|Systematic (IUPAC) name|
|Trade names||pHisoHex, Gamophen, Septisol, Turgex, Germa-Medica, Hexachlorophane, Almederm|
|CAS Registry Number|
|Molecular mass||406.903503 g/mol|
|Melting point||163 to 165 °C (325 to 329 °F)|
|Boiling point||471 °C (880 °F)|
|Solubility in water||Insoluble in water. Soluble in acetone, ethanol, ether and chloroform. mg/mL (20 °C)|
Hexachlorophene, also known as Nabac, is an organochlorine compound that was once widely used as a disinfectant. The compound occurs as a white solid (although commercial samples can be off-white) and can be odorless or possess a slightly phenolic odor. In medicine, hexachlorophene is very useful as a topical anti-infective, anti-bacterial agent, often used in soaps and toothpaste. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide.
Commercialization and removal from U.S. market
||The examples and perspective in this article deal primarily with the United States and do not represent a worldwide view of the subject. (August 2015)|
In 1972, the U.S. Food and Drug Administration (FDA) halted the production and distribution of products containing more than 1% of hexachlorophene. After that point, most products that contain hexachlorophene were available only by prescription from a doctor. The restrictions were enacted after reports of 15 deaths in the United States and 39 deaths in France were reported following brain damage caused by hexachlorophene. 
At least two companies manufactured over-the-counter preparations incorporating hexachlorophene. One product was Baby Magic Bath by The Mennen Company. Mennen recalled the product in 1971, and it was removed from retail distribution. Immediately after the withdrawal, there was an outbreak of Staphylococcus infections in hospitals across the USA.
Two commercial preparations using hexachlorophene, pHisoDerm and pHisoHex, were widely used as effective antibacterial skin cleansers in the treatment of acne, with pHisoDerm developed for those allergic to the active ingredients in pHisoHex. In the US during the 1960s, both were available over the counter. After the ban was enacted, pHisoDerm was reformulated without hexachlorophene, and continued to be sold over-the-counter, while pHisoHex, which contained 3% hexachlorophene (three times the legal limit imposed in 1972), became available (and remain available today) as a prescription body wash. In the European Community countries during the 1970s and 1980s, pHisoHex was available over the counter. A related product, pHisoAc, was used as a skin mask to dry and peel away acne lesions. Another preparation, pHiso-Scrub, was a hexachlorophene-impregnated sponge for scrubbing, has since been discontinued. Several substitute products (including triclosan) were developed, but none had the germ-killing capability of hexachlorophene. Sanofi-Aventis was the sole manufacturer of pHisoHex, while The Mentholatum Company owns the pHisoDerm brand today. Sanofi-Aventis discontinued production of several forms of pHisoHex in August 2009 and discontinued all production of pHisoHex in September 2013.
Trade names for hexachlorophene include: Acigena, Almederm, AT7, AT17, Bilevon, Exofene, Fostril, Gamophen, G-11, Germa-Medica, Hexosan, Septisol, Surofene.
- Fiege, H.; Voges, H.-M.; Hamamoto, T; Umemura, S.; Iwata, T.; Miki, H.; Fujita, Y.; Buysch, H.-J.; Garbe, D.; Paulus, W. (2000). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry (Weinheim: Wiley-VCH). doi:10.1002/14356007.a19_313. ISBN 3-527-30673-0.
- Germicide Limit Stirs Confusion, New York Times, September 24, 1972, pg. 53.
- The Milwaukee Sentinel: "US Order Curbs Hexachlorophene" (UPI), September 23, 1972. From Google News.
- Ocala Star Banner, "15 Deaths Cited In Use of Germ Killer, Hexachlorophene" (AP), March 21, 1973. From Google News.
- Dixon, RE; Kaslow, RA; Mallison, GF; Bennett, JV (1973). "Staphylococcal disease outbreaks in hospital nurseries in the United States--December 1971 through March 1972". Pediatrics 51 (2): 413–7. PMID 4700144.
- "Hexachlorophene". PharmGKB. Retrieved 2012-012-28. Check date values in: