After the breakup of Aqua, Lene continued as a soloist. In 2003, she released her first album, Play with Me. It marked a change in her musical style, from the bubblegum sound of Aqua to a more R&B-influenced style. It reached number 30 on Denmark's chart and 74 on Norway's chart.[specify] The album single "Virgin Superstar" was given some radio airplay, but did not chart. Her next single, "It's Your Duty", was released on 8 September. It peaked at number 3 on Denmark's chart and number 9 on Norway's chart.[specify] In 2004, she released the single "Pretty Young Thing", which did not chart. She released a limited vinyl promo of "Here We Go" to DJs and radio, and a limited CD promo of "Scream".
Lene and Xenomania co-wrote two Girls Aloud songs, and although they did not appear on Lene's own album, the tracks "No Good Advice" and "You Freak Me Out" appeared on the Girls Aloud debut album Sound of the Underground. "No Good Advice" became a breakout hit for the group.
This section requires expansion with: collaborations with Benefic and Lazyboy. (November 2012)
On 26 October 2007, Lene and Soren Rasted reunited with the other members of Aqua, and solicited opportunities for a summer concert tour. After fielding offers by record companies in Denmark, Canada, United States, and United Kingdom, they settled with an eight concert tour in Denmark as part of the 2008 Grøn Koncert festival.
Lene continued with work with Aqua; they released a new track, "Back to the 80's", on 25 May 2009. They released their greatest hits album on 15 June, which featured the track, along with sixteen remastered tracks and two other new songs, "My Mamma Said" and "Live Fast, Die Young". From May to August, they toured Scandinavia and performed at several gigs in Germany, the UK, and France. The greatest hits CD was released in North America and many European countries on 22 September, and in the UK on 29 September.