Sawallisch was born in Munich on August 26, 1923. At the age of five, he was already playing the piano and by the time he was ten, he had decided he wanted to become a concert pianist. As a child, he was greatly influenced by Richard Strauss and Hans Knappertsbusch.
At first, he studied composition and pianoforte privately. During the Second World War, he served in the Wehrmacht in France and Italy and in the closing stages of the war was detained at a British POW camp. After the war, he continued his studies at the Munich Hochschule für Musik where he passed his final examination for conducting.
He began his career at the opera house in Augsburg in 1947. At first he held the position of répétiteur and later became the principal conductor. In 1949, he was awarded the first prize at the Geneva International Music Competition where he accompanied the violinist Gerhard Seitz. In 1952–53 he was the personal assistant to Igor Markevitch at the International Summer Academy of the Mozarteum in Salzburg, Austria.
He was only 30 when he conducted the Berlin Philharmonic Orchestra, where Herbert von Karajan was then the principal conductor. When he debuted at the Bayreuth Festspielhaus conducting Tristan und Isolde in 1957, he was the youngest conductor ever to appear there.
After turning down offers to join the Vienna Philharmonic Orchestra and the New York Metropolitan Opera, Sawallisch became the Principal Conductor of the Vienna Symphony in 1960, a post he held for ten years. In 1961, he started conducting the Hamburg Symphony Orchestra and did this for ten years as well. From 1970 to 1980, he was the Music Director of the Orchestre de la Suisse Romande, succeeding Ernest Ansermet who had died the previous year. From 1971 to 1992, he was also the Music Director of the Bavarian State Opera, and for several years from 1983, he was concurrently its general manager.
For thirty years, he was closely associated with musical events in Munich. Here he conducted practically all of the major Richard Strauss operas, Salome being the sole exception. He also conducted 32 complete Richard Wagner Ring des Nibelungen cycles and is credited with nearly 1200 opera performances in the city alone.
In 1966, Eugene Ormandy, the music director of the Philadelphia Orchestra from 1936 to 1980, had invited Sawallisch to visit him. Sawallisch subsequently made several recordings there and in 1993 he succeeded Riccardo Muti as the Music Director of the Philadelphia Orchestra, where he remained until 2003 when he had to relinquish the post for health reasons. However, he remained its Conductor Laureate, a title he held for the rest of his life. He was also Honorary Conductor Laureate of the NHK Symphony Orchestra, Tokyo and for over 30 years he appeared with the orchestra annually in Tokyo. He was the recipient of a Suntory Music Award in 1993.
After his tenure with the Philadelphia Orchestra, Sawallisch returned for guest-conducting appearances in Philadelphia and at Carnegie Hall. However, ill health related to orthostatic hypotension prevented Sawallisch from conducting in subsequent years. In an article in The Philadelphia Inquirer of 27 August 2006, Sawallisch himself stated his retirement from the concert podium:
"It can happen without announcement that my blood pressure is too low. This instability gives me the necessity to finish my career after 57 years of concert and opera conducting."
Earlier, in 1988, he had published his autobiography "Im Interesse der Deutlichkeit" (For the Sake of Clarity) in which he had expounded his views on the role of a conductor.
Sawallisch was an honorary member of The Robert Schumann Society. In 2003, he helped to establish a music school in Grassau, Bavaria, naming the school the Wolfgang Sawallisch Stiftung (Wolfgang Sawallisch Foundation). He himself continued to live on his estate in Grassau in retirement.
Sawallisch and his wife Mechthild were married for 46 years until her death in 1998. Cardinal Joseph Ratzinger ( later Pope Benedict XVI ), a family friend, officiated at her Requiem Mass. She had a son, Jörg, from her previous marriage, whom Sawallisch had adopted. Jörg died in January 2013.
Sawallisch has been acclaimed as an interpreter of the music of Richard Strauss. As a pianist, he accompanied a number of prominent singers in lieder, including Dietrich Fischer-Dieskau, Dame Elisabeth Schwarzkopf and Dame Margaret Price. He has also been acclaimed for his interpretations of the symphonies of Anton Bruckner.
Sawallisch also recorded, as piano accompanist, Franz Schubert's Winterreise and Robert Schumann's Liederkreis and other songs with Thomas Hampson. One of his most celebrated live concert appearances as a pianist was on 11 February 1994 in Philadelphia, when Sawallisch substituted for the Philadelphia Orchestra at an all-Wagner concert on the night that a severe snow storm prevented much of the orchestra from arriving at the Academy of Music.
