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The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the death receptor family of apoptosis-inducing cellular receptors. The typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
Signaling pathway of
TNF-R1. Dashed grey lines represent multiple steps
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