Complement factor B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Complement factor B
Protein CFB PDB 1dle.png
PDB rendering based on 1dle.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CFB ; AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2
External IDs OMIM138470 MGI105975 HomoloGene1292 ChEMBL: 5731 GeneCards: CFB Gene
EC number 3.4.21.47
RNA expression pattern
PBB GE CFB 202357 s at tn.png
PBB GE CFB 211920 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 629 14962
Ensembl ENSG00000204359 ENSMUSG00000090231
UniProt P00751 P04186
RefSeq (mRNA) NM_001710 NM_001142706
RefSeq (protein) NP_001701 NP_001136178
Location (UCSC) Chr 6:
31.9 – 31.92 Mb
Chr 17:
34.86 – 34.86 Mb
PubMed search [1] [2]
Alternative pathway. (Some labels are in Polish.)

Complement factor B is a protein that in humans is encoded by the CFB gene.[1]

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[1]

Complement tests
C4 (C) FB (A) C3 CH50 Conditions
 · PSG, C3 NeF AA
 ·  · HA, C4D
 ·  ·  · TCPD
 · /↓ SLE
inflammation

References[edit]

Further reading[edit]

External links[edit]