Sawallisch's recordings for EMI include highly regarded issues of Richard Strauss's Capriccio and the four symphonies of Robert Schumann with the Dresden Staatskapelle. He made a quadrophonic stereo album (probably the only one ever made) of Mozart's The Magic Flute in 1973 for EMI, starring Peter Schreier as Tamino, Walter Berry as Papageno, Edda Moser as the Queen of the Night, Anneliese Rothenberger as Pamina, and Kurt Moll as Sarastro. Other recordings (EMI, Orfeo, Phillips, and Sony) include:
- Ludwig van Beethoven's nine symphonies with the Royal Concertgebouw Orchestra, Amsterdam
- Johannes Brahms' Ein Deutsches Requiem with the Bavarian Radio Symphony Orchestra and Chorus
- Johannes Brahms's four symphonies with the London Philharmonic Orchestra
- Johannes Brahms's four symphonies with the Wiener Symphoniker
- Anton Bruckner's Symphonies 1, 4, 5, 6 & 9
- Antonín Dvořák's Requiem, and Stabat Mater, both with the Czech Philharmonic; Symphonies Nos. 7–9 and Cello Concerto with the Philadelphia Orchestra
- Felix Mendelssohn's Symphony No. 2 with the Berlin Philharmonic and Düsseldorf Chorus
- Franz Schubert's 9 Symphonies with Staatskapelle Dresden; Sacred Choral Works with the Bavarian Radio Symphony Orchestra and Chorus
- Richard Strauss's Intermezzo, Elektra, Friedenstag and Die Frau ohne Schatten, Arabella with the Bavarian State Opera
- Richard Strauss's Ein Heldenleben, Symphonia domestica, and Also sprach Zarathustra with The Philadelphia Orchestra
- Richard Strauss's Horn Concertos, with Dennis Brain and the Philharmonia Orchestra
- Giuseppe Verdi's Macbeth (live recording, Salzburg Festival)
- Richard Wagner's Der Ring des Nibelungen, Die Meistersinger von Nürnberg, Die Feen with the Bavarian State Opera; The Flying Dutchman (Bayreuth Festival and Bavarian State Orchestra, the latter filmed) and Lohengrin (Bayreuth Festival)
- Richard Wagner's Wesendonck Lieder with Marjana Lipovsek and The Philadelphia Orchestra
- Antonín Dvořák Symphony No. 4, Op. 88 (Philharmonia Orchestra), Columbia Records LP 33 SX 1034, sleevenote
- Stephen Moss (19 May 2000). "Old school titan". The Guardian (UK). Retrieved 8 August 2007.
- Anthony Tommasini (15 January 2004). "Channeling Bruckner, Maestro Illuminates Elusive Score". The New York Times. Retrieved 8 August 2007.
- Ben Mattison (31 March 2006). "Report: Wolfgang Sawallisch Has Retired". Playbill Arts. Retrieved 11 January 2008.
- Peter Dobrin, "At home with the maestro". Philadelphia Inquirer, 27 August 2006.
- James R. Oestreich (4 May 2003). "A 79-Year-Old Champion of Youth". New York Times. Retrieved 11 January 2008.
- Peter Crimmins (25 February 2013). "Maestro Sawallisch, who led Philadelphia Orchestra for a decade, dies at 89". NewsWorks. Retrieved 27 February 2013.
- Edward Rothstein (17 May 1995). "A Cheery, Old-World 'Ariadne'". New York Times. Retrieved 8 August 2007.
- Anne Midgette (5 August 2001). "Music: A Musical Capital Looks to America". New York Times. Retrieved 8 August 2007.
- Paul Horsley (1 April 2003). "A Hero's Tenure". Playbill Arts. Retrieved 11 January 2008.
- Anthony Tommasini (15 January 2004). "Channeling Bruckner, Maestro Illuminates Elusive Score". New York Times. Retrieved 11 January 2008.
- Lesley Valdes and Peter Dobrin (13 February 1994). "Snow or no snow, the show went on". Philadelphia Inquirer.
- Tom Di Nardo (28 February 1994). "Bons mots instead of notes from Maestro". Philadelphia Daily News.
- Nadine Brozan (15 February 1994). "Chronicle". New York Times. Retrieved 11 January 2008.
- Allan Kozinn (19 October 2002). "Back to Schumann, With Care and Passion". The New York Times. Retrieved 8 August 2007.
-  obituary - with a film about Sawallisch with an interview by Marty Moss Coane (fall 2007)
- Wolfgang Sawallisch at AllMusic
- Wolfgang Sawallisch at The Remington Site
- Wolfgang Sawallisch Foundation
- Interview with Wolfgang Sawallisch by Bruce Duffie, May 2, 1994
- František Sláma (musician) Archive. More on the history of the Czech Philharmonic between the 1940s and the 1980s: Conductors