Phosphatidyl ethanolamine methyltransferase

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Phosphatidylethanolamine N-methyltransferase
External IDs OMIM602391 MGI104535 HomoloGene6291 GeneCards: PEMT Gene
EC number,
Species Human Mouse
Entrez 10400 18618
Ensembl ENSG00000133027 ENSMUSG00000000301
UniProt Q9UBM1 Q61907
RefSeq (mRNA) NM_001267551 NM_001290011
RefSeq (protein) NP_001254480 NP_001276940
Location (UCSC) Chr 17:
17.41 – 17.5 Mb
Chr 11:
59.97 – 60.05 Mb
PubMed search [1] [2]

Phosphatidyl ethanolamine methyltransferase (or Phosphatidylethanolamine N-methyltransferase) also known as PEMT is an enzyme which in humans is encoded by the PEMT gene.[1][2][3]


The PEMT enzyme converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17.[3]

See also[edit]


  1. ^ Walkey CJ, Shields DJ, Vance DE (January 1999). "Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2". Biochim. Biophys. Acta 1436 (3): 405–12. doi:10.1016/s0005-2760(98)00147-7. PMID 9989271. 
  2. ^ Vance DE, Li Z, Jacobs RL (November 2007). "Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology". J. Biol. Chem. 282 (46): 33237–41. doi:10.1074/jbc.R700028200. PMID 17881348. 
  3. ^ a b "Entrez Gene: PEMT". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.