AMP deaminase

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AMPD1
Identifiers
Aliases AMPD1, MAD, MADA, MMDD, adenosine monophosphate deaminase 1
External IDs MGI: 88015 HomoloGene: 20 GeneCards: 270
RNA expression pattern
PBB GE AMPD1 206121 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172626
NM_000036

NM_001033303

RefSeq (protein)

NP_000027.2
NP_001166097.1

NP_001028475.2

Location (UCSC) Chr 1: 114.67 – 114.7 Mb Chr 3: 103.07 – 103.1 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene.[3][4]

Adenosine monophosphate deaminase is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia molecule in the process.

Function[edit]

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythrocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.[4]

A new research report shows that the widely prescribed diabetes medication metformin works on AMP kinase by directly inhibiting AMP deaminase, thereby increasing cellular AMP.[5]

Regulation[edit]

It has been shown that in environments with high potassium concentrations, AMP-deaminase is regulated by ATP and ADP through a “Km-type” mechanism. In low potassium ion concentrations, a mixed “Km V-type” of the regulation is observed.[6]

Pathology[edit]

A deficiency is associated with myoadenylate deaminase deficiency.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mahnke-Zizelman DK, Sabina RL (October 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J. Biol. Chem. 267 (29): 20866–77. PMID 1400401. 
  4. ^ a b EntrezGene 270
  5. ^ Ouyang J, Parakhia RA, Ochs RS (January 2011). "Metformin activates AMP kinase through inhibition of AMP deaminase". J. Biol. Chem. 286 (1): 1–11. doi:10.1074/jbc.M110.121806. PMC 3012963free to read. PMID 21059655. [unreliable medical source?]
  6. ^ Skladanowski, Andrzej (1979). "Potassium-dependent regulation by ATP and ADP of AMP-deaminase from beef heart". International Journal of Biochemistry. 10 (2): 177–181. doi:10.1016/0020-711X(79)90114-9. 

Further reading[edit]

External links[edit]