from systematic reviews of randomised controlled trial evidence on the effectiveness of dressings for healing foot ulcers in people with diabetes mellitus (DM). New 2015/07 10.1002/14651858.CD010471.pub2 Diabetic foot ulcer checkY

135

Pain, Palliative and Supportive Care Group

To assess the effectiveness and safety of drugs for treating PDPH in adults and children. Stable 2015/07 10.1002/14651858.CD007887.pub3

136

Pain, Palliative and Supportive Care Group

To assess the analgesic efficacy and adverse effects of a single oral dose of ibuprofen plus caffeine for moderate to severe postoperative pain, using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes. New 2015/07 10.1002/14651858.CD011509.pub2

137

Metabolic and Endocrine Disorders Group

To assess the effects of aromatase inhibitors in male children and adolescents with short stature. New 2015/10 10.1002/14651858.CD010888.pub2

138

Movement Disorders Group

To evaluate the effects of pharmacological and non-pharmacological interventions, compared to an inactive control intervention, on subjective fatigue in people with PD. New 2015/10 10.1002/14651858.CD010925.pub2

139

Skin Group

To assess the effects of interventions for HS in people of all ages. New 2015/10 10.1002/14651858.CD010081.pub2

140

Gynaecological Cancer Group

To assess the effect of cervical treatment for cervical intra-epithelial neoplasia (CIN, excisional or ablative) on fertility and early pregnancy outcomes. New 2015/09 10.1002/14651858.CD008478.pub2 Cervical intraepithelial neoplasia

141

Pain, Palliative and Supportive Care Group

To summarise the efficacy of pharmaceutical interventions for acute pain in adults with at least moderate pain following surgery who have been given a single dose of oral analgesic. Stable 2015/09 10.1002/14651858.CD008659.pub3

142

Pain, Palliative and Supportive Care Group

To provide an overview of adverse event rates associated with single-dose oral analgesics, compared with placebo, for acute postoperative pain in adults. New 2015/10 10.1002/14651858.CD011407.pub2

143

ENT Group

To assess the benefits and harms of tonsillectomy with or without adenoidectomy compared with non-surgical management of children with obstructive sleep-disordered breathing. New 2015/10 10.1002/14651858.CD011165.pub2 Tonsillectomy
Adenoidectomy

144

Musculoskeletal Group

To assess the benefits and harms of any conservative treatment for ankle osteoarthritis in adults in order to provide a synthesis of the evidence as a base for future treatment guidelines. New 2015/10 10.1002/14651858.CD010643.pub2 Osteoarthritis checkY

145

Pregnancy and Childbirth Group

To assess the effects of prenatal education for preventing congenital toxoplasmosis. Unchanged 2015/10 10.1002/14651858.CD006171.pub4 Toxoplasmosis
Prenatal care

146

Eyes and Vision Group

To examine the effectiveness and adverse effects of laser photocoagulation of drusen in age-related macular degeneration. Changed 2015/10 10.1002/14651858.CD006537.pub3 Macular degeneration
Drusen
Laser coagulation

147

Pregnancy and Childbirth Group

To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements on pregnancy outcomes, adverse events, side effects and use of health resources. Changed 2015/09 10.1002/14651858.CD004072.pub3 Vitamin C
Pregnancy

148

Pregnancy and Childbirth Group

To assess outcomes of pregnancy where fetal movement counting was done routinely, selectively or was not done at all; and to compare different methods of fetal movement counting. Unchanged 2015/10 10.1002/14651858.CD004909.pub3 Fetal movement

149

Developmental, Psychosocial and Learning Problems Group

To determine whether commercially-available sleep positioning systems, compared with usual care, reduce or prevent hip migration in children with cerebral palsy. Any negative effect of sleep positioning systems on hip migration will be considered within this objective.

Secondary objectives were to determine the effect of sleep positioning systems on: (1) number or frequency of hip problems; (2) sleep patterns and quality; (3) quality of life of the child and family; (4) pain; and (5) physical functioning. We also sought to identify any adverse effects from using sleep positioning systems.

