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Corneodesmosin

From Wikipedia, the free encyclopedia
CDSN
Identifiers
AliasesCDSN, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
External IDsOMIM: 602593; MGI: 3505689; HomoloGene: 48005; GeneCards: CDSN; OMA:CDSN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001264

NM_001008424
NM_001355275

RefSeq (protein)

NP_001255

NP_001008424
NP_001342204

Location (UCSC)Chr 6: 31.12 – 31.12 MbChr 17: 35.86 – 35.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.[5][6][7]

This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204539Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039518Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998). "Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes". J Biol Chem. 272 (50): 31770–6. doi:10.1074/jbc.272.50.31770. PMID 9395522.
  6. ^ Zhou Y, Chaplin DD (Nov 1993). "Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation". Proc Natl Acad Sci U S A. 90 (20): 9470–4. Bibcode:1993PNAS...90.9470Z. doi:10.1073/pnas.90.20.9470. PMC 47590. PMID 8415725.
  7. ^ a b "Entrez Gene: CDSN corneodesmosin".

Further reading

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