CD11c

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Integrin, alpha X (complement component 3 receptor 4 subunit)
Protein ITGAX PDB 1n3y.png
PDB rendering based on 1n3y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGAX ; CD11C; SLEB6
External IDs OMIM151510 MGI96609 HomoloGene55493 ChEMBL: 4733 GeneCards: ITGAX Gene
RNA expression pattern
PBB GE ITGAX 210184 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3687 16411
Ensembl ENSG00000140678 ENSMUSG00000030789
UniProt P20702 Q9QXH4
RefSeq (mRNA) NM_000887 NM_021334
RefSeq (protein) NP_000878 NP_067309
Location (UCSC) Chr 16:
31.37 – 31.39 Mb
Chr 7:
128.13 – 128.15 Mb
PubMed search [1] [2]

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[1] [2]

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[1]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.