The elevated station first opened on 24 April 1906, as part of the extension of line 2 Sud (2 South) from Passy to Place d'Italie. On 14 October 1907, line 2 Sud was incorporated into line 5. On 12 October 1942 the section of line 5 between Étoile and Place d'Italie, including La Motte-Picquet Grenelle, was transferred to Line 6.
On 13 July 1913, underground platforms were opened as part of the original section of line 8 between Beaugrenelle (now Charles Michels) and Opéra via La Motte-Picquet Grenelle. The section of line 8 from La Motte-Picquet Grenelle to Charles Michels and Porte d'Auteuil was transferred to line 10 on 27 July 1937 when line 8 was extended to Balard and an underground track for line 10 was opened linking La Motte-Picquet Grenelle with Duroc.