It begins at US-281 in Sawyer and travels southeast to Isabel where it rides the Barber/Pratt county line until it enters Kingman County, where it passes through Nashville, Zenda, and Spivey. North of Rago it intersects K-14 then continues on to pass through Norwich.
After entering Sedgwick County, it passes through Viola where K-49's northern terminus is. It continues northeast into south Wichita and intersects I-235 at Exit 5. It continues northeast where it terminates at US-54 and US-400.