Wikipedia:Picture peer review/Notable mutations

Notable mutations

Original - Selection of notable mutations, ordered in a standard table of the genetic code of amino acids. As can be seen, clinically important missense mutations generally change the properties of the amino acid residue between being basic, acidic, polar or nonpolar, while nonsense mutations result in a stop codon.

Links together the basic concept of the genetic code with some clinically important mutations. Colorful.

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Articles this image appears in

Mutation, Genetic code

Creator

Mikael Häggström

Nominated by

Mikael Häggström (talk) 08:00, 21 July 2009 (UTC)

Comments

• Appears to be well referenced. I can't make any strong comments as I don't have much knowledge in the area. I'd probably give it a whirl though. It could be a little clearer that the third base is represented by the row in each cell. Noodle snacks (talk) 01:23, 22 July 2009 (UTC)

Thanks for the comment. I've specified the 3rd base in each row.Mikael Häggström (talk) 05:51, 22 July 2009 (UTC)

• Comments: i. I wonder if the SVG shouldn't have a white bg too (transparency makes it bit hard to read); ii. I'd align the smaller boxes at the top with the right side of the big table; iii. some text alignment issues in the svg (hydrophobic runs outside border), but could be a thumbnailing issue as the 'fullsize' looked OK; iv. I haven't read the full text carefully, but what's with those random molecules scattered around the diagram? --jjron (talk) 08:04, 22 July 2009 (UTC)

I replaced the background with white in Inkscape, but it still turns out transparent in the browser, but only on the image description page, not when in Wikipedia mainspace or when clicking on it to view only the image in Firefox, so I think it's acceptable, since it's probably meant to make clear that it's actually a vector image. I gave some more space to hydrophobic, and also some to missense, nonsense etc, but they still cross the borders in the thumb, and if I compress them more they'll look weird in fullsize. As to the molecules, they are the coded amino acids for each codon. Putting the boxes to right made space for a descriptive box inside the image as well. Thanks for comments. Mikael Häggström (talk) 09:02, 22 July 2009 (UTC)

• Mutations that cause something such as sickle-cell anaemia will cause that phenotype in the cells, but something such as a missense mutation in cancer will only make one more susceptible to its development, so I would like to see something to clarify that. In addition, I think links to the diseases and/or genes in the description would be helpful. SiameseTurtle (talk) 11:55, 28 July 2009 (UTC)

Seconder