A Los Angeles native, Werb attended Stanford. He is a UCLA Film School graduate.
His frequent collaborator is Michael Colleary. The duo won a Saturn Award for Best Writing for Face/Off in 1998. They previously worked on projects "Top Ten", "Stretch Armstrong" and "King's Ransom" (the latter one for director John Woo), but neither of these films were produced. He is the creator of Unnatural History.