Nasal sprays can come in a variety of forms such as medicated (Afrin) and natural (SinuSoothe). They are used as local treatments for conditions such as nasal congestion and allergic rhinitis. In some situations, nasal delivery route is preferred because it provides an agreeable alternative to injection or pills. Substances can be assimilated extremely quickly and directly through the nose. Many pharmaceutical drugs exist as nasal sprays for systemic administration (e.g. treatments for pain, migraine, osteoporosis and nausea). Other applications include hormone replacement therapy, treatment of Alzheimer's disease and Parkinson's disease. Nasal sprays are seen as a more efficient way of transporting drugs with potential use in crossing the blood brain barrier 
Saline nasal sprays
Saline sprays are typically non medicated. A mist of saline solution containing sodium chloride is delivered to help moisturize dry or irritated nostrils. This is a form of nasal irrigation. They can also relieve nasal congestion and remove airborne irritants such as pollen and dust thereby providing sinus allergy relief.
Three types of nasal sprays preparations of sodium chloride are available including hypertonic (3% sodium chloride or sea water), isotonic (0.9% sodium chloride) and hypotonic (0.65% sodium chloride). Isotonic solutions have the same salt concentration as the human body, whereas hypertonic solutions have a higher salt content and hypotonic solutions have a lower salt content. Isotonic saline nasal sprays are commonly used in infants and children to washout the thick mucus from the nose in case of allergic rhinitis. Hypertonic solutions may be more useful at drawing moisture from the mucus membrane and relieving nasal congestion.
Natural nasal sprays that include chemical complexes derived from plant sources such as ginger, capsaicin and tea-tree oil are also available. There is however, no trial-verified evidence that they have a measurable effect on symptoms.
Antihistamine nasal sprays
Antihistamines work by competing for receptor sites to block the function of histamine, thereby reducing the inflammatory effect.
List of antihistamine nasal sprays:
- Azelastine hydrocholoride and
- Olopatadine hydrochloride are the only antihistamines available as a nasal spray.
Topical decongestant nasal sprays
Decongestant nasal sprays are available over-the-counter in the United States, New Zealand, and the UK, work to very quickly open up nasal passages by constricting blood vessels in the lining of the nose. Prolonged use of these types of sprays can damage the delicate mucous membranes in the nose. This causes increased inflammation, an effect known as rhinitis medicamentosa or the rebound effect. As a result, decongestant nasal sprays are advised for short-term use only, preferably 5 to 7 days at maximum. Some doctors advise to use them 3 days at maximum. A recent clinical trial has shown that a corticosteroid nasal spray, may be useful in reversing this condition.
List of topical nasal decongestant:
Corticosteroid nasal sprays
Corticosteroid nasal sprays can be used to relieve the symptoms of sinusitis, hay fever, allergic rhinitis and non-allergic (perennial) rhinitis. They can reduce inflammation and histamine production in the nasal passages thereby relieving nasal congestion, runny nose, itchy nose and sneezing. They have been clinically proven however they can cause side effects such as headaches, nausea and nose bleeds.
List of corticosteroid nasal sprays:
- Fluticasone propionate
- Fluticasone furoate
- Beclomethasone dipropionate
- Triamcinolone acetonide
Nonsteroidal anti-inflammatory nasal sprays
Ketorolac tromethamin is the first and only NSAID nasal spray which is an effective non-narcotic alternative for patients who require pain relief at the opioid level.
Combination nasal spray
Combination use of two medications as nasal spray preparation has been frequently prescribed by doctors.
List of combination nasal sprays:
Nasal spray flu immunization
- Vaidyanathan S, Williamson P, Clearie K, Kahn F, Lipworth B (July 2010). Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion 182 (1). pp. 19–24. doi:10.1164/rccm.200911-1701OC. PMID 20203244.
- Rb Berkowitz, Di Bernstein, C LaForce, Aj Pedinoff, Ar Rooklin, Crv Damaraju, B Mesarina-wicki, Kb Nolop. Onset of action of mometasone furoate nasal spray (NASONEX) in seasonal allergic rhinitis. doi:10.1034/j.1398-9995.1999.00713.x.