Talk:Aspartame controversy

Agree to neutrality disputation

The article is clearly written in favor of Aspartame. I also agree that the Sweet Misery documentary contains very notable information and sources that lend considerable credit to reports of serious health side effects and collusion between members of the FDA and the makers of Aspartame. —Preceding unsigned comment added by 76.193.77.7 (talk) 08:35, 4 February 2009 (UTC)

I agree as well. The tone is definitely not neutral. —Preceding unsigned comment added by 69.133.96.67 (talk) 21:48, 25 February 2009 (UTC)

I agree, more information about the papers published by the scientific community in peer-reviewed articles should be added, and the request made by important toxicologists to the FDA to review the last findings from Istituto Ramazzini should be cited in the lead. Letters from scientists in COI should be removed from the page. (Karloff (talk) 22:08, 28 February 2009 (UTC))

There absolutely should be mention of the revolving door between the FDA and Monsanto. I think this information is vital and speaks volumes of the credibility of Monsanto's biased research and the forced decisions made by the FDA. —Preceding unsigned comment added by 68.148.10.125 (talk) 05:47, 2 March 2009 (UTC)

I too agree that this article seems unbalanced, also, going over the history of this article it seems that a substantial amount of information that would be beneficial for the debate has been taken out. While seemingly specious sources and references have been kept in: http://www.ctahr.hawaii.edu/oc/freepubs/pdf/FST-3.pdf is unreachable at the moment but by reading it via google's HTML cache I can see that it does not seem a source of good information: http://209.85.173.132/search?q=cache:AywoCftL8ocJ:www.ctahr.hawaii.edu/oc/freepubs/pdf/FST-3.pdf+FST-3.pdf . It has no sources and seems to contain information that is in direct contradiction to scientific research. For example: Claim: Aspartame causes increases in appetite and weight. Compare to http://www.webmd.com/diet/news/20050613/drink-more-diet-soda-gain-more-weight. 125.26.244.225 (talk) 05:55, 8 March 2009 (UTC)

These disease hypotheses, combined with allegations of conflicts of interest in the approval process—which were refuted by an official US governmental enquiry[6]—have been the focus of vocal activism and conspiracy theories regarding the possible risks of aspartame. Is that a joke? if you read that source you will see that at least 5 of the people involved with Aspartame while at working at HHS were later employed by Grocery Manufacturers of America, National Soft Drink Association or directly working for Searle as legal counsel. How do you manage to interpret that as 'refuting' conflicts of interest? Unomi (talk) 15:40, 8 March 2009 (UTC)

Ethanol as antidote for methanol

On a recent revert of an added source by Monte to the article, I don't see the original research. However, Monte's research has been criticized. PMID 3300262 (freely accessible) notes references 49, 50 critiquing Monte. I had access to PMID 4065772, which was a letter to the editor by a Searle scientist who said that "because ethanol is metabolized much more rapidly than methanol, any 'protective' effect in food sources will be pharmacokinetically evanescent. For example, the 'protective' effect of ethanol in 500 ml orange juice can be shown to persist for less than 1 min after a simultaneous aspartame dose of 200 mg/kg". I don't have access to Monte's work. II | (t - c) 18:57, 22 January 2009 (UTC)

After I made that revert I realized I should have added WP:SYNTH violation. The whole section seems to reek of it. While we can't usually use a letter to the editor as a source, if it is true, and there is no reason to doubt it, then we should be careful not to include dubious information if we aren't certain. If we can find a V & RS that clears this up, maybe we can use it. Right now it looks like we are publishing anti-aspartame OR that may not be true as part of a section of anti-aspartame SYNTH propaganda. It seems to be a theoretical problem, but where's the evidence that it's really a serious problem for anyone? Where's the research? I'd like to hear other's views on this. -- Fyslee (talk) 01:18, 23 January 2009 (UTC)

In the sweet misery movie, it also claims that methanol in food/beverage is bound to pectins that prevent absorption - it isn't just ethanol having a protective effect. As for the claim that the alcohol is metabolized by the body in under a minute, any drinker should question that assertion. It should also be pointed out that Searle is comparing 200mg/kg of Aspartame, an amount much higher than the ADI, to 500ml of orange juice that would contain only a small amount of methanol and ethanol. It is also an apples to oranges comparison as the original claim was that ethanol in natural beverages counteracted the methanol naturally occurring in those beverages - not aspartame, in any quantity, let alone the draconian quantities used. There would be about 0.4mg of methanol and 190mg ethanol in 500ml of fresh orange juice [1], though after prolonged storage it could be 31mg methanol and 242mg ethanol. Ethanol, like most substances, is eliminated (Blood alcohol content) from the bloodstream more or less in proportion to its concentration but elimination saturates at about 10g/hour (30g/hour for drinkers with high tolerance). At low levels, below saturation, one should think in terms of half lives in the body.

200mg/kg of Aspartame in a 70kg person is 14000mg of aspartame or about 1400mg of methanol from aspartame (at 10%) - an amount that in juice would be counteracted by (at 8:1 ratio) by 11200mg of ethanol, not the mere 242mg or less contained in a pint of orange juice. They are comparing the toxin level equivalent to 46 pints of old orange juice or 3500 pints of fresh OJ to the protective level found in only one pint, even if we ignore the slight of hand of substituting aspartame for methanol when attempting to refute an argument about naturally occurring methanol. Or, to put it another way, they are comparing the toxic effect of 78 cans of diet soda (or 3500 pints of fresh OJ) to the protective effect of one pint of OJ. Searle could also have further manipulated the outcome in their favor by the choice of fresh/old orange juice and the use of heavy drinkers. And ultimately they are comparing an 8:1 to 475:1 ethanol:methanol (naturally occuring) ratio vs a 1:5.7 to 1:7.3 ratio of ethanol:methanol (from aspartame). Thus, their comparison is based on ratios that differ from natural conditions by a factor of 45 to 3467 - i.e. 1.6 to 3.5 orders of magnitude. The protective effect is highly dependent on the ratios. In addition to ethanol and pectins, orange juice would also contain vitamin C and other antioxidants. Methanol has a half life of around 2-3 hours without ethanol andand more than an order of magnitude greater with high concentrations of ethanol [2]. Since the high relative concentrations of ethanol would take many ethanol half lives to reduce to the point where it ceases to be protective, the longer protection time afforded by realistic concentrations of ethanol will reduce the rate at which methanol is converted to formaldehyde and one would expect the effective instantaneous dose of formaldehyde would be lower. "There is typically a delay of the toxic symptoms [of methanol] anywhere from six-30 hours and longer if ethanol has been co-ingested." (ibid). Indeed, ethanol is one of the primary medical treatments for methanol poisoning (also combined with dialysis). Whitis (talk) 03:28, 2 March 2009 (UTC)

In order to sort this out, it's important to be clearer about what the objections are and how policy informs our editing decisions. And it sounds as if there is confusion about what original research means in wikipedia policy. It refers specifically to claims, opinions, arguments, or comparisons produced by wikipedia's editors, and aren't found made in published sources. It's acceptable for Monte to conduct original research. It's not acceptable for wikipedians to use their own original research. Monte can claim anything he likes, and wikipedians aren't really in a position to judge his facts or arguments. If they're his opinions, we must attribute the opinions to him, and not take them to be broad statements of fact or opinion of anyone but him. We're also to judge is how much weight Monte's published opinions carry in the field, and we do that by a surveying the body of relevant published literature on the subject. And in terms of this article, the relevant published literature would be about the issues and people who claim aspartame is harmful and those who disagree with them. So if the Searle response letter is criticizing a claim made by Monte, they're both relevant to this article. The ultimate question is, are Monte's claims or the letter published response given much weight? That's the issue, because how much weight they're given and by whom determines how much weight to give their claims in this article. Original research isn't the issue. But weight is. The fringe guideline might give good guidance here also. Hope this helps. Professor marginalia (talk) 22:46, 23 January 2009 (UTC)

Unencyclopedic Ramazzini section

The Ramazzini subsection is unencyclopedic, with a nearly interminable back-and-forth between defenders and detractors of the Ramazzini group. The Ramazzini study also is not in the same category as the other two studies cited. We are talking here about a poorly-controlled primary research study of rats compared with meta-analysis (Negri) and a large-scale human epi study (NCI).

The Ramazzini group is one group that has reported results, mostly in one journal, differing from those of the wider scientific community. Multiple regulatory agencies have criticised its methodologies and the validity of its conclusions. There is no reason--apart from ideological prejudice, i.e. POV--to include it here. Although I initially just tried to pare it down to a more appropriate size, I finally opted for removing it entirely. If it is restored, then, please, only in drastically reduced form. Keepcalmandcarryon (talk) 21:50, 26 January 2009 (UTC)

Not only did you vandalize the Ramazzini section, you ultimately removed the whole section without any debate nor consent from the contributing editors here. Of course the industry was extremely unhappy with the independent research done by a highly respected organization that has conducted research for more than 30 years. To counter strike, the industry paid millions again to "prove" aspartame is really safe and came with the severely flawed review by the Burdock Group consultants. They flood the scientific community with 1-day studies to determine long-term effects, which we all know is impossible. The Ramazzini is the only and largest research done that investigated the long-term effects of aspartame intake, and did that according to valid scientific protocols. What you say is your OPINION about Ramazzini and that's not an argument to remove it. And let me quote the Wikipedia meaning of Controversy here:

A controversy or dispute is a commencement of a conflict between statements of accepted fact and a new or unaccepted proposal that disagrees with, argues against, or debates the accepted knowledge or opinion. Controversies can range in scope from private disputes between two individuals to large-scale disagreements between societies.

And this is not a paper encyclopedia, there's no reason to shorten anything if it's valid. Immortale (talk) 22:21, 26 January 2009 (UTC)

The Ramazzini study had a very high statistical power due to its large population of rats (much larger than previous studies), and the Ramazzini foundation is notable and experienced in carcinogenic studies according to the NYTimes [3]:

While Dr. Soffritti's methods have drawn some criticism, the Ramazzini cancer lab, which is financed by private bank foundations, governments and 17,000 individual members, has earned considerable credibility since it was founded in 1971 for its pioneering research on chemicals. It was the first research body to do studies showing that vinyl chloride and the gasoline additive methyl tertiary-butyl ether, or M.T.B.E., are carcinogenic, research that eventually encouraged the United States to strictly regulate vinyl chloride and that led 21 states to ban M.T.B.E.