New 2015/11 10.1002/14651858.CD009257.pub2 Cerebral palsy
Sleeping positions

150

Pregnancy and Childbirth Group

To evaluate the benefits of oral multiple-micronutrient supplementation during pregnancy on maternal, fetal and infant health outcomes. Changed 2015/11 10.1002/14651858.CD004905.pub4 Pregnancy

151

Developmental, Psychosocial and Learning Problems Group

To assess the effectiveness of anti-dementia pharmacological interventions and nutritional supplements for treating cognitive decline in people with Down syndrome. New 2015/10 10.1002/14651858.CD011546.pub2 Down syndrome

152

Bone, Joint and Muscle Trauma Group

To assess the effects (benefits and harms) of treatment and rehabilitation interventions for proximal humeral fractures in adults. Changed 2015/11 10.1002/14651858.CD000434.pub4 Humerus fracture checkY

153

Gynaecological, Neuro-oncology and Orphan Cancer Group

To evaluate the effectiveness and tolerability of cannabis-based medications for chemotherapy-induced nausea and vomiting in adults with cancer. New 2015/11 10.1002/14651858.CD009464.pub2

154

Heart Group

The two primary objectives of this Cochrane review were to determine the effectiveness of:

1. Increasing omega 6 (Linoleic acid (LA), Gamma-linolenic acid (GLA), Dihomo-gamma-linolenic acid (DGLA), Arachidonic acid (AA), or any combination) intake in place of saturated or monounsaturated fats or carbohydrates for the primary prevention of cardiovascular disease. 2. Decreasing omega 6 (LA, GLA, DGLA, AA, or any combination) intake in place of carbohydrates or protein (or both) for the primary prevention of cardiovascular disease.

New 2015/11 10.1002/14651858.CD011094.pub2

155

Eyes and Vision Group

To assess the effects of interventions for trachomatous trichiasis for people living in endemic settings. Changed 2015/11 10.1002/14651858.CD004008.pub3

156

Anaesthesia, Critical and Emergency Care Group

The objectives of this review are (1) to ascertain whether prone ventilation offers a mortality advantage when compared with traditional supine or semirecumbent ventilation in patients with severe acute respiratory failure requiring conventional invasive artificial ventilation, and (2) to supplement previous systematic reviews on prone ventilation for hypoxaemic respiratory failure in an adult population. New 2015/11 10.1002/14651858.CD008095.pub2

157

Anaesthesia, Critical and Emergency Care Group

To identify and evaluate all randomized controlled trials (RCTs) involving participants undergoing elective or emergency airway management via rapid sequence induction and compare participants who have cricoid pressure administered with participants who do not have cricoid pressure administered. New 2015/11 10.1002/14651858.CD011656.pub2 Cricoid pressure

158

Airways Group

To assess the safety and efficacy of adding a long-acting beta2-agonists (LABA) to an inhaled corticosteroids (ICS) in children and adolescents with asthma. To determine whether the benefit of LABA was influenced by baseline severity of airway obstruction, the dose of ICS to which it was added or with which it was compared, the type of LABA used, the number of devices used to deliver combination therapy and trial duration. Unchanged 2015/11 10.1002/14651858.CD007949.pub2

159

Oral Health Group

To assess the effect of non-surgical adjunctive interventions on the rate of orthodontic tooth movement and the overall duration of treatment. New 2015/11 10.1002/14651858.CD010887.pub2

160

Metabolic and Endocrine Disorders Group

To assess the optimal surgical technique for Graves' disease and Graves' ophthalmopathy. New 2015/11 10.1002/14651858.CD010576.pub2

161

Developmental, Psychosocial and Learning Problems Group

To assess the beneficial and harmful effects of methylphenidate for children and adolescents with ADHD. New 2015/11 10.1002/14651858.CD009885.pub2

162

Acute Respiratory Infections Group

To assess the effects of antihistamines on the common cold. New 2015/11 10.1002/14651858.CD009345.pub2

163

Eyes and Vision Group

To assess the relative effectiveness, primarily with respect to intraocular pressure (IOP) control and safety, of the use of different devices as adjuncts to trabeculectomy compared with standard trabeculectomy in eyes with glaucoma. New 2015/12 10.1002/14651858.CD010472.pub2

164

Kidney and Transplant

This review of randomised controlled trials (RCTs) aimed to look at the benefits and harms of mycophenolic acid versus azathioprine in primary immunosuppressive regimens after kidney transplantation. Both agents were compared regarding their efficacy for maintaining graft and patient survival, prevention of acute rejection, maintaining graft function, and their safety, including infections, malignancies and other adverse events. Furthermore, we investigated potential effect modifiers, such as transplantation era and the concomitant immunosuppressive regimen in detail. New 2015/12 10.1002/14651858.CD007746.pub2

165

Upper GI and Pancreatic Diseases

To assess the effects of periodontal therapy plus eradication therapy versus eradication therapy alone for gastric H. pylori infection.. New 2016/02 10.1002/14651858.CD009477.pub2 Helicobacter pylori

Helicobacter pylori eradication protocols

checkY

166

Common Mental Disorders

to determine the effects of exercise therapy (ET) for patients with CFS as compared with any other intervention or control. Unchanged 2016/02 10.1002/14651858.CD003200.pub4 Chronic fatigue syndrome treatment

