Death-inducing signaling complex
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Signaling pathway of
TNF-R1. Dashed grey lines represent multiple steps
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
[edit] References
- ^ Kischkel, FC; Hellbardt, S, Behrmann, I, Germer, M, Pawlita, M, Krammer, PH, Peter, ME (1995 Nov 15). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO journal 14 (22): 5579–88. PMID 8521815.
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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| Fas path |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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