Complement factor B is a protein that in humans is encoded by the CFBgene.
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Arnason A, Larsen B, Marshall WH et al. (1977). "Very close linkage between HLA-B and Bf inferred from allelic association". Nature268 (5620): 527–8. doi:10.1038/268527a0. PMID889587.CS1 maint: Explicit use of et al. (link)
Yancey KB, Overholser O, Domloge-Hultsch N et al. (1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway". J. Invest. Dermatol.98 (3): 379–83. doi:10.1111/1523-1747.ep12499812. PMID1545147.CS1 maint: Explicit use of et al. (link)
Wu LC, Morley BJ, Campbell RD (1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements". Cell48 (2): 331–42. doi:10.1016/0092-8674(87)90436-3. PMID3643061.