Chronic fatigue syndrome

checkY

167

Epilepsy

To review the evidence for efficacy and tolerability from randomised controlled trials regarding the effects of ketogenic diet and similar diets for epilepsy. No change to conclusions 2016/02 10.1002/14651858.CD001903.pub3 Epilepsy
Ketogenic diet

168

Back and Neck

To evaluate the effectiveness of motor control exercises for patients with acute non-specific low back pain. New 2016/02 10.1002/14651858.CD012085 Low back pain
Exercise therapy
Related reviews: Saragiotto BT, Maher CG, Yamato TP, Costa LOP, Menezes Costa LC, Ostelo RWJG, Macedo LG. Motor control exercise for chronic non-specific low-back pain. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD012004. DOI: 10.1002/14651858.CD012004

Yamato TP, Maher CG, Saragiotto BT, Hancock MJ, Ostelo RWJG, Cabral CMN, Menezes Costa LC, Costa LOP. Pilates for low back pain. Cochrane Database of Systematic Reviews 2015, Issue 7. Art. No.: CD010265. DOI: 10.1002/14651858.CD010265.pub2. (Evidently Cochrane blog: http://www.evidentlycochrane.net/pilates-new-evidence-on-help-for-low-back-pain/ and blogshot in July 2015)

169

Drugs and Alcohol

To assess the effectiveness of interventions involving the use of alpha2-adrenergic agonists compared with placebo, reducing doses of methadone, symptomatic medications, or an alpha2-adrenergic agonist regimen different to the experimental intervention, for the management of the acute phase of opioid withdrawal. Outcomes included the withdrawal syndrome experienced, duration of treatment, occurrence of adverse effects, and completion of treatment. Unchanged 2016/05 10.1002/14651858.CD002024.pub5 Opioid use disorder
Opioid

170

Pain, Palliative and Supportive Care

To ascertain the optimal management strategy for adults with malignant pleural effusion in terms of pleurodesis success. Additionally, to quantify differences in patient-reported outcomes and adverse effects between management strategies. New 2016/05 10.1002/14651858.CD010529.pub2 Malignant pleural effusion

171

Drugs and Alcohol Care

To assess the effects of maintenance agonist pharmacotherapy for the treatment of pharmaceutical opioid dependence. New 2016/05 10.1002/14651858.CD011117.pub2 Opioid use disorder
Opioid

172

Tobacco Addiction

To review the efficacy of nicotine receptor partial agonists, including varenicline and cytisine, for smoking cessation. Changed 2016/05 10.1002/14651858.CD006103.pub7 Smoking cessation

173

Pregnancy and Childbirth

To assess the effectiveness and safety, of all interventions for hyperemesis gravidarum in pregnancy up to 20 weeks' gestation. New 2016/05 10.1002/14651858.CD010607.pub2 Hyperemesis gravidarum

174

Airways

To assess the efficacy and safety of any dose or duration of oral steroids versus any other dose or duration of oral steroids for adults and children with an asthma exacerbation. New 2016/05 10.1002/14651858.CD011801.pub2 Acute severe asthma

Asthma

175

Breast Cancer

To assess the effects of different types of breast implants on capsular contracture, surgical short- and long-term complications, postoperative satisfaction level and quality of life in women who have undergone reconstructive breast surgery after mastectomy. New 2016/05 10.1002/14651858.CD010895.pub2 Mastectomy

Breast cancer
Breast reconstruction

176

Pregnancy and Childbirth

To examine the effectiveness and safety of hypnosis for pain management during labour and childbirth. Unchanged 2016/05 10.1002/14651858.CD009356.pub3 Hypnotherapy in childbirth

Hypnotherapy
Hypnosis
Childbirth

177

Pregnancy and Childbirth

To assess the effects of a policy of labour induction at or shortly before term (37 to 40 weeks) for suspected fetal macrosomia on the way of giving birth and maternal or perinatal morbidity. Unchanged 2016/05 10.1002/14651858.CD000938.pub2 Hypnotherapy in childbirth

Large for gestational age
Childbirth

178

Public Health

To assess the health and well-being impacts on adults following participation in environmental enhancement and conservation activities. New 2016/05 10.1002/14651858.CD010351.pub2

179

Skin

To determine the efficacy and safety of the available options for the treatment of female pattern hair loss in women. Unchanged 2016/05 10.1002/14651858.CD007628.pub4 Frontal fibrosing alopecia

180

Tobacco Addiction

To assess the extent to which institutional smoking bans may reduce passive smoke exposure and active smoking, and affect other health-related outcomes. New 2016/05 10.1002/14651858.CD011856.pub2 Smoking ban

181

Heart

To determine the benefits and harms associated with the following.


