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Ankyrin repeat domain 1 (cardiac muscle)
Symbols ANKRD1 ; ALRP; C-193; CARP; CVARP; MCARP; bA320F15.2
External IDs OMIM609599 MGI1097717 HomoloGene8289 GeneCards: ANKRD1 Gene
RNA expression pattern
PBB GE ANKRD1 206029 at tn.png
More reference expression data
Species Human Mouse
Entrez 27063 107765
Ensembl ENSG00000148677 ENSMUSG00000024803
UniProt Q15327 Q9CR42
RefSeq (mRNA) NM_014391 NM_013468
RefSeq (protein) NP_055206 NP_038496
Location (UCSC) Chr 10:
92.67 – 92.68 Mb
Chr 19:
36.11 – 36.12 Mb
PubMed search [1] [2]

Ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the ANKRD1 gene.[1][2]

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.[2]


ANKRD1 has been shown to interact with Titin[3] and MYPN.[3][4]


  1. ^ Chu W, Burns DK, Swerlick RA, Presky DH (June 1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells". J Biol Chem 270 (17): 10236–45. doi:10.1074/jbc.270.17.10236. PMID 7730328. 
  2. ^ a b "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)". 
  3. ^ a b Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (November 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. (England) 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192. 
  4. ^ Bang, M L; Mudry R E; McElhinny A S; Trombitás K; Geach A J; Yamasaki R; Sorimachi H; Granzier H; Gregorio C C; Labeit S (April 2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". J. Cell Biol. (United States) 153 (2): 413–27. doi:10.1083/jcb.153.2.413. ISSN 0021-9525. PMC 2169455. PMID 11309420. 

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