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Ricinine nitrilase

From Wikipedia, the free encyclopedia
ricinine nitrilase
Identifiers
EC no.3.5.5.2
CAS no.9075-40-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a ricinine nitrilase (EC 3.5.5.2) is an enzyme that catalyzes the chemical reaction

ricinine + 2 H2O 3-carboxy-4-methoxy-N-methyl-2-pyridone + NH3

Thus, the two substrates of this enzyme are ricinine and H2O, whereas its two products are 3-carboxy-4-methoxy-N-methyl-2-pyridone and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is ricinine aminohydrolase. This enzyme participates in nitrogen metabolism.

References

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  • ROBINSON WG, HOOK RH (1964). "Ricinine Nitrilase. I. Reaction Product and Substrate Specificity". J. Biol. Chem. 239: 4257–62. PMID 14247679.
  • HOOK RH, ROBINSON WG (1964). "Ricinine Nitrilase. Ii. Purification and Properties". J. Biol. Chem. 239: 4263–7. PMID 14247680.
  • Pace HC, Brenner C (2001). "The nitrilase superfamily: classification, structure and function". Genome Biol. 2 (1): REVIEWS0001. doi:10.1186/gb-2001-2-1-reviews0001. PMC 150437. PMID 11380987.