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Proteasome (prosome, macropain) 26S subunit, ATPase, 6
Symbols PSMC6 ; CADP44; HEL-S-73; P44; SUG2; p42
External IDs OMIM602708 MGI1914339 HomoloGene100630 GeneCards: PSMC6 Gene
RNA expression pattern
PBB GE PSMC6 201699 at tn.png
More reference expression data
Species Human Mouse
Entrez 5706 67089
Ensembl ENSG00000100519 ENSMUSG00000021832
UniProt P62333 P62334
RefSeq (mRNA) NM_002806 NM_025959
RefSeq (protein) NP_002797 NP_080235
Location (UCSC) Chr 14:
53.17 – 53.2 Mb
Chr 14:
45.33 – 45.35 Mb
PubMed search [1] [2]

26S protease regulatory subunit S10B is an enzyme that in humans is encoded by the PSMC6 gene.[1][2][3]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.[3]


  1. ^ Fujiwara T, Watanabe TK, Tanaka K, Slaughter CA, DeMartino GN (Aug 1996). "cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family". FEBS Lett 387 (2-3): 184–8. doi:10.1016/0014-5793(96)00489-9. PMID 8674546. 
  2. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (Mar 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  3. ^ a b "Entrez Gene: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6". 

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