PSMC6

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Proteasome (prosome, macropain) 26S subunit, ATPase, 6
Identifiers
Symbols PSMC6 ; CADP44; HEL-S-73; P44; SUG2; p42
External IDs OMIM602708 MGI1914339 HomoloGene100630 GeneCards: PSMC6 Gene
RNA expression pattern
PBB GE PSMC6 201699 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5706 67089
Ensembl ENSG00000100519 ENSMUSG00000021832
UniProt P62333 P62334
RefSeq (mRNA) NM_002806 NM_025959
RefSeq (protein) NP_002797 NP_080235
Location (UCSC) Chr 14:
53.17 – 53.2 Mb
Chr 14:
45.33 – 45.35 Mb
PubMed search [1] [2]

26S protease regulatory subunit S10B is an enzyme that in humans is encoded by the PSMC6 gene.[1][2][3]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.[3]

References[edit]

  1. ^ Fujiwara T, Watanabe TK, Tanaka K, Slaughter CA, DeMartino GN (Aug 1996). "cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family". FEBS Lett 387 (2-3): 184–8. doi:10.1016/0014-5793(96)00489-9. PMID 8674546. 
  2. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (Mar 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  3. ^ a b "Entrez Gene: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6". 

Further reading[edit]