Phosphatidyl ethanolamine methyltransferase

Phosphatidylethanolamine N-methyltransferase
Identifiers
Symbols	PEMT; MGC2483; PEAMT; PEMPT; PEMT2; PNMT
External IDs	OMIM: 602391 MGI: 104535 HomoloGene: 6291 GeneCards: PEMT Gene
EC number	2.1.1.17
Gene Ontology Molecular function • phosphatidylethanolamine N-methyltransferase activity • phosphatidylethanolamine binding • transferase activity Cellular component • membrane fraction • mitochondrion • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane • brush border membrane • mitochondrial membrane • sarcolemma Biological process • lipid metabolic process • glycerophospholipid metabolic process • phosphatidylcholine biosynthetic process • cell proliferation • negative regulation of cell proliferation • phospholipid biosynthetic process • response to vitamin • response to drug • response to amino acid stimulus • response to ethanol • S-adenosylhomocysteine metabolic process • S-adenosylmethionine metabolic process • positive regulation of lipoprotein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10400	18618
Ensembl	ENSG00000133027	ENSMUSG00000000301
UniProt	Q9UBM1	Q61907
RefSeq (mRNA)	NM_007169.2	NM_008819.2
RefSeq (protein)	NP_009100.2	NP_032845.2
Location (UCSC)	Chr 17: 17.41 – 17.5 Mb	Chr 11: 59.78 – 59.86 Mb
PubMed search	[1]	[2]

Phosphatidyl ethanolamine methyltransferase also known as PEMT is an enzyme which in humans is encoded by the PEMT gene.

Function

The PEMT enzyme converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17.

See also

• Phosphatidylethanolamine

Further reading

• Zemunik T, Boban M, Lauc G, et al. (2009). "Genome-wide Association Study of Biochemical Traits in Korčula Island, Croatia". Croat. Med. J. 50 (1): 23–33. doi:10.3325/cmj.2009.50.23. PMC 2657564. PMID 19260141. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2657564. 
• Mostowska A, Hozyasz KK, Wojcicki P, et al. (2009). "Associations of folate and choline metabolism gene polymorphisms with orofacial clefts". J. Med. Genet. 47 (12): 809–15. doi:10.1136/jmg.2009.070029. PMID 19737740. 
• Song J, da Costa KA, Fischer LM, et al. (2005). "Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)". FASEB J. 19 (10): 1266–71. doi:10.1096/fj.04-3580com. PMC 1256033. PMID 16051693. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1256033. 
• Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA (2009). "Genetic variants in phosphatidylethanolamine N-methyltransferase (PEMT) and methylenetetrahydrofolate dehydrogenase (MTHFD1) influence biomarkers of choline metabolism when folate intake is restricted". J Am Diet Assoc 109 (2): 313–8. doi:10.1016/j.jada.2008.10.046. PMC 2655101. PMID 19167960. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2655101. 
• da Costa KA, Kozyreva OG, Song J, et al. (2006). "Common genetic polymorphisms affect the human requirement for the nutrient choline". FASEB J. 20 (9): 1336–44. doi:10.1096/fj.06-5734com. PMC 1574369. PMID 16816108. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1574369. 
• Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046. 
• Vance DE, Walkey CJ, Cui Z (1997). "Phosphatidylethanolamine N-methyltransferase from liver". Biochim. Biophys. Acta 1348 (1–2): 142–50. PMID 9370326. 
• Dong H, Wang J, Li C, et al. (2007). "The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population". J. Hepatol. 46 (5): 915–20. doi:10.1016/j.jhep.2006.12.012. PMID 17391797. 
• Resseguie M, Song J, Niculescu MD, et al. (2007). "Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes". FASEB J. 21 (10): 2622–32. doi:10.1096/fj.07-8227com. PMC 2430895. PMID 17456783. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2430895. 
• Li H, Zhang H, Liu L, et al. (2009). "No association of the rs4646396 SNP in the PEMT locus with schizophrenia in a Chinese case-control sample". Psychiatry Res 169 (2): 176–7. doi:10.1016/j.psychres.2008.11.004. PMID 19647326. 
• Caudill MA, Dellschaft N, Solis C, et al. (2009). "Choline Intake, Plasma Riboflavin, and the Phosphatidylethanolamine N-Methyltransferase G5465A Genotype Predict Plasma Homocysteine in Folate-Deplete Mexican-American Men with the Methylenetetrahydrofolate Reductase 677TT Genotype". J. Nutr. 139 (4): 727–33. doi:10.3945/jn.108.100222. PMC 2714377. PMID 19211833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2714377. 
• Shields DJ, Lingrell S, Agellon LB, et al. (2005). "Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase". J. Biol. Chem. 280 (29): 27339–44. doi:10.1074/jbc.M504658200. PMID 15927961. 
• Liu Y, Zhang H, Ju G, et al. (2007). "A study of the PEMT gene in schizophrenia". Neurosci. Lett. 424 (3): 203–6. doi:10.1016/j.neulet.2007.07.038. PMID 17720317. 
• Shields DJ, Altarejos JY, Wang X, et al. (2003). "Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase". J. Biol. Chem. 278 (37): 35826–36. doi:10.1074/jbc.M306308200. PMID 12842883. 
• Xu X; Gammon MD; Zeisel SH; et al.; Wetmur, J. G.; Teitelbaum, S. L.; Bradshaw, P. T.; Neugut, A. I. et al (2008). "Choline metabolism and risk of breast cancer in a population-based study". FASEB J. 22 (6): 2045–52. doi:10.1096/fj.07-101279. PMC 2430758. PMID 18230680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2430758. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tessitore L, Marengo B, Vance DE, et al. (2003). "Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas". Oncology 65 (2): 152–8. doi:10.1159/000072341. PMID 12931022. 
• Jun DW, Han JH, Jang EC, et al. (2009). "Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans". Eur J Gastroenterol Hepatol 21 (6): 667–72. doi:10.1097/MEG.0b013e3283196adc. PMID 19262398. 
• Chen SN, Cilingiroglu M, Todd J, et al. (2009). "Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis". BMC Med. Genet. 10: 111. doi:10.1186/1471-2350-10-111. PMC 2775733. PMID 19878569. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2775733. 

External links

• MeSH Phosphatidylethanolamine+N-Methyltransferase

This article incorporates text from the United States National Library of Medicine, which is in the public domain.