|Type||Publicly traded Aktieselskab|
|Traded as||OMX: LUN|
|Key people||Mats Pettersson (Chairman), Ulf Wiinberg (President and CEO)|
|Revenue||DKK 16.0 billion (2011)|
|Operating income||DKK 3.357 billion (2010)|
|Profit||DKK 2.466 billion (2010)|
|Total assets||DKK 18.01 billion (end 2010)|
|Total equity||DKK 11.12 billion (end 2010)|
|Employees||6,000 (average, 2011)|
H. Lundbeck A/S (commonly known simply as Lundbeck) is a Danish international pharmaceutical company engaged in the research and development, production, marketing, and sale of drugs for the treatment of disorders in the central nervous system (CNS), including depression, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy and insomnia.
Headquartered in Copenhagen, Denmark Lundbeck has international production facilities in Denmark, Mexico, Italy and France and affiliates or sales offices in 57 countries. Lundbeck employs around 6.000 people globally (as of 2011), and the company’s products are registered in more than 100 countries world wide.
In 2011, the company's revenue was DKK 16.007 billion (€1.97 billion).
Lundbeck is listed on the Copenhagen Stock Exchange (CSE).
Lundbeck is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA) and of the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA)
The company was founded by Hans Lundbeck in 1915, and was initially a trading company supplying a variety of goods to the Danish market, including machinery for manufacturing, aluminium foil, artificial sweeteners, and photographic equipment.
Lundbeck entered the pharmaceutical market in 1924, importing medicines and cosmetics from companies based in other European and American countries. By the late 1930s, Lundbeck had begun to produce its own medicinal products and had established its own research department. Production continued during the Second World War, although it was limited due to a lack of raw materials.
After the war, Lundbeck continued to grow and in 1957 the company introduced Truxal (chlorprothixene) for the treatment of schizophrenia, entering the market for brain disorders. In 1954, the Lundbeck Foundation was established to maintain and expand the activities of Lundbeck Group and also to provide funding for scientific research of the highest quality. From the late 1970s and up through the 1980s, Lundbeck diverted its old agency business and thus became a dedicated pharmaceutical company focusing on the production of drugs used to treat disorders and diseases of the central nervous system. In 1989, Lundbeck launched the antidepressant Celexa (citalopram), which became the cornerstone for the company’s international expansion and in 2009 Lundbeck, bought Ovation and established a commercial platform in the USA.
Lundbeck manufactures drugs as:
|Brand name||INN||Drug class||Indication(s)||Notes|
|Azilect||Rasagiline||MAOB inhibitor||Parkinson's disease|
|Brintellix||Vortioxetine||SRI multimodal antidepressant (described as "serotonin modulator and stimulator")||Major depressive disorder|
|Buronil, Bunil||Melperone||Atypical antipsychotic
(of butyrophenone class)
|Psychosis, including schizophrenia|
|Chemet||Succimer||Heavy metal chelator||Lead poisoning in children||Use is limited to patients with blood lead levels above 45 μg/dL.|
|Cipramil, Celexa||Citalopram||SSRI||Major depressive disorder
|Cipralex, Lexapro||Escitalopram||SSRI||Major depressive disorder
Generalized anxiety disorder (GAD)
|(S)-enantiomer of citalopram.|
(of thioxanthene class)
|Psychosis, including schizophrenia||Cis-isomer of clopenthixol (a predecessor drug).|
|Deanxit||Flupentixol/melitracen||Typical antipsychotic / Tricyclic antidepressant||Moderate-to-severe depression associated with anxiety and/or agitation|
|Desoxyn||Methamphetamine||Stimulant (substituted amphetamine)||ADHD
Treatment-resistant exogenous obesity
|Use in obesity is limited to patients in whom obesity is resistant to other drugs.|
|Ebixa||Memantine||NMDA receptor antagonist||Alzheimer's disease|
|Fluanxol||Flupentixol||Thioxanthene typical antipsychotic||Psychosis, including schizophrenia|
|Nortrilen, Sensoval||Nortriptyline||Tricyclic antidepressant||Depression
