Bt cotton is a genetically modified variety of cotton producing an insecticide. It is produced by Monsanto. It is supplied in India's Maharashtra state by the agri-biotechnology company, Mahyco, as the distributor.
The bacterium Bacillus thuringiensis (Bt) is a family of over 200 different proteins which naturally produce chemicals harmful to selective insects, most notably the larvae of moths and butterflies, beetles, Helicoverpa armigera and flies, and harmless to other forms of life (Umt.edu, 2013). The gene coding for Bt toxin has been inserted into cotton, causing cotton to produce this natural insecticide in its tissues. In many regions, the main pests in commercial cotton are lepidopteran larvae, which are killed by the Bt protein in the transgenic cotton they eat. This eliminates the need to use large amounts of broad-spectrum insecticides to kill lepidopteran pests (some of which have developed pyrethroid resistance). This spares natural insect predators in the farm ecology and further contributes to noninsecticide pest management.
However, Bt cotton is ineffective against many cotton pests such as plant bugs, stink bugs, and aphids; depending on circumstances it may still be desirable to use insecticides in prevention of such pests. A 2006 study done by Cornell researchers, the Center for Chinese Agricultural Policy and the Chinese Academy of Science on Bt cotton farming in China found that after seven years these secondary pests that were normally controlled by pesticide had increased, necessitating the use of pesticides at similar levels to non-Bt cotton and causing less profit for farmers because of the extra expense of GM seeds.
How (Bt) Cotton Works
(Bt) cotton was created through the addition of genes encoding toxin crystals in the Cry group of endotoxin. When insects attack and eat the cotton plant the Cry toxins are dissolved. This is made possible due to the high pH level of the insects stomach. The now dissolved and activated Cry molecules bond to cadherin-like proteins on cells comprising the brush border molecules. The epithelium of the brush border membranes role is to separate the body cavity from the gut whilst allowing access for nutrients. The Cry toxin molecules attach themselves to specific locations on the cadherin-like proteins present on the epithelial cells of the midge and ion channels are formed which allow the flow of potassium. Regulation of potassium concentration is essential and if left unchecked causes death of cells. Due to the formation of Cry ion channels sufficient regulation of potassium ions is lost and results in the death of epithelial cells. The death of such cells creates gaps in the brush border membrane. The gaps then allow bacteria and (Bt) spores to enter the body cavity resulting in the death of the organism.
Bt Cotton in India
The use of Bt-Cotton in India has grown exponentially since its introduction. Recently India has become the number one global exporter of cotton and the second largest cotton producer in the world. India has also bred Bt-cotton varieties such as Bikaneri Nerma and hybrids such as (NHH-44), setting up India to benefit now and well into the future. Socio-economic surveys confirm that Bt-Cotton continues to deliver significant and multiple agronomic, economic, environmental and welfare benefits to Indian farmers and society including halved insecticide requirements and a doubling of yields. However India’s success has been subject to scrutiny. Monsanto's seeds are expensive and lose vigour after one generation, prompting The Indian Council of Agricultural Research to develop a cheaper Bt-Cotton variety with seeds that could be reused. The cotton incorporated the cry1Ac gene from the soil bacterium Bacillus thuringiensis (Bt), making the cotton toxic to bollworms. This variety showed poor yield and was removed within a year and also contained a DNA sequence owned by Monsanto, prompting an investigation. In parts of India cases of acquired resistance against Bt-Cotton have occurred. Monsanto has admitted that the pink bollworm is resistant to first generation transgenic Bt-Cotton that expresses the single Bt gene (Cry1Ac). 
In India, Bt cotton has been enveloped in controversies due to its supposed links with seed monopolies and farmer suicides. However, the link between the introduction of Bt Cotton to India and a surge in farmer suicides has been refuted by other studies, with farmer suicides actually having fallen since the introduction of Bt cotton. Bt cotton accounts for 93% of cotton grown in India.
Notes and references
- "Maharashtra lifts ban on Mahyco’s Bt cotton seeds". Nagpur. Indian Express. May 6, 2013. Retrieved 2013-09-03.
- Susan Lang (July 25, 2006). "Seven-year glitch: Cornell warns that Chinese GM cotton farmers are losing money due to 'secondary' pests". Cornell University.
- University of Montana. 2013. Bt Cotton. [online] Available at: http://www.umt.edu/ethics/Debating%20Science%20Program/ODC/Biotechnology/Alternatives/Bt%20Cotton1/default.aspx [Accessed: 6 Nov 2013].
- Choudhary, B. & Gaur, K. 2010. Bt Cotton in India: A Country Profile. ISAAA Series of Biotech Crop Profiles. ISAAA: Ithaca, NY
- James, Clive. 2009. Global Status of Commercialized Biotech/GM Crops: 2009. ISAAA Brief No.41. ISAAA: Ithaca, NY.
- Choudhary, B. & Gaur, K. 2010. Bt Cotton in India: A Country Profile. ISAAA Series of Biotech Crop Profiles. ISAAA: Ithaca, NY. James, Clive. 2009. Global Status of Commercialized Biotech/GM Crops: 2009. ISAAA Brief No.41. ISAAA: Ithaca, NY.
- Kadambini Gaur, Bhagirath Choudhary & (2010). Bt cotton in India - A country profile. New Delhi: ISAAA - The International Service for the Acquisition of Agri-biotech Applications.
- Bt cotton & Management of the Tobacco Budworm-Bollworm Complex. USA: U.S.Department of Agriculture. 2001.
- Vandana, Dr. Shiva; Afsar H. Jafri (Winter 2004). "Failure of GMOs in India". Research Foundation for Science, Technology and Ecology. Retrieved 27 September 2013.
- Gruere, Guillaume (2008). "Bt Cotton and farmer suicides in India: Reviewing the Evidence". International Food Policy Research Institute. Retrieved 24 February 2014.
- Plewis I (2014), "Indian farmer suicides: Is GM cotton to blame?" Significance, 11(1): 14-18
- Jayaraman, K.S (14 February 2012). "India investigates Bt cotton claims". Nature - International weekly journal of science. Retrieved 27 September 2013.