Inoue Masashige (井上 政重?, 1585–1662) was an important figure during the early Edo period in Japan. He played a role in the persecution and eradication of Christians in Japan and he was commissioner for the Dutch East India Company in Nagasaki.
Masashige died in 1661 (not 1662). He is thought to have risen to prominence as lover of the shogun, Tokugawa Iemitsu, and certainly, he is one of the most prominent gay, or homosexual, figures in early-modern Japanese history. He and the shogun remained close throughout their lives, though on Iemitsu's death Masashige did not take his own life, as many of Iemitsu closest associates did. In his post of Grand Councillor (ômetsuke), Masashige had many encounters with the Dutch East India Company, who recorded much about him. One of the Company's employees, Olof Eriksson Willman, a Swede, recorded that Masashige tried to sleep with him, though Willman asserts he rebuffed him.
- Blussé, Leonard (2003). "The grand inquisitor Inoue Chikugano Kami Masashige, spin doctor of the Tokugawa Bakafu", Bulletin of Portuguese/Japanese Studies, vol. 7. Universidade Nova de Lisboa p.23-43
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