ANKRD1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ankyrin repeat domain 1 (cardiac muscle)
Identifiers
Symbols ANKRD1 ; ALRP; C-193; CARP; CVARP; MCARP; bA320F15.2
External IDs OMIM609599 MGI1097717 HomoloGene8289 GeneCards: ANKRD1 Gene
RNA expression pattern
PBB GE ANKRD1 206029 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27063 107765
Ensembl ENSG00000148677 ENSMUSG00000024803
UniProt Q15327 Q9CR42
RefSeq (mRNA) NM_014391 NM_013468
RefSeq (protein) NP_055206 NP_038496
Location (UCSC) Chr 10:
92.67 – 92.68 Mb
Chr 19:
36.11 – 36.12 Mb
PubMed search [1] [2]

Ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the ANKRD1 gene.[1][2]

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.[2]

Interactions[edit]

ANKRD1 has been shown to interact with Titin[3] and MYPN.[3][4]

References[edit]

  1. ^ Chu W, Burns DK, Swerlick RA, Presky DH (June 1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells". J Biol Chem 270 (17): 10236–45. doi:10.1074/jbc.270.17.10236. PMID 7730328. 
  2. ^ a b "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)". 
  3. ^ a b Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (November 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. (England) 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192. 
  4. ^ Bang, M L; Mudry R E; McElhinny A S; Trombitás K; Geach A J; Yamasaki R; Sorimachi H; Granzier H; Gregorio C C; Labeit S (April 2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". J. Cell Biol. (United States) 153 (2): 413–27. doi:10.1083/jcb.153.2.413. ISSN 0021-9525. PMC 2169455. PMID 11309420. 

Further reading[edit]