You also questionably removed a secondary source from EHP which stated that Ramazzini had a better than standard methodology; no reason for that removal is stated here. Given the letter noted in Science supporting Soffriti's research as well [4], there's no basis for saying that Soffriti's work is largely dismissed by scientists. Sorry, restoring until you can provide better reasons. Removing the large Ramazzini study but then keeping a survey of consumption based on very short-term consumption (1995-1996) and a relationship to cancer is, again, highly questionable -- cancer occurs over long-term exposures. Additionally, you're introducing original research. We can't editorialize that the EFSA used the reasons highlighted by Magnuson, since no sources make that connection. You've also introduced original research by saying that "a small number of scientists" think there's a connection to mental functioning, which isn't in any sources, although I don't have as much of an issue with that. II | (t - c) 22:25, 26 January 2009 (UTC)

I fail to see the justification for featuring so prominently a primary research study by one group, particularly when that one group has been so roundly criticised by far more reliable sources. Perhaps those reliable oversight groups, from the US to the EU to New Zealand, are thoroughly wrong. Nevertheless, they are reliable and should carry more weight on WP than they are accorded here. Inclusion of Ramazzini, which surely represents a scientific fringe, smacks of activism, not encyclopaedia writing. Keepcalmandcarryon (talk) 22:34, 26 January 2009 (UTC)

(edit conflict) @II/Immortale: OK, all well and good, but rats aren't people. Large-scale human studies should probably be given more weight than a rat study, regardless of its statistical power. First of all, the Ramazzini section as written is nearly unreadable. More to the point, we read ten paragraphs about a rat study, and then a few offhand sentences describing huge studies involving hundreds of thousands of humans. That's a canonical violation of WP:WEIGHT ("Note that undue weight can be given in several ways, including, but not limited to, depth of detail, quantity of text, prominence of placement, and juxtaposition of statements.") I'm not saying the Ramazzini study should be excised - it seems to have a notable place on the topic - but its coverage needs to be brought into line with WP:WEIGHT. MastCell ^Talk 22:34, 26 January 2009 (UTC)

I excised the Ramazzini section because of concerns about its encyclopaedic nature (or lack thereof); it had degenerated into an out-of-control back-and-forth. It could certainly stay in the article, but preferably with some of the changes I suggested, all of which were removed by Immortale/II. Keepcalmandcarryon (talk) 22:39, 26 January 2009 (UTC)

"rats aren't people"... That's a good one. I know you haven't made it up yourself because I recognize it from industry propaganda, but according to you we can ban all rat studies and ignore all results, negative or positive, in all scientific research. Scientists use rats because they are very similar to people. I even recognize a few on this page. The cancer study was a poll conducted with people between ages 50 to 69 during 5 years, where they examined only 2 types of cancer with aspartame intake. The details of the results were not published. Dr. Soffriti replied with his expertise that addressed the shortcomings of this poll, despite the large number of participants. But this was removed from the article. Also Adrienne Samuels replied with a letter to the editor about its flaws. To name one: "Estimates of aspartame consumption were based on reports of beverage consumption. Chewing gum, pharmaceuticals, and foods listed by the Aspartame Information Center as containing aspartame were not considered for either supposed aspartame users or non-aspartame users." After all the other severe flaws Samuels stated, the letter ends with: To claim that their findings "are in direct contradiction with [the work of Soffritti et al.]..." is deceptive and misleading.

If any other large independent research of Ramazzini's magnitude doesn't show tumors in rats, it can replace it. Until then it has to stay. Keepcalmandcarryon, read the history, I hadn't removed any of your edits, but I disagree with all of them. George Orwell would be rolling in his grave if he could see how you use Doublespeak and manipulate language to propagandize the safety of aspartame. Immortale (talk) 00:01, 27 January 2009 (UTC)

I'm sorry, I haven't been very active on this page - Immortale, is this the tone you typically adopt here? Do you think it's served you well thus far?

I didn't propose "banning all rat studies" or ignoring their results. I simply suggested that results in humans are more relevant than results in rats. I'm quite familiar with the advantages and limitations of animal models in research. Biological effects in rat models do not always translate into biological effects in humans. If you're faced with a study saying X happens in rats, then it makes sense to test X in humans. But it doesn't make sense to belabor the rat results and marginalize the human results when they don't agree - that's back-asswards at best, and blatant WP:ADVOCACY at worst.

This sort of reminds me of the abortion-breast cancer hypothesis article. Despite numerous large clinical studies showing that abortion does not cause breast cancer, an editor continually insists on prominently featuring and describing the rat study from 1980 which gave rise to the hypothesis. I doubt this is the first time someone's mentioned this, but Wikipedia is not a venue for advocacy. If you honestly feel the need to label anyone favoring human studies over rat studies an "industry propagandist", then consider whether Wikipedia is the best venue for what you hope to accomplish. MastCell ^Talk 00:10, 27 January 2009 (UTC)

If you think that a 2-year survey of aspartame consumption is a reliable indicator for its carcinogenicity of long-term exposure, then I'm afraid I've overestimated your common sense. There's a reason that the 13 scientists who wrote the recent letter to the FDA (PMID 18085058) take the rat results much more seriously than the "human" study. It's not back-asswards. As James Huff (who's been working on cancer since 1980 at the NIH) notes in PMID 18085059, there haven't been any good human studies, and Ramazzini's study was state-of-the art. Huff has more discussion on using animal studies as an indicator for cancer in that paper. For example, he says "3) all known human carcinogens that have been tested adequately in animals are also carcinogenic in the animals,6,8 almost without exception sharing identical target sites6,13; and 4) nearly a third of human carcinogens were first discovered in animals". II | (t - c) 00:39, 27 January 2009 (UTC)

Again, I think this misrepresents my position. I get it: 13 scientists, including James Huff, whose expertise I respect, have concerns about the safety of aspartame. That is notable and belongs in the article. A well-conducted rat study by the Ramazzini Foundation suggested carcinogenic potential - that's notable and belongs in the article. What I object to is prioritizing the rat study over the human studies which have shown no additional risk.

I get it - James Huff doesn't think the human studies were adequate. Perhaps his view should be noted, but to give ten paragraphs to a rat study (even a state-of-the-art rat study), and a few throwaway sentences to large human studies is undue weight, and more basically, it doesn't make sense. I can tell you that in my own field, if I went on at length about elegant rodent studies and minimized the human trials because of their methodologic shortcomings, you'd get a very misleading impression of what we can accomplish.

A minor quibble - you cite Huff to lecture me that "all known human carcinogens that have been tested adequately in animals are also carcinogenic in the animals." Leaving aside the word "adequately", parse that sentence carefully. It does not say that all known animal carcinogens are carcinogenic in humans. That's a subtle but rather relevant distinction. MastCell ^Talk 22:17, 27 January 2009 (UTC)

Rats != humans despite the "13 scientists" and James Huff's agenda-driven points. ScienceApologist (talk) 00:50, 27 January 2009 (UTC)

Oh, right. James Huff (who has spent his entire career studying cancer risks on a researchers' salary), as well all the other NIH and university scientists on that letter, have an "agenda" while the heavily-weighted Magnuson study, financed by Ajinomoto and led by a woman who works for Cantox Internaional, a company which helps clients "facilitate timely regulatory global approval"[5], has no agenda worth mentioning. Coke has even flown Magnuson around to promote aspartame [6]. And yet those who point to special interest lobby are "fringe" and "agenda-driven". I wonder how I could see life through your perspective. This kinda reminds me of those "fringe" Chicken Littles on the economic crisis (Roubini, Krugman, Shiller). II | (t - c) 01:16, 27 January 2009 (UTC)

I don't see evidence that James Huff has any "agenda" beyond advocating what he sees as good science. And I do tend to be suspicious of industry-sponsored research. It's probably best not to go down this road, at least not outside the realm of sourced material on agendas and biases that would be appropriate for the article. MastCell ^Talk 22:21, 27 January 2009 (UTC)

It's worth noting that Magnuson et al. was published in a manner that at showed some deference to concerns of industry bias: The new review was sponsored by aspartame supplier Ajinomoto. However Informa Healthcare took precautions to avoid allegations of underhand influence. It says the panellists were unware who was footing the bill throughout the review process, and up until submission and peer review of the manuscript. Likewise, the sponsor as not made aware of the panelists' identities. "There were no known conflicts of interest with the sponsor or potential biases of the authors," said Informa. This obviously won't convince many people, but for those (like me) who have generalized concerns regarding industry-funded research, it is a step in the right direction. — Scientizzle 01:09, 28 January 2009 (UTC)

Interesting to see Keepcalmandcarryon making 19 edits and deletions in 1 and a half hour, some of them within one minute, while some editors here worked on it for weeks. Equally interesting, is that all serious edits and deletions were done in parts that were critical towards aspartame. And then you wonder why less and less people take Wikipedia serious these days. MastCell, I rather see good scientific research on rats than a flawed poll on humans. And don't forget the 7 monkeys in the Olney study, presented by Searle, where 2 died and 5 received grand malseizures. Immortale (talk) 21:45, 27 January 2009 (UTC)

As I mentioned above, mouse studies tend to be more "elegant" and methodologically impressive than human studies. That's because you can put a rat in a cage, feed it exactly what you want, and then sacrifice it for necropsy. Most humans aren't quite as pliable, so human studies will always look "flawed" from that perspective. Still, it would be a great mistake to dismiss "flawed" human studies in favor of "good" rat studies. The reason is that not all biological effects in a rodent model translate into biological effects in humans.

