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Early life and education
He is the son of Alexander Hepple (1904-1983), who was Leader of the South African Labour Party, and Josephine Zwarenstein (1906-1992). He was educated at Jeppe High School for Boys (1947-1951), the University of the Witwatersrand (B.A.,1954, LLB cum laude and Society of Advocates Prize for Best Law Graduate, 1957), and the University of Cambridge (LLB, 1966, LLD 1993).
He was a Lecturer in Law at the University of the Witwatersrand (1959-62), and practised as an Advocate at the Johannesburg Bar (1962-63). He was active as a student leader against racial segregation in the universities, worked as an adviser and assistant in the South African Congress of Trade Unions, and participated in the underground struggle against apartheid. He acted as legal adviser to Nelson Mandela in his trial for incitement in 1962, and was himself arrested at Liliesleaf Farm, Rivonia, with leaders of the African National Congress and Communist Party on 11 July 1963. After 90-day detention without trial, he managed to escape to England from the subsequent Rivonia Trial in November 1963. He went as a graduate student to Clare College Cambridge (1964-1966) and was appointed to a lectureship in law at Nottingham University (1966-1968), returning to Cambridge as a Fellow of Clare College and University Lecturer (1969-1976). He became Professor of Social and Labour Law in the University of Kent at Canterbury (1976) and a Chairman of Industrial Tribunals (full-time 1977-82, part-time 1974-77, 1982-1993). He was appointed Professor of English Law at University College London (1982-93) and was Dean and Head of the Department of Laws at UCL (1989-1993). In 1993 he was elected Master of Clare College Cambridge (until 2003), and was appointed Professor of Law in the University (1995-2001). He was elected as a Fellow of the British Academy in 2003. He has been awarded honorary doctorates in law by the University of the Witwatersrand, University of Cape Town, University College London and the Universita degli Studi di Bari, Italy, and was Hon. Professor of Law in the University of Cape Town(1999-2006). The honour of Knight Bachelor was bestowed on him for services to legal studies in 2004. In 2013 he was awarded the first Labour Law Research Network Award for Distinguished Contributions to Labour Law. 
He is a Barrister and Bencher of Gray's Inn and was appointed Queen's Counsel (hon) in 1996. He practised successively at 2 Crown Office Row, Old Square Chambers and Blackstone Chambers until 2007. He served on the Lord Chancellor's Advisory Committee on Legal Education and Conduct (1994-1999)and Legal Services Panel (2000-2002). He was a Judge and Senior Vice-President of the UN Administrative Tribunal (2007-2009). He was a member of the Nuffield Council on Bioethics 2000–2003, Chair from 2003-2007. He also chaired the Council’s Working Parties on Genetics and human behaviour  (2000-2002) and The forensic use of bioinformation  (2006-2007). He was a member of the Commission for Racial Equality (1986-1990), a Trustee of the Canon Collins Educational Trust for South Africa (1989-2007),Chair of the European Roma Rights Centre, based in Budapest (2001-2007), and is Chair of the Equal Rights Trust, an international human rights organisation based in London (since 2007). He was elected Hon President of the Industrial Law Society in 2012.
He married Shirley Goldsmith in 1960 (dissolved 1994), with whom he had two children and four grandchildren. He married Mary Coussey in 1994, and has two stepchildren.
."Race, Jobs and the Law in Britain" (2nd ed 1970) ."The Making of Labour Law in Europe: [editor and contributor] (1986) ."Equality: a New Legal Framework? Independent Review of the Enforcement of UK Anti-Discrimination Legislation" [ with M. Coussey amd T.C.Choudhury](2000)
- Labour Laws and Global Trade(2005)
."The Transformation of Labour Law in Europe" [editor and contributor] (2009) ."Equality: the New Legal Framework" (2011) ."Alex Hepple:South African Socialist" (2011) ."Young Man with a Red Tie: a memoir of Mandela and the failed revolution 1960-1963"(2013)
- "''Genetics and human behaviour'' Nuffield Council on Bioethics' official website". Nuffieldbioethics.org. Retrieved 2013-12-09.
- "''The forensic use of bioinformation'' Nuffield Council on Bioethics' official website". Nuffieldbioethics.org. Retrieved 2013-12-09.