Complement component 2

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Complement component 2
Protein C2 PDB 2i6q.png
PDB rendering based on 2i6q.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols C2 ; ARMD14; CO2
External IDs OMIM613927 MGI88226 HomoloGene45 GeneCards: C2 Gene
EC number
RNA expression pattern
PBB GE C2 203052 at tn.png
More reference expression data
Species Human Mouse
Entrez 717 12263
Ensembl ENSG00000166278 ENSMUSG00000024371
UniProt P06681 P21180
RefSeq (mRNA) NM_000063 NM_013484
RefSeq (protein) NP_000054 NP_038512
Location (UCSC) Chr 6:
31.87 – 31.91 Mb
Chr 17:
34.86 – 34.9 Mb
PubMed search [1] [2]

Complement C2 is a protein that in humans is encoded by the C2 gene.[1] The protein encoded by this gene is part of the classical pathway of complement system.

In the "classical" pathway of complement activation, activated C1 cleaves C4a and C4b, and cleaves C2 into C2a and C2b. The complex of the large fragments of C2 and C4, called C4b2a, is the classical C3 convertase and can activate C3. Deficiency of C2 has been associated with certain autoimmune diseases.[1]


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