I see we've gone from a few hundred rats to 7 monkeys. All I'm saying is that maybe, just maybe, we should give as much space to studies involving 12,000 or 460,000 humans. Does that make me an industry propagandist? MastCell ^Talk 22:31, 27 January 2009 (UTC)

Immortale, I visited this article after a query was placed on the reliable sources noticeboard about a source being used here. The manner in which the query was worded raised some flags for me. After looking through the article, I felt that a strong emphasis was being placed on selectively interpreted primary sources. In the case of some of the sources I ended up removing, the claims being made did not square at all with the contents of those sources. If you perceive my edits, which have mainly insisted on reliable sources and proper weight, as being slanted, perhaps this perception is instructive of your own point of view. My own opinions on aspartame are largely restricted to my intense dislike of its taste. Keepcalmandcarryon (talk) 22:58, 27 January 2009 (UTC)

Mastcell, the Cancer study is flawed not because "Most humans aren't quite as pliable" but to use the letter by Adrienne Samuels about this study:

Aspartame Consumption and Incidence of Hematopoietic and Brain Cancers Adrienne Samuels <snip> Then it doesn't matter if there were 12 000 or 12 million people involved. It doesn't prove anything. Immortale (talk) 23:49, 27 January 2009 (UTC)

This is kinda what I'm talking about with regard to undue weight and WP:ADVOCACY. You cite a critical letter to the editor. Did you look at the authors' response to the criticisms? It was published on the immediately following page. The authors performed a number of the analyses that Samuels demanded, none of which showed evidence of harm from aspartame. It seems a bit one-sided to produce a letter-to-the-editor to show that the study "doesn't prove anything", without mentioning that the authors addressed many of the criticisms on the very next page of the journal. MastCell ^Talk 00:33, 28 January 2009 (UTC)

Adrienne Samuels is hardly some impartial researcher working in the field...her doctorate is in experimental psychology, and her entire PubMed body of work appear to be various letters-to-the-editor--like the one above--that support her general activity as an anti-MSG activist. This doesn't make her wrong, of course. However, it does temper any suggestion that her opinions are of sufficient note to warrant coverage in this article. — Scientizzle 01:28, 28 January 2009 (UTC)

I appreciate your responses MC, but really, the authors are still way of line speculating that their study is "in direct contradiction with Soffriti's". The argument isn't whether consuming aspartame for a few years, even in large amounts, substantially increases the risk of cancer. The authors cite some evidence for consistent dietary patterns, but considering that the consumption of aspartame-sweetened soft drinks has exploded in recent years, it's not really convincing. Consumption of aspartame would likely increase with age as diabetes and weight become more of a problem. When aspartame was approved in 1981 (not for use in soft drinks), these people were at least 22. Anyway, I'm surprised that you're so impressed by the study, which is pretty disappointing science. II | (t - c) 01:20, 28 January 2009 (UTC)

I agree it's not in direct contradiction to Soffriti's. It's entirely possible that both are correct - that aspartame as administered by Soffriti et al to rats causes cancer, while aspartame as consumed by the respondents to the survey does not. It's possible that the study doesn't reflect current consumption patterns. On the other hand, these appear to be the best available human data. Better and more recent data would be nice, but Wikipedia isn't the place to demand it, really. We're kinda stuck with what's available here. MastCell ^Talk 05:37, 28 January 2009 (UTC)

I think the section should be deleted. It really is too long per WP:WEIGHT. Frankly, all of the studies can be summed up in a couple of paragraphs. OrangeMarlin ^{Talk• Contributions} 00:55, 28 January 2009 (UTC)

At the acceptable risk of being thought to mimic MastCell, it is possible that both studies are correct. A major difference between the two for WP purposes is not, as II seems to assume, whether I or MastCell or Immortale agree or disagree with the results or the conclusions of one or the other, but rather the demonstrable fact that multiple national agencies and numerous individual scientists have published studies and statements rebutting the Ramazzini study. Yes, the NCI study has its drawbacks, as MastCell and II have shown. But it has not been the subject of a similar level of worldwide criticism by experts. On WP, the conclusions of scientists forming a national regulatory body are to be given more weight than the conclusions of a single laboratory. And all the more so when multiple such agencies come to the same conclusions.

Of course, we can synthesise the conclusion that all of these national bodies, along with many individual scientists, have been subverted[7] by industry bribes or threats. Without reliable sources to support this claim, though, it has no place on WP.

The weight problems in this article and the ongoing debate demonstrate why we, as editors, are discouraged from evaluating primary research studies on our own when writing the encyclopaedia. Let's make a renewed effort to follow WP:RS, and specifically its suggestions on primary and secondary sources. Keepcalmandcarryon (talk) 18:01, 28 January 2009 (UTC)

Keepcalmandcarryon uses as argument "the conclusions of a single laboratory", but he deleted a couple of references I added to articles more recent than the Science article, with the reason "Don't need these; the additional references are those covered by the Science news item, which is more easily accessed and fairly reliable". That article was published in July 2007, one month before the publishing of the second study by Ramazzini Institute (August 2007). The online unavailability of the articles i cited there (Aspartame and Incidence of Brain Malignancies in Cancer Epidemiol Biomarkers Prev Davis et al. 17 (5): 1295 and James Huff, Joseph Ladou. (2007). Aspartame Bioassay Findings Portend Human Cancer Hazards. International Journal of Occupational and Environmental Health, 13(4), 446-8. Retrieved February 25, 2009, from ProQuest Medical Library database. (Document ID: 1386523321)) can't be a reason to ignore those: they're available to the scientific community. The Calcutta University study i cited down here, in a specific section, confirms the risks, so I believe that the situation is changed. The national regulatory bodies should have more weight in the discussion if they only made some comments about these studies, but i can't find a single comment from them since July 2007. (Karloff (talk) 13:35, 26 February 2009 (UTC))

Synthesis and failed verification

I removed a sentence from the aspartame byproducts section. Four primary sources were used to synthesise a claim that aspartame intake is dangerous to infants or children because methanol potentiates the effects of excitoxins. As far as I can tell, the first, second, and fourth sources are about glutamate, while the third source is about chronic methanol consumption in rats. These sources do not support the claim, so I have removed it. My detailed reasoning follows.

"One group was concerned with potential effects in infants and young children"...citing an essay by researcher JW Olney from 1990. "small-to-moderate spikes on plasma excitotoxin levels" again citing an Olney paper, this one from 1994. I do not have access to the full text of these dated pubs, but they seem to be about glutamate receptors, and I'm not sure how relevant they are here, nor how much weight we should be giving to this one researcher's work. In any case, the rest of the paragraph is pure synthesis:

"the potential dangers of combining formaldehyde exposure from aspartame with excitotoxins given that chronic methanol exposure increases excitoxin levels in susceptible areas of the brain"

• The first citation is a study of rats that receive 2g/kg/day of methanol. Since methanol comprises 10% of the breakdown products of aspartame, this is roughly comparable to 20g/kg/day of aspartame, assuming that all of the aspartame is broken down: 500 times higher than the ADI established by world health authorities. You would have to drink about 10 000 cans of diet soda in a day to get this sort of intake. The authors cite a monkey study in which methanol exposure does not cause pathology. The study does not mention aspartame and is being used here to synthesise a conclusion.
• The second citation is a study of rat retinal segments exposed to 1 millimolar glutamate in the presence or absence of various glutamate transporter inhibitors. Glutamate, while similar in properties to aspartate, is not the same thing. The study mentions neither methanol nor aspartame. It seems to have in common with some of the other studies cited here only an author, JW Olney, and it really has nothing directly to do with the topic of this article. Keepcalmandcarryon (talk) 19:13, 28 January 2009 (UTC)

Tag removal

The deletion discussion [8] included recommendations that fringe science be trimmed, through bold edits if necessary. I feel that recent edits, including mine, have achieved this goal or at least moved the article towards appropriate balance. I propose that the POV tag be removed. An article on a controversial topic such as this will never be completely acceptable to the conspiratorial-minded and other editors who espouse fringe viewpoints; this is however not a valid reason for maintaining a POV tag. Keepcalmandcarryon (talk) 17:23, 29 January 2009 (UTC)

Verrett, Gross, and Bressler

The last edit removed a couple sources on Verrett and Gross's testimony. My impression is that Verrett and Gross were senior toxicologists (Verrett certainly was a toxicologist for the FDA, likely, as she says, from 1957-1977 -- see her testimony hosted on a USDA website) on the task force reviewing 3 of the 15 studies noted in the article, which I believe was headed by another FDA scientist, Jerome Bressler. Generally the burden is on the remover of a source to show that it doesn't support its claims. However, there's a problem (according to Keepcalm - I haven't been able to double-check) with failed verifications on this article, so we can keep this out until someone verifies it directly. These sources can likely be found in the Congressional Record with the provided information or, for the book, through an ILL from WorldCat. Copies, which are almost certainly but not positively genuine, are on the internet [9]. Basically these two people say that management ignored the scientists (Gross, Verrett, and Bressler) and created a whitewash summary when they said the errors were inconsequential. These FDA scientists are an important, notable part of the conspiracy theory and at some point will need to be noted in the article. II | (t - c) 18:54, 29 January 2009 (UTC)

I have no objections to including the two former FDA officials' testimony in the relevant section. I object only to placing their stated opinions on equal footing with the FDA's organisational conclusions in the lead--whether those official conclusions are part of the approvals and reviews or summarised (on the FDA's website) in the FDA's publication as cited. Without secondary sources reviewing their testimony, we don't know if these officials' objections were significant, whether they were simply disgruntled former employees, or anything else.

With multiple national and international scientific and regulatory bodies, including the FDA, stating that aspartame is safe, even after (and in detailed and careful response to) the release of the Ramazzini studies, it's a gross violation of WP:UNDUE to place these primaries in the lead. Keepcalmandcarryon (talk) 19:15, 29 January 2009 (UTC)

I certainly agree about putting them in the lead. And there isn't as much secondary coverage as one would think aside from WNHO et al. The Ecologist ran an article on it [10], and Davis covers it in her book [11]. II | (t - c) 19:35, 29 January 2009 (UTC)

FDA Consumer

Re: the most recent edit-war over citation of FDA Consumer in the lead: it seems to me that FDA Consumer is a reliable source for describing the conclusions of FDA's scientists - after all, it is a journal published and presumably vetted by the agency. It seems tortuously legalistic to write: "The FDA's magazine reported that the FDA's scientists said that..." I agree with II that the date (1999) should be mentioned as important context. Just write "In 1999, FDA scientists described aspartame as..." and source to FDA Consumer. That seems pretty straightforward. MastCell ^Talk 19:19, 29 January 2009 (UTC)

Indeed. That's completely fine; it's too bad I didn't think of it. II | (t - c) 19:29, 29 January 2009 (UTC)

Agreed. The relevant passage from the publication is:

...the safety of another artificial sweetener, aspartame, is clear cut, say FDA officials. FDA calls aspartame, sold under trade names such as NutraSweet and Equal, one of the most thoroughly tested and studied food additives the agency has ever approved. The agency says the more than 100 toxicological and clinical studies it has reviewed confirm that aspartame is safe for the general population.