1. A routine invasive versus a conservative or 'selective invasive' strategy for the management of unstable angina and non-ST elevation myocardial infarction (UA/NSTEMI) in the stent era.
2. A routine invasive strategy with and without glycoprotein IIb/IIIa receptor antagonists versus a conservative strategy for the management of UA/NSTEMI in the stent era.

Changed 2016/05 10.1002/14651858.CD004815.pub4 Myocardial infarction
Unstable angina

182

Anaesthesia, Critical and Emergency Care

To review the effects of psychological preparation on postoperative outcomes in adults undergoing elective surgery under general anaesthetic. New 2016/05 10.1002/14651858.CD008646.pub2 General anaesthesia

183

Stroke

To assess the effects of speech and language therapy (SLT) for aphasia following stroke. Changed 2016/06 10.1002/14651858.CD000425.pub4 Stroke

184

Musculoskeletal

To evaluate the effect of biologic interventions on fatigue in rheumatoid arthritis. New 2016/06 10.1002/14651858.CD008334.pub2 Rheumatoid arthritis

185

Airways

To compare the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids (ICS) as part of a patient-initiated action plan for home management of exacerbations in children and adults with persistent asthma. Unchanged 2016/06 10.1002/14651858.CD007524.pub4 Asthma

186

Public Health

To evaluate the beneficial and adverse effects of fortification of staple foods with zinc on health-related outcomes and biomarkers of zinc status in the general population. New 2016/06 10.1002/14651858.CD010697.pub2 Zinc

187

ENT

To assess the benefits and harms of oral antibiotics in children up to 18 years with OME. Unchanged 2016/06 10.1002/14651858.CD009163.pub3

188

Pain, Palliative and Supportive Care

To assess the efficacy and safety of paracetamol for the acute treatment of frequent episodic tension-type headache in adults. New 2016/06 10.1002/14651858.CD011889.pub2

189

Effective Practice and Organisation of Care

To evaluate the effects of programs that implement the IMCI strategy in terms of death, nutritional status, quality of care, coverage with IMCI deliverables, and satisfaction of beneficiaries. New 2016/06 10.1002/14651858.CD010123.pub2 Integrated Management of Childhood Illness

190

Effective Practice and Organisation of Care

To evaluate the effectiveness of intervention strategies to boost and sustain high childhood immunisation coverage in LMICs. (OPEN ACCESS) Changed 2016/07 10.1002/14651858.CD008145.pub3

191

Kidney and Transplant

The objective of this review is to evaluate the accuracy of two alternative imaging tests - the dimercaptosuccinic acid renal scan (DMSA) and renal-bladder ultrasound (RBUS) - in diagnosing VUR and high-grade VUR (Grade III-V VUR). New 2016/06 10.1002/14651858.CD010657.pub2

192

Metabolic and Endocrine Disorders

To assess the effects of short-acting insulin analogues versus regular human insulin in adults with type 1 diabetes. New 2016/06 10.1002/14651858.CD012161

193

Wounds

To assess the effects of skin antisepsis as part of central venous catheter care for reducing catheter-related blood stream infections (BSIs), catheter colonisation, and patient mortality and morbidities. New 2016/07 10.1002/14651858.CD010140.pub2

194

Neonatal

To determine the efficacy, effect of dose, method of administration and safety of sucrose for relieving procedural pain in neonates as assessed by validated composite pain scores, physiological pain indicators (heart rate, respiratory rate, saturation of peripheral oxygen in the blood, transcutaneous oxygen and carbon dioxide (gas exchange measured across the skin - TcpO2, TcpCO2), near infrared spectroscopy (NIRS), electroencephalogram (EEG), or behavioural pain indicators (cry duration, proportion of time crying, proportion of time facial actions (e.g. grimace) are present), or a combination of these and long-term neurodevelopmental outcomes. Unchanged 2016/07 10.1002/14651858.CD001069.pub5

195

Breast Cancer

To assess the effect of altered radiation fraction size for women with early breast cancer who have had breast conserving surgery. Unchanged 2016/07 10.1002/14651858.CD003860.pub4

196

Drugs and Alcohol

To assess the effects of motivational interviewing (MI) interventions for preventing alcohol misuse and alcohol-related problems in young adults. Unchanged 2016/07 10.1002/14651858.CD007025.pub4

