|Classification and external resources|
Pappataci fever (also known as Phlebotomus fever and, somewhat confusingly, sandfly fever and three-day fever) is a vector-borne febrile arboviral infection caused by three serotypes of Phlebovirus. Occurs in subtropical regions of the Eastern Hemisphere. The name, pappataci fever, comes from the Italian word for sandfly, it is the union of the word "pappa" (food) and taci (silent) which distinguish these insect from mosquitoes which produce a typical noise while flying.
Pappataci fever is prevalent in the subtropical zone of the Eastern Hemisphere between 20°N and 45°N, particularly in Southern Europe, North Africa, the Balkans, Eastern Mediterranean, Iraq, Iran, Pakistan, Afghanistan and India.
The disease is transmitted by the bites of phlebotomine sandflies of the Genus Phlebotomus, in particular, Phlebotomus papatasi, Phlebotomus perniciosus and Phlebotomus perfiliewi. The sandfly becomes infected when biting an infected human in the period between 48 hours before the onset of fever and 24 hours after the end of the fever, and remains infected for its lifetime. Besides this «horizontal» virus transmission from man to sandfly, the virus can be transmitted in insects transovarially, from an infected female sandfly to its offspring.
Pappataci fever is seldom recognised in endemic populations because it is mixed with other febrile illnesses of childhood, but it is more well-known among immigrants and military personnel from non-endemic regions.
Clinical course 
A few days after the infective bite, a feeling of lassitude, abdominal distress and chills develop followed by fever of 39°C to 40°C, severe frontal headaches, muscle and joint aches, flushing of the face and tachycardia. After two days the fever begins to subside and the temperature returns to normal. Fatigue, bradycardia and subnormal blood pressure may persist from few days to several weeks but complete recovery is the rule.
Although commercial tests are not readily available, diagnosis can be confirmed by serology-based assays or real-time PCR by laboratories that have developed assays to perform such identification.
There is no specific treatment for the disease.
Prevention of sandfly bites, and control of sandflies and their breeding grounds with insecticides are the principal methods for prevention. Mosquito nets may not be sufficient to prevent sandfly bites.
- Encyclopaedia Britannica.. "Pappataci fever" (in en). Retrieved 2009-07-03.
- Gratz N.G. (2004). The vector-borne human diseases in Europe. Their distribution and burden on public health. Copenhagen, Denmark. pp. 25–6.
- Tesh, R.B. (1984). "Transovarial transmission of arboviruses in their invertebrate vectors". In K.F. Harris. Current topics in vector research 2. pp. 57–76. ISBN 0-275-91433-X.
- Sabin A.B. (1955). "Recent advances in our knowledge of dengue and sandfly fever". American Journal of Tropical Medicine and Hygiene 4 (2): 198–207. PMID 14361897.
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