Will Harridge worked as a railway ticket clerk before being hired in 1911 as the personal secretary to AL president Ban Johnson. In 1927, he became American League secretary. He became president of the American League in 1931, held that post until his retirement in 1958, and then was named president emeritus. At that point the league office was moved to New York City, and Harridge was allowed to keep the Chicago office as well as act as custodian of the American League archive correspondence.
Harridge often cited a 1932 incident as his most difficult decision in baseball. During a July 4 game between the New York Yankees and Washington Senators, a collision occurred at home plate involving Senators outfielder Carl Reynolds and Yankees catcher Bill Dickey. Dickey dropped the ball, but chased down Reynolds and punched him, resulting in a broken jaw. Though Dickey was a star player with the most powerful franchise in baseball, Harridge issued him a $1,000 fine and a thirty-day suspension.
He is more widely known, however, for a ruling that he made in 1951 when dwarf Eddie Gaedel signed a contract with Bill Veeck's St. Louis Browns. Gaedel registered one career plate appearance in August of that year, earning a walk on four straight balls. Harridge decided that Veeck was making a mockery of baseball and he cancelled Gaedel's contract the next day.