Clearly, these are not simply the opinions of Jon Henkel, and, particularly as they appear on the FDA website in its own publication without disclaimer, are reasonable representations of the FDA position. The FDA's stance also has not changed since 1999, at least according to statements from the FDA as recently as 2006 in response to the Ramazzini studies...which the FDA promised to examine more closely, while noting that its own research did not indicate problems. Keepcalmandcarryon (talk) 19:31, 29 January 2009 (UTC)

We don't know whether the FDA officials would be so bold as to say its safety is so clear-cut today, after the Ramazzini studies. To cite that Henkel's article as "The FDA states" is misleading. They did recently dismiss the Ramazzini studies in a press release, but they didn't release a detailed report (the detailed report came from the EFSA). Henkel's reporting reflects his research, and it's not quite the same as an official statement from the FDA, so I think it's misleading to say attribute his article as an official FDA statement. What I just added was an official FDA statement. II | (t - c) 19:49, 29 January 2009 (UTC)

We actually probably do know. FDA could not conduct a complete and definitive review of the study because ERF did not provide the full study data. Based on the available data, however, we have identified significant shortcomings in the design, conduct, reporting, and interpretation of this study. FDA finds that the reliability and interpretation of the study outcome is compromised by these shortcomings and uncontrolled variables, such as the presence of infection in the test animals. Additionally, the data that were provided to FDA do not appear to support the aspartame-related findings reported by ERF. Based on our review, pathological changes were incidental and appeared spontaneously in the study animals, and none of the histopathological changes reported appear to be related to treatment with aspartame. FDA believes that additional insight on the study findings could be provided by an internationally-sponsored pathology working group examination of appropriate tissue slides from the study. Considering results from the large number of studies on aspartame's safety, including five previously conducted negative chronic carcinogenicity studies, a recently reported large epidemiology study with negative associations between the use of aspartame and the occurrence of tumors, and negative findings from a series of three transgenic mouse assays, FDA finds no reason to alter its previous conclusion that aspartame is safe as a general purpose sweetener in food. "Aspartame is safe as a general purpose sweetener in food" is a distinctly unequivocal statement... — Scientizzle 23:45, 29 January 2009 (UTC)

Regarding the Henkel article, it states:

...the safety of another artificial sweetener, aspartame, is clear cut, say FDA officials. FDA calls aspartame, sold under trade names such as NutraSweet and Equal, one of the most thoroughly tested and studied food additives the agency has ever approved. The agency says the more than 100 toxicological and clinical studies it has reviewed confirm that aspartame is safe for the general population"

This clearly indicates that FDA officials and FDA are of the opinion that aspartame's safety is "clear cut" and "one of the most thoroughly tested and studied food additives the agency has ever approved", respectively. We can properly assert this in the article--adding the date of publication is entirely reasonable. I don't know what is so controversial about this... — Scientizzle 23:45, 29 January 2009 (UTC)

"FDA Consumer: Published online between 1989 and 2007". That's quite impressive to publish such a journal online before modern internet came to existence. John Henkel signs his article as "John Henkel is a staff writer for FDA Consumer." Not as a spokes person for FDA. So that's WP:OR. Then Henkel writes this: "In 1996, a study raised the issue that aspartame consumption may be related to an increase in brain tumors following FDA's approval of the sweetener in 1981. But analysis of the National Cancer Institute's database on cancer incidence showed that cases of brain cancers began increasing in 1973--well before aspartame was approved--and continued to increase through 1985. In recent years, brain tumor frequency has actually decreased slightly." Now comes the interesting part, in another issue of FDA Consumer, Evelyn Zamula comes to an opposite conclusion: "...In the United States, about 100,000 cases of brain tumors are predicted for 1996, almost double the number of just a decade ago..." "... The incidence of brain tumors, both primary and metastatic, appears to be increasing worldwide, especially among the elderly, and no one is sure why..." There are many other studies done during those particular years that show a rise in cancer, such as:

In 1999, the National Cancer Institute looked at the trends in childhood cancer between 1975 and 1995. They found a "statistically significant" rise in the occurrence for brain and other central nervous system cancers. They wrote: "For brain and other central nervous system cancers, incidence rose modestly, although statistically significantly…" —Linet MS, Ries LA, Smith MA, Tarone RE, Devesa SS, "Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States" J Natl Cancer Inst 1999 Jun 16;91(12):1051-8

That same year, the International Journal of Health Services published a report in which they stated that the "rising childhood cancer rate represents a far more serious problem in the United States than previous reports have suggested." "From the early 1980s to the early 1990s, the incidence of cancer in American children under 10 years of age rose 37 percent, or 3 percent annually. There is an inverse correlation between increases in cancer rates and age at diagnosis; the largest rise (54 percent) occurred in children diagnosed before their first birthday. Rates rose for all 11 states and cities included in the analysis. A jump in cancer rates for children born in 1982-83 was followed by a drop; but another abrupt rise for the 1986-87 birth cohort has been sustained thereafter. Results indicate that the rising childhood cancer rate represents a far more serious problem in the United States than previous reports have suggested…" —Mangano JJ, "A rise in the incidence of childhood cancer in the United States" Int J Health Serv 1999;29(2):393-408

The FDA is corrupt and recently a group of federal scientists complained to the Obama transition team of widespread managerial misconduct in a division of the Food and Drug Administration. Immortale (talk) 21:22, 29 January 2009 (UTC)

I got as far as your first citation of policy (WP:OR), which struck me as completely off-base. FDA Consumer is an official magazine of the FDA, and hence for all intents and purposes is on the same footing as a spokesperson's words. We're not citing FDA Consumer to document the incidence of brain tumors. The literature you mentioned would be a better source for those numbers. We're simply citing FDA Consumer as accurately conveying the conclusions of that agency's scientists.

Playing "Kick the FDA" is a popular Wikipedia (and national) pastime, and in some respects justifiable, but it has no bearing on this particular content issue. You probably realize this, since you carefully worded your final sentence to minimize the fact that the criticism dealt with regulation of medical devices, not foodstuffs. MastCell ^Talk 22:54, 29 January 2009 (UTC)

Sadly, I read the whole screed. I haven't the desire to go dig up actual numbers, but it's easy to see Immortale's claims, while presented as refutation of the maligned FDA Consumer assertion, have at-best tangental bearing.

• FDA Consumer claim: brain cancer incidence began increasing in 1973 (before aspartame was approved) and continued to increase through 1985; aspartame was targeted as a possible reason, but brain tumor frequency decreased slightly between that assertion and the 1999 publication.
• The second article claims an increasing worldwide incidence; this seems perfectly congruent with the first claim--brain tumor incidnece had climbed over the course of a decade, perhaps leveling off in the last years of said decade.
• A rise in childhood cancers, modest (CNS) or surprising (overall), is a separate beast that doesn't appear to counter anything claimed in the first point. I doubt the largest rise, ≤1 year, has much practical relation with aspartame.
• Whether the FDA scientist letter leads to anything concrete will be an interesting and important thing to watch; the confidence working-level FDA scientists and medical experts is very important to me. However, its relevance to a decade-old claim or the 34-year-old aspartame approval is unclear (beyond poisoning the well).

Also, I can't help but note that dismissing some FDA claims, because they apparently don't suit your position(s), and accepting others, because they apparently do, seems a touch...disingenuous. — Scientizzle 23:26, 29 January 2009 (UTC)

Recent changes to lead

The conclusions in the cited article, First Experimental Demonstration of the Multipotential Carcinogenic Effects ... do support the statement that

 a small number of scientists hypothesize that aspartame could ... cause some forms of cancer

and not only in rats. Sofritti et al. concluded that aspartame had caused the treated rats to get more cancers than the control population, but also said

The results of carcinogenicity bioassays in rodents are consistent predictors of  human 
cancer risks (Huff 1999; Rall 1995; Tomatis et al. 1989). The results of  our study 
therefore call for an urgent reexamination of the present guidelines on the 
use and consumption of APM.  

The citation supports the statement that the authors hypothesize that aspartame could cause cancer in humans, (in addition to supporting the unstated assertion that the authors concluded that aspartame causes cancer in rats). Therefore, I have removed the phrase "in rats" from that sentence, which is now as User:Immortale last left it.

Of course, if the researchers were hypothesizing that aspartame might cause cancer only in rats but not in humans, the entire phrase "or cause some forms of cancer in rats." ought to have been left out as irrelevant to a presentation of the controversy over aspartames affects on the health of humans (the topic of this article).

Since every word of this article has become contentious, I feel it might be necessary to give a very careful explanation of the meaning of each rewording, as well as justification for the support of appropriate references. This My edit of this sentence does not mean that I either support or challenge the cited Sofritti study, merely that I wish this article to convey its the study's significance to the ongoing debate. --SV Resolution(Talk) 19:06, 30 January 2009 (UTC)

I disagree with your recommended changes. OrangeMarlin ^{Talk• Contributions} 19:17, 30 January 2009 (UTC)

I think it is useful to hash these things out. Please be as specific as possible on why you disagree with the deletion of the words "in rats" at the end of the first paragraph of the lead. --SV Resolution(Talk) 19:21, 30 January 2009 (UTC)

It is in rats. It's NOR to conclude that a rat model can be translated to humans. It is one study, that I would consider deficient in so many ways, one of which is that numerous other studies don't come the conclusions it did. In fact, I'd delete both sentences as violating WP:WEIGHT. This has been discussed and decided many times. Why do we have to converse about it again.OrangeMarlin ^{Talk• Contributions} 19:25, 30 January 2009 (UTC)

If there weren't controversial, it wouldn't be in aspartame controversy. I'm certain the lead needs some major rearranging. I think it is fair to say that the aspartame controversy was FIRST about claims that the route to FDA approval was irregular, and that there were some unanswered questions about the Searle studies, SECOND about the contents of the Betty Martini letter and its Nancy Markle offspring (with references to Roberts and ???), and THIRD about the recent Ramazzini studies and rebuttles.

I may be pruning branches while the orchard is burning, and there may be some questions about undue weight, but if we aren't going to delete the entire sentence, "in rats" should go. It misrepresents the position of a minority party in the controversy. --SV Resolution(Talk) 19:48, 30 January 2009 (UTC)

Part of the problem is too much reliance on primary sources. We should avoid synthesizing journal articles into a thesis that nobody has made in a reliable secondary source. Tom Harrison ^Talk 20:10, 30 January 2009 (UTC)

Tom, You're right. I prefer primary sources. But even I know that's not always best. Newspapers, "Sweet Poison", snopes(?)

Now, to attend to the forest instead of the branchlets on the trees. I'm not bold enough to replace the lead without discussion, so here's a go at it, in my own namespace: draft of new lead section --SV Resolution(Talk) 21:54, 30 January 2009 (UTC)

I have reverted this edit by Orangemarlin, which in my opinion can only be explained with bad faith, absent-mindedness or lack of reading comprehension after this clear explanation of the problem by SV Resolution. Sorry for the language. I have no opinion about this controversy, the quality of the study, or whether it should be included here. But misrepresenting sources is never acceptable and I remind everybody here (just in case others on either side are similarly negligent, this article being new on my watchlist) to show some diligence not to do it. --Hans Adler (talk) 12:22, 31 January 2009 (UTC)

I agree with Tom's removal of the contentious material from the lead, allowing the article to present the much-criticised study in proper context in a later section. Keepcalmandcarryon (talk) 19:22, 31 January 2009 (UTC)

methanol to formaldehyde...or formate?

