Adenine deaminase

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adenine deaminase
EC number
CAS number 9027-68-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an adenine deaminase (EC is an enzyme that catalyzes the chemical reaction

adenine + H2O \rightleftharpoons hypoxanthine + NH3

Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2ICS.


  • Blauch M, Koch FC and Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem. 130: 471–486. 
  • Heppel LA, Hurwitz J and Horecker BL (1957). "Adenine deaminase of Azotobacter vinelandii". J. Am. Chem. Soc. 79 (3): 630–633. doi:10.1021/ja01560a033.