Carbonic anhydrase-related protein is an enzyme that in humans is encoded by the CA8gene.
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
^Nishikata M, Nishimori I, Taniuchi K, Takeuchi T, Minakuchi T, Kohsaki T, Adachi Y, Ohtsuki Y, Onishi S (Feb 2007). "Carbonic anhydrase-related protein VIII promotes colon cancer cell growth". Mol Carcinog46 (3): 208–14. doi:10.1002/mc.20264. PMID17219437.
Bergenhem NC, Sait SS, Eddy RL et al. (1995). "Assignment of the gene for human carbonic anhydrase VIII(CA8) to chromosome 8q11→q12". Cytogenet. Cell Genet.71 (3): 299–300. doi:10.1159/000134131. PMID7587398.
Kelly C, Nógrádi A, Walker R et al. (1995). "Lurching, reeling, waddling and staggering in mice--is carbonic anhydrase (CA) VIII a candidate gene?". Biochem. Soc. Trans.22 (3): 359S. PMID7821612.
Skaggs LA, Bergenhem NC, Venta PJ, Tashian RE (1993). "The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue". Gene126 (2): 291–2. doi:10.1016/0378-1119(93)90385-G. PMID8482548.
Sjöblom B, Elleby B, Wallgren K et al. (1997). "Two point mutations convert a catalytically inactive carbonic anhydrase-related protein (CARP) to an active enzyme". FEBS Lett.398 (2–3): 322–5. doi:10.1016/S0014-5793(96)01263-X. PMID8977131.
Taniuchi K, Nishimori I, Takeuchi T et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain". Neuroscience112 (1): 93–9. doi:10.1016/S0306-4522(02)00066-0. PMID12044474.
Akisawa Y, Nishimori I, Taniuchi K et al. (2003). "Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer". Virchows Arch.442 (1): 66–70. doi:10.1007/s00428-002-0721-y. PMID12536316.