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Carbonic anhydrase VIII
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM114815 MGI88253 HomoloGene20861 ChEMBL: 2410 GeneCards: CA8 Gene
EC number
RNA expression pattern
PBB GE CA8 220234 at tn.png
More reference expression data
Species Human Mouse
Entrez 767 12319
Ensembl ENSG00000178538 ENSMUSG00000041261
UniProt P35219 P28651
RefSeq (mRNA) NM_004056 NM_007592
RefSeq (protein) NP_004047 NP_031618
Location (UCSC) Chr 8:
61.1 – 61.19 Mb
Chr 4:
8.14 – 8.24 Mb
PubMed search [1] [2]

Carbonic anhydrase-related protein is an enzyme that in humans is encoded by the CA8 gene.[1][2]

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.[2]


CA8 has been shown to interact with ITPR1.[3]


  1. ^ Nishikata M, Nishimori I, Taniuchi K, Takeuchi T, Minakuchi T, Kohsaki T, Adachi Y, Ohtsuki Y, Onishi S (Feb 2007). "Carbonic anhydrase-related protein VIII promotes colon cancer cell growth". Mol Carcinog 46 (3): 208–14. doi:10.1002/mc.20264. PMID 17219437. 
  2. ^ a b "Entrez Gene: CA8 carbonic anhydrase VIII". 
  3. ^ Hirota, Junji; Ando Hideaki; Hamada Kozo; Mikoshiba Katsuhiko (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". Biochem. J. (England) 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. ISSN 0264-6021. PMC 1223404. PMID 12611586. 

Further reading[edit]