|Active metabolite of amitriptyline.|
|Onfi||Clobazam||Benzodiazepine anticonvulsant and anxiolytic||Seizures associated with Lennox-Gastaut syndrome||Outside the US, approved for anxiety and treatment-resistant epilepsy.|
|Peganone||Ethotoin||Anticonvulsant||Epilepsy (tonic-clonic and complex partial seizures)|
(GABA transaminase inhibitor)
|Treatment-resistant epilepsy (complex partial seizures and West syndrome)||Use is restricted to resistant and refractory epilepsy due to the risk of irreversible vision loss.|
|Saroten||Amitriptyline||Tricyclic antidepressant||Depression (both unipolar and bipolar)
|Selincro||Nalmefene||Opioid receptor antagonist||Reduction of alcohol consumption in alcohol dependence (in combination with psychosocial support)||Only be used in patients with high drinking risk (at initial assessment and 2 weeks later), in those who do not have physical withdrawal symptoms or require immediate detoxification|
|Serdolect||Sertindole||Atypical antipsychotic||Psychosis, including schizophrenia|
|Truxal||Chlorprothixene||Thioxanthene typical antipsychotic||Psychosis, including schizophrenia||In some other countries approved for menopausal depression, insomnia and resistant nausea/vomiting.|
|Xenazine, Nitoman||Tetrabenazine||VMAT2 inhibitor||Chorea associated with Huntington's disease
Products under development
- Brexpiprazole — an atypical antipsychotic with aripiprazole-like core structure (D2 partial agonist).
- Intravenous formulation of carbamazepine.
- Desmoteplase — a thrombolytic (recombinant tissue plasminogen activator).
- Lu AE58054 — a 5-HT6 antagonist for Alzheimer's disease and schizophrenia-related cognitive deficit.
- Tedatioxetine — a triple reuptake inhibitor.
- Zicronapine — an atypical antipsychotic.
Lundbeck formerly held the only license to manufacture pentobarbital in the United States. The drug has been chosen as a substitute for sodium thiopental in the three drug cocktail used for execution by lethal injection in the nation. After coming under criticism for not adding an ‘end user’ agreement to prevent importers from selling Nembutal® to American prisons for use in executions, Lundbeck announced that it would not sell Nembutal to prisons in U.S. states that carry out executions. By introducing a new distribution system, Nembutal will be supplied exclusively through a specialty pharmacy drop ship program that will deny distribution of the product to prisons in U.S. states currently active in carrying out the death penalty by lethal injection.  In December Lundbeck divested a portfolio of products including Nembutal to US pharmaceutical company Akorn Inc. As part of the agreement, Akorn committed to continue with Lundbeck's restricted distribution program for Nembutal, which was implemented to restrict the use of the product in the US.
On June 19, 2013, the European Commission imposed a fine of €93.8 million on Lundbeck and fined several producers of generic pharmaceuticals a total of €52.2 million after Lundbeck made agreements in 2002 with the other companies to delay less expensive generics of Lundbeck's citalopram from entering the market. In return for the ability to maintain a monopoly on the drug's manufacture, Lundbeck offered payments and other kickbacks.
- Tarenflurbil, which the company had arranged for EU distribution rights on prior to termination of its development by Myriad.
- Desmoteplase, a novel, highly fibrin-specific thrombolytic agent in phase III of clinical development.
- "Annual Report 2010". Lundbeck. Retrieved 11 April 2011.
- "Lundbeck's "Serotonin Modulator and Stimulator" Lu AA21004: How Novel? How Good? - GLG News".
- "DESOXYN® C-II (methamphetamine HCl tablets, USP). Prescribing information." Lundbeck Inc., 2009. Revised May, 2009. 
- "Sabril® (vigabatrin) Tablets. Prescribing information." Lundbeck Inc., 2012. Revised February 2012. 
- "Execution drug still available after Lundbeck shuns ‘end user’ agreements". The Copenhagen Post. 1 April 2011. Retrieved 3 July 2011.
- "Lundbeck Seeks to Curb Use of Drug in Executions". The Wall Street Journal. 1 July 2011. Retrieved 3 July 2011.