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5-guanidino-2-oxopentanoate decarboxylase

From Wikipedia, the free encyclopedia
5-guanidino-2-oxopentanoate decarboxylase
Identifiers
EC no.4.1.1.75
CAS no.56831-67-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme 5-guanidino-2-oxopentanoate decarboxylase (EC 4.1.1.75) catalyzes the chemical reaction

5-guanidino-2-oxo-pentanoate 4-guanidinobutanal + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-guanidino-2-oxo-pentanoate carboxy-lyase (4-guanidinobutanal-forming). Other names in common use include alpha-ketoarginine decarboxylase, and 2-oxo-5-guanidinopentanoate carboxy-lyase. It has 2 cofactors: thiamin diphosphate, and Divalent cation.

References

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  • Vanderbilt AS, Gaby NS, Rodwell VW (1975). "Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida". J. Biol. Chem. 250 (14): 5322–9. PMID 237915.