Damascus is a census-designated place (CDP) in southwestern Goshen Township in Mahoning County and northwestern Butler Township in Columbiana County in the U.S. state of Ohio. As of the 2010 census, it had a population of 443. Damascus has a post office, with the ZIP code of 44619. Its elevation is 1,211 feet (369 m), and it is located at 40°54′7″N 80°57′18″W / 40.90194°N 80.95500°W (40.9020031, -80.9550891). The community lies at the intersection of U.S. Route 62 and State Routes 173 and 534.
The Mahoning County portion of Damascus is part of the Youngstown–Warren–Boardman, OH-PA Metropolitan Statistical Area, while the Columbiana County portion is part of the East Liverpool–Salem Micropolitan Statistical Area.
Coordinates: 40°54′07″N 80°57′18″W / 40.90194°N 80.95500°W