There seems to be some confusion about whether methanol metabolism proceeds as methanol-formaldehyde-formic acid or MeOH-formate-formaldehyde. The former is correct. See this overview for a simple description. Keepcalmandcarryon (talk) 23:32, 2 February 2009 (UTC)

Activists?

In the section "Approval in the United States" it says: "Soon after the approval, scientist and anti-MSG activist John Olney and James Turner, a public-interest lawyer who had written a popular anti-food additive book". I suggest we label the scientists who have made pro statements as "pro aspartame activists". Labeling a scientist as an activist is POV because I'm sure it's not mentioned on his job description. That Turner wrote the book "A Chemical Feast", a critical evaluation of certain food additives, and then calling it an anti-food additive book is also a POV statement. If I would start calling those who wrote pro aspartame articles as "pro food additive articles" then no one would hesitate to remove such edits. And I'm sure it would be tagged as POV. There are many more double standards in the article, but this is what I just spotted. Immortale (talk) 11:11, 14 February 2009 (UTC)

This comment is highly spun and not a true representation of the facts. Scientists with a clear bias should be labelled as it is relevant information, scientists who have campaigned or opined on related topics outside of their research should be so labelled. Labelling scientists who have simply conducted research and published their findings as pro or anti is not fine. The difference is "scientist and activist" and "scientist". Verbal chat 11:57, 14 February 2009 (UTC)

How are people with 'activist' tendencies appropriately labeled? Based on the nature of their talks? Based on their extroverted personality types? Are they just speaking about their results too much, and not helping others replicate their experimental results? Do they use ad-hominem attacks? After all, stastitics have shown that 20% of activists were actually justified in their activism, because they were right after all :-) Foodfan (talk) 13:21, 14 February 2009 (UTC)

Verbal, when you write: "Scientists with a clear bias should be labelled as it is relevant information, scientists who have campaigned or opined on related topics outside of their research should be so labelled." So when B. A. Magnuson gets big bucks from Ajinomoto to compile a review of an amount of studies, then go on a world-wide tour paid by Coca-Cola, to promote the safety of aspartame, she is not considered bias? Either you apply your rules on all scientists, or none at all. Immortale (talk) 18:23, 14 February 2009 (UTC)

Olney and Turner are both activists in addition to being, respectively, a scientist and a lawyer. This isn't an attack on either, merely a relevant fact. When a scientist campaigns against a particular food additive in the popular press and by lobbying the government as a private citizen, he has become an activist. It's not uncommon in science, nor unwelcome, for scientists to feel so strongly about their research findings--or their interpretation of their research findings--that they become active outside the normal bounds of scientific discourse. This is quite clearly the case for Olney, as demonstrated by the sources in the article. On the other hand, your accusation against Magnusson is one of impropriety: namely, that Magnusson accepted bribes to come to a pre-determined conclusion, subverting scientific ethics. Without reliable sources for this defamatory comment, you are venturing onto thin ice, in terms of both WP:NOR and WP:BLP. Keepcalmandcarryon (talk) 19:00, 14 February 2009 (UTC)

I'm not talking about bribes, I'm talking about a fat salary that Ajinomoto paid consultant Bernadene Magnuson with The Burdock Group (Burdock's slogan: "To find out more about how we can help bring your product to market quickly and effectively, contact Burdock Group today for a complimentary consultation." See: http://en.wikipedia.org/wiki/Talk:Aspartame_controversy/Archive_1#Industrial%20sponsored%20research). These are not well-kept secrets, and sourced in respected peer-reviewed journals and we have discussed this before to include its sponsor in the article. That her publicity tour was paid by Coca-Cola was no secret either. She even admitted it while being on New Zealand television: http://tvnz.co.nz/view/video_popup_windows_skin/2096071 Immortale (talk) 19:48, 14 February 2009 (UTC)

I concur with Keepcalmandcarryon. Your continued smear, without any evidence, is not helping your case and is pushing the limits you have already been made aware (warned) of. Verbal chat 19:53, 14 February 2009 (UTC)

Am I the only one who reads here? I cited hard evidence. But your association with "smear" indicates that you disapprove of such tactics as Magnuson has exercised. And I take your warnings with a grain of salt, coming from someone who has cited references with opposite conclusions. Immortale (talk) 00:19, 15 February 2009 (UTC)

"The authors received payment from the Burdock Group during the preparation of an expert review of the safety of aspartame. The Burdock Group managed the independent review, which was financially supported by Ajinomoto Company Inc., a producer of aspartame." (from Magnuson & Williams' Carcinogenicity of Aspartame in Rats Not Proven in Environ Health Perspect. 2008 June; 116(6): A239–A240) (Karloff (talk) 13:53, 26 February 2009 (UTC))

Aspartame and consumer associations

My last edit has been reverted because of a non-neutral-view reason. I just added references to the fact that FDA has not yet considered the last Ramazzini study, nor the European Authority has done it officially in Internet available notices. Another information I added is that not only "internet conspiracy theories", but also some consumer associations (i omitted the italian ones, like http://www.inran.it/, as cited in one of the main italian consumer magazines, "il Salvagente", 21-28 june 2007) did published warnings about aspartame. These are facts, and i cited sources about it, that's not my point of view, but the official position of noted organizations. I don't think wikipedia should argue about their specific "political" point of view, but just provide facts from "all significant views that have been published by reliable sources" (NPOV). I also tried to correct the confusion about the discussion of the articles published by Ramazzini, because the section is referred (with so much detail!) only to the reactions to the first study, and nothing there is related to the second study. (Karloff (talk) 21:12, 25 February 2009 (UTC))

Hi, i just tried to explain the reasons of my edit to the Ramazzini section in the Aspartame controversy page. I think that what's happening now in the dispute about aspartame should be actualized, considering both the reactions of the market to the study and the reaction of Consumer Organizations, not only the scientific reviews, leaving to the reader the decision about being favorable or not.

That is what is in discussion now on some important newspapers about aspartame, and i cited the relative references.

Moreover, the last available study on aspartame make some claims, and it has been published in september 2007. From a scientific perspective i think the whole section has a non neutral POV: the claims reported are a mix of considerations about the first and the second study, and only one of the cited articles has been published after the publishing of the second study: that one has been answered by Soffritti in the cited reference(not shown in the html version of the article, but in the pdf version), and clearly states that the authors (Magnusson & Williams) received financial support by an aspartame producer. (Karloff (talk) 09:54, 25 February 2009 (UTC))

Moved from my talk page--I do not discuss articles on my user talk page. Moreover, I have no clue what you're saying. OrangeMarlin ^{Talk• Contributions} 15:37, 25 February 2009 (UTC)

Does it mean I can undo the deletion? I'm just trying to understand why my edits were considered not neutral.(Karloff (talk) 22:43, 25 February 2009 (UTC))

Dear Orangemarlin, here we are asking in detail the reason for such edit. As simple as that. Can we undo the rollback? If not why? --Biopresto (talk) 15:21, 26 February 2009 (UTC)

The Science news item is a prominent secondary source for the statement that some individuals supported the study's conclusions. It is easily accessible. It mentions the letter to the FDA by Huff and others. I simply don't see the justification (see WP:WEIGHT) for adding additional sources to this statement, especially when they are less reliable, obscure primary sources. Keepcalmandcarryon (talk) 15:50, 26 February 2009 (UTC)

I'm talking about a study published in August 2007 and the reactions to it, you're talking about an article published in july 2007. How is it possible, in your opinion, to consider it a collection of conclusions about that article? Why remove the information about the warnings officially published by a consumer association instead of discussing here about the deletion? I can't understand why an Encyclopedia should remove informations about the only public information published after some magic date, stating that somewhere in a cited source in some note everyone can find the hidden information (NPOV:Space and balance:Information suppression) (Karloff (talk) 16:55, 26 February 2009 (UTC))

The Ramazzini group published two papers on their first study in 2006. They published a paper on a second study in 2007. This paper was published online in June of 2007, then in print in September of 2007. The Science news item about James Huff and other scientists who expressed concern based upon the Ramazzini studies was published in August of 2007. This follows the on-line publication about the second study. In addition, specialists are often aware of the conclusions of upcoming publications before they are published (as a result of personal communication, conference attendance, etc.). There's no date contradiction here.

When we have a reliable source for information, there's no need to add additional, less reliable, lower-impact, less easily-accessible sources unless we have a good reason for doing so. In this case, I don't see what that reason would be, other than perhaps to advance a viewpoint beyond the weight it commands in the literature. Keepcalmandcarryon (talk) 19:33, 26 February 2009 (UTC)

Sorry it was my fault, i didn't double check the dates (and contents). What to do about the unanswered claims of consumer associations and their advices? What's puzzling me then is why to list the Magnuson and William's letter reasons and not the answers given by Soffritti et al. 2008 or the letter by Davis et al. 2008. These are my two unanswered questions now. (Karloff (talk) 00:11, 27 February 2009 (UTC))

Again, WP:WEIGHT. Yes, there are people who think aspartame is a genocidal conspiracy. Yes, there are some scientists who feel it may pose a health risk. So far, the balance of the scientific evidence does not seem to support these concerns, so the article should not be a repository of all references (letters and articles in journals, consumer websites, etc.) that oppose aspartame. We should cover the controversy, give some representative references and avoid giving undue weight to the minority position. It appears to me the article does this. Keepcalmandcarryon (talk) 00:56, 27 February 2009 (UTC)

University of Calcutta

Anyone has access to the full text of Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin, Bandyopadhyay A, Ghoshal S, Mukherjee A. Drug Chem Toxicol. 2008;31(4):447-57? In the abstract they affirm a potential health risk. (Karloff (talk) 22:43, 25 February 2009 (UTC))

See WP:WEIGHT. Thanks. OrangeMarlin ^{Talk• Contributions} 19:37, 26 February 2009 (UTC)

It says "Neutrality requires that the article should fairly represent all significant viewpoints that have been published by a reliable source, and should do so in proportion to the prominence of each." The NPOV adds: "Neutral point of view is a fundamental Wikimedia principle and a cornerstone of Wikipedia. All Wikipedia articles and other encyclopedic content must be written from a neutral point of view, representing fairly, and as far as possible without bias, all significant views that have been published by reliable sources". Maybe in your opinion the review Drug Chem Toxicol. is not a reliable source (see [12])? Reliable doesn't mean accessible online by everyone, isn't it? Anyone has access to the printed version of that article or to the online versione to write here, in the discussion page, and maybe in the aspartame controversy page, a resume of it? (Karloff (talk) 00:21, 27 February 2009 (UTC))

