CA1 (gene)

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Carbonic anhydrase I
Protein CA1 PDB 1azm.png
PDB rendering based on 1azm.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA1 ; CA-I; CAB; Car1; HEL-S-11
External IDs OMIM114800 MGI88268 HomoloGene20414 IUPHAR: 2597 ChEMBL: 261 GeneCards: CA1 Gene
EC number
RNA expression pattern
PBB GE CA1 205949 at tn.png
PBB GE CA1 205950 s at tn.png
More reference expression data
Species Human Mouse
Entrez 759 12346
Ensembl ENSG00000133742 ENSMUSG00000027556
UniProt P00915 P13634
RefSeq (mRNA) NM_001128829 NM_001083957
RefSeq (protein) NP_001122301 NP_001077426
Location (UCSC) Chr 8:
86.24 – 86.29 Mb
Chr 3:
14.77 – 14.81 Mb
PubMed search [1] [2]

Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.[1][2]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including cellular respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.

They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.[2]


  1. ^ Lowe N, Edwards YH, Edwards M, Butterworth PH (Nov 1991). "Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8". Genomics 10 (4): 882–8. doi:10.1016/0888-7543(91)90176-F. PMID 1916821. 
  2. ^ a b "Entrez Gene: CA1 carbonic anhydrase I". 

Further reading[edit]