Datura inoxia (thorn-apple, downy thorn-apple, Indian-apple, moonflower, sacred datura, nacazcul, toloatzin, tolguache or toloache) is a species in the family Solanaceae. It is native to Central and South America, and introduced in Africa, Asia, Australia and Europe. The scientific name is often cited as D. innoxia. When English botanist Philip Miller first described the species in 1768, he misspelled the Latin word innoxia (inoffensive) when naming it D. inoxia. The name Datura meteloides was for some time erroneously applied to some members of the species, but that name has now been abandoned.
Datura inoxia is an annual shrubby plant that typically reaches a height of 0.6 to 1.5 metres. Its stems and leaves are covered with short and soft grayish hairs, giving the whole plant a grayish appearance. It has elliptic entire-edged leaves with pinnate venation. All parts of the plant emit a foul odor similar to rancid peanut butter when crushed or bruised, although most people find the fragrance of the flowers to be quite pleasant when they bloom at night.
The fruit is an egg-shaped spiny capsule, about 5 cm in diameter. It splits open when ripe, dispersing the seeds. Another means of dispersal is by the fruit spines getting caught in the fur of animals, who then carry the fruit far from the mother plant. The seeds have hibernation capabilities, and can last for years in the soil. The seeds, as well as the entirety of this plant, act as deliriants, but have a high probability of overdose.
All parts of Datura plants contain dangerous levels of poison and may be fatal if ingested by humans and other animals, including livestock and pets. In some places it is prohibited to buy, sell or cultivate Datura plants.
Cultivation and uses 
Datura inoxia, like other Datura species, contains the highly toxic alkaloids atropine, hyoscine (scopolamine), and hyoscyamine. The Aztecs called the plant toloatzin, and used it long before the Spanish conquest of Mexico for many therapeutic purposes, such as poultices for wounds where it acts as an anodyne. Although the Aztecs warned against madness and "various and vain imaginings", many native Americans have used the plant as an entheogen for hallucinations and rites of passage. The alkaloids of these plants are very similar to those of mandrake, deadly nightshade, and henbane, which are also highly poisonous plants used cautiously for effective pain relief in antiquity. Datura intoxication typically produces a complete inability to differentiate reality from fantasy (delirium, as contrasted to hallucination); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis with resultant painful photophobia that can last several days. Pronounced amnesia is another commonly reported effect. There can easily be a 5:1 variation in toxins from plant to plant, and a given plant's toxicity depends on its age, where it is growing, and local weather conditions. These wide variations make Datura exceptionally hazardous to use as a drug. In traditional cultures, users needed to have a great deal of experience and detailed plant knowledge so that no harm resulted from using it. Such knowledge is not available in modern cultures, so many unfortunate incidents result from ingesting Datura. In the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting Datura.
It has also been planted throughout the world as an ornamental plant for its attractive large leaves, large white flowers, and distinctive thorny fruit. However, the plant is now considered an invasive species in several locations. For example, because of the similarity of its life cycle to that of cotton, it is a pest in cotton fields. It is also a potential seed contaminant.
Similar species 
Datura inoxia is quite similar to Datura metel, to the point of being confused with it in early scientific literature. D. metel is a closely related Old World plant for which similar effects were described by Avicenna in eleventh century Persia. The closely related Datura stramonium differs in having smaller flowers and tooth-edged leaves, and Datura wrightii in having wider, 5-toothed (instead of 10-toothed) flowers. Datura inoxia differs from D. stramonium, D. metel & D.fastuosa in having about 7 to 10 secondary veins on either side of the midrib of the leaf which anastomose by arches at about 1 to 3 mm. from the margin. No anastomosis of the secondary veins are seen in the other 4 major species of Datura.
- Preissel, Ulrike; Hans-Georg Preissel (2002). Brugmansia and Datura: Angel's Trumpets and Thorn Apples. Buffalo, New York: Firefly Books. pp. 117–119. ISBN 1-55209-598-3.
- Richard Evans Schultes (1970-01-01). "The plant kingdom and hallucinogens (part III)". pp. 25–53. Retrieved 2007-05-23.
- "Erowid Datura Vault : Effects". Erowid. Retrieved 1 June 2010.
- "Suspected Moonflower Intoxication (Ohio, 2002)". CDC. Retrieved September 30, 2006.
- A. Alon, ed. in chief, Plants and Animals of the Land of Israel, Vol. 11: Flowering Plants B., p. 92; ed. M. Raviv and D. Heler; Ministry of Defence Publications and the Society for Protection of Nature (in Hebrew), 1983.
|Wikimedia Commons has media related to: Datura inoxia|
- USDA PLANTS Profile: Datura inoxia Miller
- USDA Germplasm Resources Information Network (GRIN): Datura inoxia Mill.