Are you asking for a copy of the article? It's copyrighted, and available by subscription only. Are you proposing that it be used as a source for some claim? If so, what? Keepcalmandcarryon (talk) 00:58, 27 February 2009 (UTC)

I just asked for a resume, not for the article. I've just found new information and i would like some informed people could add something instead of adding it myself. It seems there are some experts in toxicology here, so i asked for a contribution. Is it strange? The article abstract is a reliable source or not? Has it been added to the aspartame article before? Do you think we should wait for a secondary source before writing anything in wikipedia? (Karloff (talk) 18:52, 27 February 2009 (UTC))

All significant views do not include fringe views. If 10,000 articles say aspartame is safe, and one implies something different (and in a non-human model), then we're not going to discuss it. If you can find several researchers across the world, all repeating the same results, then we can have that discussion. Right now, this is a fringe theory. OrangeMarlin ^{Talk• Contributions} 19:03, 27 February 2009 (UTC)

Waiting for a secondary source is preferable to interpreting primary findings, particularly when one doesn't have access to the primary findings. Keepcalmandcarryon (talk) 20:23, 27 February 2009 (UTC)

Ok, keep on deleting every primary source, following the WP:WEIGHT. My citation of an EPA revised study has been totally deleted by Keepcalmandcarryon (because the use of the term "confuted" 'was a bit strong' for an article proving that the claim of FDA and Magnuson was not based on scientific data) in the same line citing the last Magnuson article "Carcinogenicity of Aspartame in Rats Not Proven". That is not a revised article, just a letter, and it has received no citations in scientific revised studies. It's just the opinion of a scientist in COI. Peer-reviewed articles ARE NOT PRIMARY SOURCES! So please stop deleting important sources showing what's really thinking the scientific community! Is it really impossible to discuss such facts here? Hiding sources means ignoring what are the Wikipedia policies:
- "In general, the most reliable sources are peer-reviewed journals and books published in university presses" [WP:SOURCES]
- i can't understand why Orangemarlin is talking about fringe theories, but "A fringe theory can be considered notable if it has been referenced extensively, and in a serious manner, in at least one major publication, or by a notable group or individual that is independent of the theory." [WP:FRINGE]
- "Do not leave unsourced or poorly sourced information that may damage the reputation of living persons or organizations in articles". In the list following "Reviews of the Ramazzini claims found numerous problems with the study" to ignore such an important study as that made by EPA (there are others, check google scholar) is a clear attack to its scientific reliability WP:SOURCES
- to increase NPOV of this page, "Wikipedia articles should cover all major and significant-minority views that have been published by reliable sources." WP:RELIABLE
- "Material that has been vetted by the scholarly community is regarded as reliable; this means published in reputable peer-reviewed sources and/or by well-regarded academic presses." WP:RELIABLE
all these policies are ihmo for inclusion of J. C. Caldwell, J. Jinot, D. DeVoney, J. S. Gift, [Evaluation of evidence for infection as a mode of action for induction of rat lymphoma], Environmental and Molecular Mutagenesis, Volume 49 Issue 2, Pages 155 - 164, Published Online: 19 Dec 2007, and for the removal of Magnuson 2008 (Carcinogenicity of Aspartame in Rats Not Proven) (Karloff (talk) 21:36, 28 February 2009 (UTC))

Again. WP:WEIGHT. OrangeMarlin ^{Talk• Contributions} 01:43, 1 March 2009 (UTC)

I support Orangemarlin's trimming of the Ramazzini section, which was clearly getting out of proportion and becoming a POV coatrack.

On "Peer-reviewed articles ARE NOT PRIMARY SOURCES! So please stop deleting important sources showing what's really thinking the scientific community! Is it really impossible to discuss such facts here?": Peer-reviewed articles are indeed primary sources unless they are reviews, i.e. secondary sources. Wikipedia is not a debating society; that's what the primary literature is for. The Ramazzini studies became notable via coverage in secondary sources; response from the mainstream scientific community is warranted under WEIGHT; further back-and-forth using very low-impact journals is not. Keepcalmandcarryon (talk) 21:06, 1 March 2009 (UTC)

Sweet Misery - A Poisoned World

Can someone explain to me why http://video.google.com/videoplay?docid=-566922170441334340 is not suitable as a related link?

Because of WP:NPOV. In other words, it's cruft, not befitting an encyclpedia. OrangeMarlin ^{Talk• Contributions} 06:51, 8 March 2009 (UTC)

Correct me if I am wrong, but isn't this an entry on "Aspartame controversy" ? as such shouldn't references and sources that pertain to that 'controversy' be admitted? No one is saying that everything in the documentary is true, merely that it exists and is relevant to the entry "Aspartame controversy". For you to say that it is 'cruft' smacks of original research. I am going to put the reference in the article as it *is* indeed relevant to "Aspartame controversy". 125.26.244.225 (talk) 07:46, 8 March 2009 (UTC)

I agree that the link to a professional documentary that is about the ASPARTAME CONTROVERSY belongs in an article about the ASPARTAME CONTROVERSY. Besides that, the documentary contains interviews with a variety of people who are mentioned in the article. Very informative for anyone who wants to know more about the ASPARTAME CONTROVERSY. And the link is valid according to Wikipedia policy (meaning that every link to google video or youtube is judged per case) Immortale (talk) 19:39, 8 March 2009 (UTC)

GAO87 - recommended reading - Other sources?

I would like to ask editors working this page to read GAO,‘HRD-87-46 It is available here : http://archive.gao.gov/d28t5/133460.pdf I plan to add information from that document and from the hearings and testimony surrounding the failed 'The Aspartame Safety Act of 1985' as proposed by Howard Morton Metzenbaum. I have thus far not been able to find the transcripts or text of that Act and any help would be greatly appreciated.

I would also like to ask everyone involved to stay calm and avoid making hasty deletions without discussion on this page, thank you.Unomi (talk) 11:36, 8 March 2009 (UTC)

Government hearings are not reliable sources per WP:MEDRS. A simple mention of the hearings is sufficient. The last thing I want is politicians deciding medical and scientific conclusions. OrangeMarlin ^{Talk• Contributions} 16:36, 8 March 2009 (UTC)

Well, that is pretty much exactly what has happened, the original experiments that were submitted in 1973/4 were found to be 'deficient' which led to the original marketing ban. The taskforce and UAREP reviewed the experiments and found them to be problematic to the degree where the task force questioned Searles ability to conduct research into the safety of their products. The FDA taskforce and the UAREP were charged with 'authenticating' the experiments, which in this context simply means that the data that searle had on file matched the data that they submitted to the FDA in the first place. From the GAO87: (the 1975 taskforce found) serious deficiencies in Searle’ operations and practices which undermine the basis for reliance on Searle’ integrity in conducting high quality animal research to accurately determine or characterize the toxic potential of its products.” and They(the 1975 taskforce) believed the FDA should conclude whether the results from a study could be used in evaluating a product’ toxic potential. So basically in spite of these discrepancies : The PBOI used its authority to refuse Mr. Turner’ request for a retrospective quality review of Searle’ studies because it believed CFSAN and UAREP had already resolved those questions. How had they 'resolved' those issues? From the GAO87: In carrying out its review of the aspartame studies, UAREP noted that when the Searle studies were performed (1970’ few standards for laboratory work were required. Therefore, UAREP stated it reviewed the studies using methods and interpretation common to research laboratories around 1970. I don't know if that included rolling up and dropping acid or not but it certainly does not inspire the greatest of confidence. The GAO87 lists numerous discrepancies for EACH of the experiments and while it states that individually these discrepancies did not result in statistically significant differences.. yet from the GAO87: Hazleton Laboratory performed the Multigeneration Rat Study reviewed by UAREP. UAREP noted “the consumption of aspartame was from 25 to 38 percent lower than planned at certain stages of the study.” However UAREP found “fewer discrepancies or problems in this study than in most of the other studies [it] reviewed.

Based on the above outlined 'authentication' and apparently the 'persuasive Japanese Brain study' Commissioner Hayes overruled the PBOI and allowed Aspartame in solid foods.

GAO87 states: However, GAO did not evaluate the interpretation of the scientific issues raised or the adequacy of FDA'S resolution of issues on the studies used for aspartame’ approval, nor did it determine aspartame’ safety

Also: According to the department lawyer on the panel, the Commissioner could not use the Japanese study as support for aspartame’ approval. In his decision, the Commissioner stated he had sufficient evidence to make a final decision and the Japanese study merely provided addi- tional support for his conclusion

Basically what all this points to is that Aspartames access to the market is based on the acceptance of flaws found in 15 studies initially submitted to the FDA in 1974. This is truly mind boggling, and looks to be a matter of public record. I am looking for the transcripts of Metzenbaum et al for more sources, I would also be very interested in finding out exactly what happened to the proposed bill. Unomi (talk) 17:53, 8 March 2009 (UTC)

"Finding out" on your own, even if you use government documents to do so, is difficult to do successfully without overstepping some basic Wikipedia guidelines such as WP:OR. In controversial articles such as this one, it's always best to edit using independent coverage of the events in secondary sources. Keepcalmandcarryon (talk) 18:16, 8 March 2009 (UTC)

one of the most thoroughly tested and studied food additives the agency has ever approved

Does anyone have a near exhaustive list of these tests?
Does anyone know why the PBOI was 'compelled' to base its judgment on no more than 3 studies regarding oncogenicity?
Does anyone have a link to the Japanese brain study which apparently is so persuasive? — Preceding unsigned comment added by Unomi (talk • contribs) 08:35, 8 March 2009 (UTC)
Unomi (talk) 16:39, 8 March 2009 (UTC)

I don't understand why the pro-aspartame people use the statement "one of the most thoroughly tested and studied food additives the agency has ever approved" in their defense. You know what the most thoroughly tested additive is (non-food though)? Nicotine. And if you didn't know it, that's not safe either. Immortale (talk) 19:46, 8 March 2009 (UTC)

Please remember that the talk page is not to be used as a discussion forum. Keepcalmandcarryon (talk) 21:31, 8 March 2009 (UTC)

Don't make me report you, Keepcalm, the sentence "one of the most thoroughly tested and studied food additives the agency has ever approved" is in the lead of the article and I and Unomi question its validation. Don't come to my talk page lecturing me about not using wikipedia for discussions. This is a valid issue for the article. Immortale (talk) 21:53, 8 March 2009 (UTC)

It is attributed to a WP:RS. Stop being disruptive. Verbal chat 22:03, 8 March 2009 (UTC)

Immortale, nicotine has nothing to do with this article, although you are certainly welcome to report me for anything you like, even a heinous 1RR violation. Keepcalmandcarryon (talk) 21:22, 9 March 2009 (UTC)

Latest edits by keepcalm

this is rather uncalled for.
Line 8 : serious deficiencies in Searle’ operations and practices which undermine the basis for reliance on Searle’ integrity in conducting high quality animal research to accurately determine or characterize the toxic potential of its products.” That is a DIRECT quote from the FDA 1975 Task Force. You can find it on page 83 of GAO87
Significantly Three of the five panel members reviewing the brain tumor issue did not believe Searle’s studies conclusively showed aspartame did not cause brain tumors. This is stated directly in GAO87, it is notable and important in terms of underscoring the controversy.

