Fenticlor
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| Routes of administration | topical |
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| ECHA InfoCard | 100.002.336 |
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| Formula | C12H8Cl2O2S |
| Molar mass | 287.15 g·mol−1 |
| Melting point | 174 °C (345 °F) |
Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine.
Synthesis
[edit]It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride.[1] It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.[2][3]
Safety
[edit]The LD50 (rats, oral) of fenticlor is 3250 mg/kg.[1] It may cause photosensitivity.[4]
References
[edit]- ^ a b Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3527306732.
- ^ DE 568944, Muth F, "Verfahren zur Darstellung von Bis-(halogen-oxyaryl)-sulfiden", issued 1931, assigned to I. G. Farben
- ^ Dunning F, Dunning B, Drake WE (1931). "Preparation and Bacteriological Study of Some Symmetrical Organic Sulfides". Journal of the American Chemical Society. 53 (9): 3466–3469. doi:10.1021/ja01360a035.
- ^ Burry JN (June 1974). "Letter: Fenticlor, actinic reticuloid, and antihistamines". British Medical Journal. 2 (5918): 556–7. doi:10.1136/bmj.2.5918.556-c. PMC 1610938. PMID 4152080.
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