Carbonic anhydrase VI

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Carbonic anhydrase VI
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA6 ; CA-VI; GUSTIN
External IDs OMIM114780 MGI1333786 HomoloGene20324 ChEMBL: 3025 GeneCards: CA6 Gene
EC number
RNA expression pattern
PBB GE CA6 206873 at tn.png
More reference expression data
Species Human Mouse
Entrez 765 12353
Ensembl ENSG00000131686 ENSMUSG00000028972
UniProt P23280 P18761
RefSeq (mRNA) NM_001215 NM_009802
RefSeq (protein) NP_001206 NP_033932
Location (UCSC) Chr 1:
9.01 – 9.04 Mb
Chr 4:
150.19 – 150.2 Mb
PubMed search [1] [2]

Carbonic anhydrase 6 (also called 'Gustin') is an enzyme that in humans is encoded by the CA6 gene.[1][2]

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.[2] It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal.


  1. ^ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (Oct 1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenet Cell Genet 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177. 
  2. ^ a b "Entrez Gene: CA6 carbonic anhydrase VI". 

Further reading[edit]

  • Nishimori I, FujikawaAdachi K, Onishi S, Hollingsworth MA (1999). "Carbonic anhydrase in human pancreas: hypotheses for the pathophysiological roles of CA isozymes.". Ann. N. Y. Acad. Sci. 880: 5–16. doi:10.1111/j.1749-6632.1999.tb09505.x. PMID 10415846. 
  • Kivela J, Parkkila S, Parkkila AK et al. (1999). "Salivary carbonic anhydrase isoenzyme VI.". J. Physiol. (Lond.). 520 Pt 2: 315–20. doi:10.1111/j.1469-7793.1999.t01-1-00315.x. PMC 2269599. PMID 10523402. 
  • Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas.". Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 33 (1): 68–74. doi:10.1016/s1590-8658(01)80138-9. PMID 11303978. 
  • Breton S (2002). "The cellular physiology of carbonic anhydrases.". JOP 2 (4 Suppl): 159–64. PMID 11875253. 
  • Aldred P, Fu P, Barrett G et al. (1991). "Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry.". Biochemistry 30 (2): 569–75. doi:10.1021/bi00216a035. PMID 1899030. 
  • Parkkila S, Kaunisto K, Rajaniemi L et al. (1990). "Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands.". J. Histochem. Cytochem. 38 (7): 941–7. doi:10.1177/38.7.2113069. PMID 2113069. 
  • Murakami H, Sly WS (1987). "Purification and characterization of human salivary carbonic anhydrase.". J. Biol. Chem. 262 (3): 1382–8. PMID 2433278. 
  • Sutherland GR, Baker E, Fernandez KE et al. (1989). "The gene for human carbonic anhydrase VI(CA6) is on the tip of the short arm of chromosome 1.". Cytogenet. Cell Genet. 50 (2-3): 149–50. doi:10.1159/000132746. PMID 2505973. 
  • Ogawa Y, Hong SS, Toyosawa S et al. (1993). "Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II.". J. Histochem. Cytochem. 41 (3): 343–51. doi:10.1177/41.3.8429198. PMID 8429198. 
  • Kivelä J, Parkkila S, Waheed A et al. (1998). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum.". Clin. Chem. 43 (12): 2318–22. PMID 9439449. 
  • Thatcher BJ, Doherty AE, Orvisky E et al. (1998). "Gustin from human parotid saliva is carbonic anhydrase VI.". Biochem. Biophys. Res. Commun. 250 (3): 635–41. doi:10.1006/bbrc.1998.9356. PMID 9784398. 
  • Leinonen J, Kivelä J, Parkkila S et al. (1999). "Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle.". Caries Res. 33 (3): 185–90. doi:10.1159/000016515. PMID 10207193. 
  • Redman RS, Peagler FD, Johansson I (2000). "Immunohistochemical localization of carbonic anhydrases I, II, and VI in the developing rat sublingual and submandibular glands.". Anat. Rec. 258 (3): 269–76. doi:10.1002/(SICI)1097-0185(20000301)258:3<269::AID-AR6>3.0.CO;2-Y. PMID 10705347. 
  • Leinonen J, Parkkila S, Kaunisto K et al. (2001). "Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands.". J. Histochem. Cytochem. 49 (5): 657–62. doi:10.1177/002215540104900513. PMID 11304804. 
  • Karhumaa P, Leinonen J, Parkkila S et al. (2001). "The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11604–8. doi:10.1073/pnas.121172598. PMC 58776. PMID 11553764.