Of 67 scientists who responded to a 1987 questionnaire by the US GAO, all but twelve were "generally" or "very confident" in the safety of aspartame. 26 said they were "somewhat concerned" and twelve had "major concerns" about aspartame's safety.
VS
In 1987 a questionnaire was sent to 96 researchers by the US GAO, of the 67 respondents 43 claimed to be involved in Aspartame research and 26 claimed no aspartame research experience. Of the 43 researchers that had Aspartame experience 9 had 'Major concerns; little if any confidence in aspartame's safety', 12 were 'Somewhat concerned' and 20 'Few if any concerns' 2 did not respond to the question. Of the 26 with no claims of Aspartame research 3 had 'Major Concerns', 12 'Somewhat concerned' and 9 'Few, if any concerns'. Of the 67 respondents 32 indicated that further action should be taken, this ranged from 'require additional warnings or quantity labels' (22 respondents, 15 of which claimed Aspartame research experience), to 'Withdraw the approval for use of Aspartame in any food product(10 respondents, 7 of which claimed Aspartame research experience).
Which one would you say conveys the most meaningful information? Please note that the 'middle case' reads 'I am somewhat concerned about the safety of Aspertame; I am generally confident in the safety of Aspertame' which kind of makes me glad that the GAO doesn't consider itself scientifically competent. The washington post article is not generally accessible, the GAO87 is and it would seem that WP gathers the information, it is used to source here, from the GAO87. I will endeavor to recreate the tables from the GAO87 for this article in the future, leave the detailed questionnaire summary in the interim.

NutraPoison and Sweet Misery are relevant in terms of highlighting the controversy, please note that they are not used as sources, they are not 'endorsed' simply topic relevant links.

I am going to undo your deletes, please discuss here before deleting in the future. Thank you.

If anything it goes the other way: don't make additions (especially slanted ones) without discussion. The burden is on the one who adds the material to justify it. Tom Harrison ^Talk 20:48, 8 March 2009 (UTC)

I have justified it, please read the section you just posted to. If you take objection to my justification, discuss it here. What makes you say it is 'slanted'?

There is nothing 'slanted' about it, it reflects the information in the GAO much closer than what you have reverted to. Both lines that you seem to take objection to are DIRECT QUOTES FROM GAO87. The rewriting of the section regarding the questionnaires is much more accurate than it was before.

Again, if you choose to delete my edits please leave cogent explanations. Thank you.

Advice regarding original research was left above and, it would seem, ignored. Regarding the external links, please see WP:ELNO. Keepcalmandcarryon (talk) 21:32, 8 March 2009 (UTC)

Please be specific in regards to what it is you consider Original Research. I added 2 direct quotes from GAO87 and I included detail from source regarding the questionnaire data. Where is the 'original research' ? Unomi (talk) 22:11, 8 March 2009 (UTC)

In regards to the external links please see http://en.wikipedia.org/wiki/Wikipedia:ELNO#Links_to_be_considered #3 Again, the external links are not used as source, they are directly relevant to 'Aspartame Controversy'. Unomi (talk) 22:18, 8 March 2009 (UTC)

Please see WP:NOR. As for your external links. Not worthy of discussion. OrangeMarlin ^{Talk• Contributions} 23:02, 8 March 2009 (UTC)

I truly cannot see what it is about using direct quotations from GAO that makes you consider it Original Research. Please be specific. Also, 'not worthy of discussion' is mighty poor form. Obviously a documentary regarding 'Aspertame Controversy' is relevant to 'Aspertame Controversy'. Unomi (talk) 23:23, 8 March 2009 (UTC)

Please see WP:NOR, WP:NPOV, WP:WEIGHT, WP:MEDRS, WP:FRINGE, WP:VERIFY, and WP:CIVIL for good measure. Oh, and you're approaching tendentious editing. OrangeMarlin ^{Talk• Contributions} 23:33, 8 March 2009 (UTC)

I am new here, please spell it out for me in plain English as you seem to have all those rules down pat. Thank you for your assistance and understanding. Are you telling me that GAO87 is NOR/NPOV/WEIGHT/MEDRS/FRINGE/VERIFY ? also I do not see how you can accuse me of bad faith and then try CIVIL on me. I am adding content, this is all from the GAO87, if you have not read it, this would be an excellent time to familiarize yourself with its contents Unomi (talk) 23:49, 8 March 2009 (UTC)

The tendentious editing was a nice touch, please refer to http://en.wikipedia.org/wiki/Wikipedia:Requests_for_arbitration/Hkelkar#Removal_of_sourced_edits_made_in_a_neutral_narrative_is_disruptive Unomi (talk) 00:09, 9 March 2009 (UTC)

Sniff. Sniff. Damn someone forgot to wash some socks out. OrangeMarlin ^{Talk• Contributions} 08:22, 9 March 2009 (UTC)

Separate section for GAO87

I am considering creating a new section on GAO87 just after Approval in the US, is everyone ok with that? This would let the section on scientific studies come into its own and probably clean up the appearance of the article. Looking forwards to your response Unomi (talk) 00:21, 9 March 2009 (UTC)

"...is everyone ok with that?" Hint...if you haven't gotten the message by now...you aren't getting support and just asking this question after the edit warring you have been involved with is a rather disruptive action. -- Fyslee (talk) 03:17, 9 March 2009 (UTC)

I am not really sure what you mean, there was an issue with reverts and deletions which hopefully you will be able to address more fully, in order to reach a consensus on what we consider fit to include. What do you find problematic about including information from the GAO87? Please spell out your concerns. Do you believe the GAO87 is a faulty source? You really do need to answer this question, consensus is not about everyone 'liking' the content, it is about NPOV/NOR and what we consider valid sources. If you wish to have a say in this matter you *must* partake in the discussion. I am hoping that you will be open to reasoned discourse in this matter, sincerely Unomi (talk) 04:18, 9 March 2009 (UTC)

[First paragraph copied from my talk page.] You need to get that consensus before you do anything more about this. You should have been blocked by now, so you are very lucky that you've been treated far better than you deserve. Even if you were to get support elsewhere at Wikipedia (I see you have been forum shopping....a questionable and sanctionable practice here), you will still have to come to consensus with the editors who are editing that article. Even if you place what you think is a perfect edit in the article, it can and will likely get removed if the other editors don't support it. If you work in a collaborative manner with the other editors, and develop TOGETHER with them a version they find acceptable, then you can feel relatively certain that your hard work will be there tomorrow, and that THEY will defend it, because it is also their version. The edit warring has to stop. This is not the place to "right great wrongs". What you wish to add contributes nothing to the article. The source has already been used and summarized, and an article shouldn't depend too much on one source, especially an old and very outdated one like that. It's really only of historical interest, and the history of this controversy has already been covered pretty well.

The next step really isn't necessary, since I have answered your concerns with my last two sentences. If you insist on proceeding (which might be considered disruptive, but .....):

To proceed with the process of gaining a consensus, start a new section and place your proposed addition there. Then discuss that first version with other editors. If you all can come up with a revised version that is satisfactory to all, then you can proceed. Until then you're stuck here on the talk page. You see, the BOLD, revert, discuss cycle only has one round. It isn't meant to be repeated. Repeating it can get you blocked pretty fast. You're already on borrowed time. You've been engaged in an edit war and need to stop it and discuss. Now's the time. -- Fyslee (talk) 04:56, 9 March 2009 (UTC)

Hi and sorry

I am sorry for reverting multiple times. I know now that there is no justification to keep reverting. I am new and I believe that the material should be mentioned. Someone told me that I should ask the Fringe noticeboard on if this information can be added and how it could be added. I am going to post there and I would like others to participate in the discussion. Thanks Unomi (talk) 02:08, 9 March 2009 (UTC)

The fringe board post is http://en.wikipedia.org/wiki/Wikipedia:Fringe_theories/Noticeboard#Need_some_help_over_on__Aspartame_Controversy TIA Unomi (talk) 02:25, 9 March 2009 (UTC)

General Accounting Office - Food Additive Approval Process Followed for Aspartame

In 1987, at the request of Senator Metzenbaum, the GAO compiled and published GAO/HRD-87-46. The US Government Accountability Office concluded that the food additive approval process had been followed for aspartame. A draft version of the report was made available to the Department of Health & Human Services which agreed that the report accurately and fairly represented the FDA's actions regarding the approval of aspertame.

As part of the 1987 GAO report a questionnaire was sent to 96 researchers in order to obtain opinions on aspartame's safety and current research. Sixty-nine responded, a summary of their responses is given in the following tables.
Respondents' Opinions on Aspertame's Safety

Opinion on aspartame's safety	Aspertame researchers a	Others b	All Respondents
Major Concerns; little if any confidence in aspertame's safety	9	3	12
Somewhat concerned; generally confident of aspartame’s safety	12	14	26
Few, if any, concerns; very confident of aspertame's safety	20	9	29
Did not respond to this question	2	0	2
Total	43	26	69

^a Individuals who said they have conducted research on aspertame's safety.
^b Individuals who said they have not conducted research on aspertame's safety.

Of the 69 respondents 32 indicated that some action should be taken on aspertame to modify or inform the public.
Note that the numbers in the table below do not add up to 32 as respondents could indicate more than one action.
Respondents' Opinions on Actions That Should Be Taken To Protect Consumers

Actions	Aspertame researchers a	Others b	All respondents
Require additional warning or quantity labels on products containing aspertame	15	7	22
Increase public awareness of the concerns about aspartame	13	7	20
Provide more information to medical personnel on suspected adverse reactions to aspartame	12	7	19
Limit the use of aspartame to certain populations	12	4	16
Limit the types of products containing aspartame	8	4	12
Withdraw the approval for use of aspertame in any food product	7	3	10
Other	6	3	9

^a Individuals who said they have conducted research on aspertame's safety.
^b Individuals who said they have not conducted research on aspertame's safety.

request for comments regarding proposed minor restructuring and addition of information from GAO87

As per Fyslee's recommendation I am asking for discussion and co-editing of a proposed restructuring that would see GAO87 have its own section rather than being bundled rather haphazardly together with 'Scientific Studies'. I propose that the first paragraph of 'Scientific Studies' is merged into this proposed section, the sentence

“ Of 67 scientists who responded to a 1987 questionnaire by the US GAO,[1]:16,76-81 all but twelve were "generally" or "very confident" in the safety of aspartame. 26 said they were "somewhat concerned" and twelve had "major concerns" about aspartame's safety ”

is tortured English at best. Perhaps we can do something to reduce the size of the tables holding the questionnaire results.