197

Upper GI and Pancreatic Diseases To evaluate the efficacy and safety of molecular-targeted therapy , either alone or in combination with chemotherapy, in people with advanced gastric cancer. New 2016/07 10.1002/14651858.CD011461.pub2

198

Developmental, Psychosocial and Learning Problems 1. To establish whether group-based parenting programmes are effective in improving the emotional and behavioural adjustment of young children (maximum mean age of three years and 11 months); and

2. To assess whether parenting programmes are effective in the primary prevention of emotional and behavioural problems.

Changed 2016/08 10.1002/14651858.CD003680.pub3

199

Airways To assess the efficacy and safety of home telemonitoring with healthcare professional feedback between clinic visits, compared with usual care. New 2016/08 10.1002/14651858.CD011714.pub2

200

Vascular To investigate the ability of the D-dimer test to rule out a diagnosis of acute PE in patients treated in hospital outpatient and accident and emergency (A&E) settings who have had a pre-test probability (PTP) of PE determined according to a clinical prediction rule (CPR), by estimating the accuracy of the test according to estimates of sensitivity and specificity. The review focuses on those patients who are not already established on anticoagulation at the time of study recruitment. New 2016/08 10.1002/14651858.CD010864.pub2

201

Effective Practice and Organisation of Care To assess the effects of public sector regulation, training, or co-ordination of the private for-profit health sector in low- and middle-income countries. New 2016/08 10.1002/14651858.CD009855.pub2

202

Gynaecological, Neuro-oncology and Orphan Cancer To assess and compare the effects of music therapy and music medicine interventions for psychological and physical outcomes in people with cancer. Changed 2016/08 10.1002/14651858.CD006911.pub3

203

Effective Practice and Organisation of Care Our primary objective was to systematically summarise empirical evidence of the effects of strategies to reduce corruption in the health sector. Our secondary objective was to describe the range of strategies that have been tried and to guide future evaluations of promising strategies for which there is insufficient evidence. New 2016/08 10.1002/14651858.CD008856.pub2

204

Stroke To assess the effects of self management interventions on the quality of life of adults with stroke who are living in the community, compared with inactive or active (usual care) control interventions. New 2016/08 10.1002/14651858.CD010442.pub2 checkY

205

Neonatal To determine whether evidence is available to support the use of KMC in LBW infants as an alternative to conventional neonatal care before or after the initial period of stabilization with conventional care, and to assess beneficial and adverse effects. Unchanged 2016/08 10.1002/14651858.CD002771.pub4 Kangaroo care checkY - Article updated

206

Musculoskeletal To compare methotrexate and methotrexate-based DMARD combinations for rheumatoid arthritis in patients naïve to or with an inadequate response (IR) to methotrexate. New 2016/08 10.1002/14651858.CD010227.pub2

207

Vascular The aim of this review was to assess the efficacy of combined intermittent pneumatic leg compression (IPC) and pharmacological prophylaxis versus single modalities in preventing venous thromboembolism. Unchanged 2016/09 10.1002/14651858.CD005258.pub3

208

Tobacco Addiction To evaluate-the safety and effect of using ECs to help people Who smoke accomplish achieve long-term smoking abstinence. Unchanged 2016/09 10.1002/14651858.CD010216.pub3

209

Developmental, Psychosocial and Learning Problems To assess the effectiveness and safety of pain-relieving agents for reducing colic in infants younger than four months of age. New 2016/09 10.1002/14651858.CD009999.pub2

210

Public Health • To assess the impact of population-level interventions for dietary sodium reduction in government jurisdictions worldwide.

• To assess the differential impact of those initiatives by social and economic indicators.

New 2016/09 10.1002/14651858.CD010166.pub2

211

STI To assess the effects and safety of chlamydia screening versus standard care on chlamydia transmission and infection complications in pregnant and non-pregnant women and in men. New 2016/09 10.1002/14651858.CD010866.pub2

212

STI To assess the effectiveness in women and the safety in men of concurrent antibiotic treatment for the sexual partners of women treated for bacterial vaginosis. New 2016/10 10.1002/14651858.CD011701.pub2 Bacterial vaginosis checkY

213

Common Mental Disorders To assess the effects of psychological therapies in preventing PTSD and associated negative emotional, behavioural and mental health outcomes in children and adolescents who have undergone a traumatic event. New 2016/10 10.1002/14651858.CD012371 Mental disorder
Posttraumatic stress disorder

214

Pregnancy and Childbirth To assess the effects of immediate or early SSC for healthy newborn infants compared to standard contact on establishment and maintenance of breastfeeding and infant physiology. Unchanged 2016/11 10.1002/14651858.CD003519 Kangaroo care checkY - Article updated, may be other relevant articles also