I ask you to add content to the above section but to contain commentary and discussion to this section. I also wish to take this moment to make something clear, I take exception to being called an 'advocate'. If anything I am a consummate skeptic, my wish is merely that the information that is available in sources (such as GAO87) are represented correctly and with NPOV. I hope that we can all take a step back and try to avoid a 'Us vs Them' attitude. While it is true the first information that I have added could be construed as an effort to 'support' the claims of those that hold aspartame to be dangerous, bear in mind that I had little time to add anything else before getting embroiled in controversy of my own. In due time I hope to add to the body of evidence that holds aspartame harmless, but first the basic points of the controversy must be rendered clear.

This is my first experience with wikipedia and as such I had a touch of excitement regarding the whole thing, I hope it will continue to be exciting but hopefully less combative as we move forwards. I ask for your patience and support. I apologize in advance if this is taken to be soapboxing or whatever, I am here to stay and I might as well introduce myself properly (Hi).

GAO87 is, as far as I know, the most recent in-depth look at the history of FDA approval of aspartame. It has been signed off on by HHS, NutraSweet Co. and obviously the GAO. It contains a distillation of the findings of the 1975 task force, the UAREP, PBOI and 1980 FDA panel. There is to my mind very little reason to discount it. While it is true that it is used to source a fair few things, this only underscores its relative importance. Where possible we should (perhaps?) attribute them to the primary source whereas GAO87 acts as a secondary source.

Please bear in mind that this is an article on 'Aspertame Controversy', the onus is on us to debunk it, not bury it. Thanks again Unomi (talk) 06:49, 9 March 2009 (UTC)

There is absolutely no reason to be civil or nice to you any further, since you have pushed and pushed and pushed. First, the report is 20 years old. Second, it is not a reliable source. Third, hundreds of studies that are reliable supersede the report. Fourth, you are attempting to give undue weight to an unreliable, outdated, and unscientific report. Finally, we don't have to debunk anything--if it can't be supported by reliable sources, it does not exist. The controversy has been debunked, and you have provided NOTHING, absofuckinglutely NOTHING to counteract that. You are wasting our time, and you should stop. Once again, I insist that you read WP:NPOV, WP:WEIGHT, WP:MEDRS, etc. Finally, please read WP:NOTAFORUM. You are attempting to use this discussion as your personal soapbox. STOP. NOW. OrangeMarlin ^{Talk• Contributions} 08:20, 9 March 2009 (UTC)

Wikilawyering WP:WL is not allowed and because some people here seldom read the links that are refered to, it means:

1. Using formal legal terms in an inappropriate way when discussing Wikipedia policy;

2. Abiding by the letter of a policy or guideline while violating its principles;

3. Asserting that the technical interpretation of Wikipedia:Policies and guidelines should override the principles they express;

4. Misinterpreting policy or relying on technicalities to justify inappropriate actions.

This article has been a long effort by some biased editors who believe that Aspartame Controversy is fringe and don't allow anything that disprove that. Fact is that only when I brought in NEUTRAL editors, they would conclude these biased editors were wrong. But among themselves they act like a mob. Now, when I look at other wikipedia articles that contain some kind of controversy, for example the http://en.wikipedia.org/wiki/Moonlanding_hoax, there is far more space, arguments, sources accredited to the side that believes the hoax is true. In the aspartame article it's not allowed. The above mentioned Poll, even though 20 years old is completely valid, UNTIL you find a newer poll that is equally or more valid (meaning that at least 67 scientists who have worked with aspartame participated). I can already tell you that such a newer poll doesn't exist, so this poll is the only independent source that shows where the scientific community stands regarding aspartame. The majority of the studies done by the industry, if they are hundreds, are not reliable sources. Most studies didn't last more than 1 or 2 days. You cannot determine long-term effects by doing so. You can only turn up the numbers in statistics and claiming that yet another study shows aspartame is safe. Wikipedia visitors are smarter than that and they will look for more reliable articles outside Wikipedia. Immortale (talk) 09:23, 9 March 2009 (UTC)

Ok. After adding the section below, I started scrolling up.

Hard to tell what the heck is going on. (And honestly not sure if I should wade into it...)

If willing, would someone be so kind as to neutrally summarise what's going on? - jc37 09:58, 9 March 2009 (UTC)

This article, like many articles on fringe science or pseudoscience, has two regular groups of editors: one group deriving its edits from the broad medical literature, which defines the point of view of Wikipedia on such topics, and the other group advancing the fringe position, placing weight on minority studies by dismissing the wider findings as, in their opinion, flawed. Because this article is about the controversy, fringe positions that would not receive much if any coverage in the main article, Aspartame, should be described, but care must be taken not to lend too much weight to these positions and also to describe the "mainstream" (scientific) criticism of them. The result of the tension between science and pseudoscience is often an uneasy detente.

Occasionally, a new editor with a passion for the topic arrives, displaying an uncanny familiarity with Wikipedia and a propensity for tendentious editing, such as rewriting large portions of the article with a decided slant, adding external links in contravention of WP:ELNO, filling the talk page with homemade tables of data from original research, edit warring over reversions, requesting comment before familiarising him/herself with Wikipedia guidelines, reporting single edits by others to the 3RR noticeboard, etc. That seems to be what is going on. Keepcalmandcarryon (talk) 21:51, 9 March 2009 (UTC)

First of all, I did not approach this article as a 'fringe science or pseudoscience' article, simply as as an article, I think alot of this tension would be resolved if parties involved took a NPOV in this regard. It is very hard to disregard the well documented and widely reported fact that aspertame has been the center of controversy, the desire to exclude well sourced information regarding this is worrying.

It is a gross misrepresentation to say that 3 direct quotes and a 'copy' of tables constitutes either orginal research or 'rewriting large portions'. Unomi (talk) 06:30, 10 March 2009 (UTC)

UNINDENT - In an effort to ascertain the WP:RS of GAO87 I have opened a section over on WP:RSN. I have also opened a section trying to find out the applicability of WP:OR over on WP:ORN. I ask editors involved to read and understand WP:DRNC, WP:NINJA, Removal of sourced edits made in a neutral narrative is disruptive, information suppression and WP:CIVIL. So far the unsurprising response has been that GAO87 is WP:RS. I also wish to impress upon the editors that the rules of wikipedia apply, no matter if it is 'fringe' or not. Feel free to assist in the constitution of the GAO87 section. Unomi (talk) 06:06, 10 March 2009 (UTC)

The General Accounting Office report is absolutely a WP:RS, and no one has disputed its RS status. It is also a primary source, over twenty years old, and should not, as you propose, have its own section in the article per WP:WEIGHT. Further, your data mining of the report is original research. Keepcalmandcarryon (talk) 15:01, 10 March 2009 (UTC)

The GAO87 is indeed 22 years old, an oft cited reference in this article and in the aspartame article, are you suggesting that we should strike it as a reference? I wager not. It is also only a primary source, in this sense, for the questionnaire data, the rest of the report acts as a secondary source regarding the process with which aspartame was approved. The information regarding the questionnaire data is already represented in the article but in such torturous English that it borders on WP:PN clearly this needs to be presented in a way that is more clear and correct. I think your opinion that it should not have its own section is premature. It is clearly an important document in the history of aspertame. It also very elegantly is able to summarize 'the story thus far' from the POV of 1987 GAO.

I fail to see what it is that you consider 'data mining', are you talking about my attempts to improve the article by providing the direct quote from the FDA Task Force's regarding their opinion of the quality of Searles' studies?

Or the simple statement of fact that 3 out 5 panelists did not feel that Searle had proven that aspertame did not cause cancer?

I would wager that the direct reproduction of the questionnaire tables is the least contentious and best quality conveyance of the information which we already include but is currently formulated in a decidedly POV form.

It is clear that these 3 items fanned the flames of the controversy, to not include them would be WP:POV, and go against WP:NPOVREASON and WP:DUE. Unomi (talk) 22:58, 10 March 2009 (UTC)

Reference to research

• [13]

Has quite a few links. However, be sure to try to determine the reliability of the sources. (See also WP:MEDRS.)

In looking them over I was surprised that: Hustler did an article on this? (You're kidding.)

So a quick search later, and found several pages having the same text. The below being one such example.

• [14]

Enjoy : ) - jc37 09:54, 9 March 2009 (UTC)

The story thus far - for jc37

Well, I hope I don't get banned for honoring your request as good as I can..
Basically I was bored, skimmed for large google vids and came across 'Sweet Misery', I decided to see what wikipedia had to offer on it and found it to be extremely thin.
I decided to read some of the sources and came across some oddities in terms of the 'interpretations' and 'selective information' that was published on the WP entry. So I decided to add some direct quotes, some of which were incongruous with the existing text, such as http://en.wikipedia.org/w/index.php?title=Aspartame_controversy&diff=275927280&oldid=275878804 . These were lifted verbatim from the GAO87, properly referenced with page numbers etc. So I could not understand why it was being reverted, I asked for clarifications but got merely NPOV without any justification as what it was they considered NPOV, I thought that they believed that I had made it up, so I asked them to refer to GAO87 and put the changes back in. I then tried to find help in resolving the issue as the reverting editors seemed to refuse direct communication, by this time I was in the unfortunate position of having exposed myself unwittingly to 3RR. I figured, ok, so I will stop editing that section and add other information that I felt was relevant to the article. I figured that this would probably eventually blow over and we would find consensus, so I devoted myself to creating the full tables for the questionnaire data as this would probably the least contentious way of delivering the information therein. This was not well received.
I took the advice to seek advice on fringe, an editor who had previously been involved stated on there that we were sorting it out. Here on the talk page he suggested(albeit with a caveat) that I create the section that I wanted to add so we could work out suitable content together. I found this positive and constructive and proceeded to do so as well as creating a meta section for further discussion, I figured that clearing the air would be a good start and tried to introduce myself and my position to my co-editors in an attempt to restore civility and rational discourse. That was not very well received either..
Anyway, that is my perception of the events that led up to this, hopefully other editors can add their perspective on this as well. Unomi (talk) 11:10, 9 March 2009 (UTC)