Palmoplantar keratoderma: Difference between revisions
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Palmoplantar keratodermas''' are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soles, with autosomal recessive and dominant, X-linked, and acquired forms all having been described.<ref name="Fitz2" />{{rp|505}}<ref name="Andrews">James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. ISBN 0721629210.</ref>{{rp|211}} |
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== Clinical patterns == |
== Clinical patterns == |
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Revision as of 11:23, 28 April 2010
| Palmoplantar keratoderma | |
|---|---|
| Specialty | Dermatology  |
errrr you black cunt Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soles, with autosomal recessive and dominant, X-linked, and acquired forms all having been described.[1]: 505 [2]: 211
Clinical patterns
Clinically, three distinct patterns of palmoplantar keratoderma may be identified[1]: 505 :
- Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life.[1]: 505 Restated, diffuse palmoplantar keratoderma is an autosomal dominant disorder in which hyperkeratosis is confined to the palms and soles.[3] The two major types can have a similar clinical appearance:[3]
- Diffuse epidermolytic palmoplantar keratoderma (Vörner keratoderma)
- Diffuse nonepidermolytic palmoplantar keratoderma (Unna–Thost keratoderma)
- Focal palmoplantar keratoderma
- Punctate palmoplantar keratoderma
Genetics
Epidermolytic palmoplantar keratoderma has been associated with keratin 9 and keratin 16.[4]
Nonepidermolytic palmoplantar keratoderma has been associated with keratin 1 and keratin 16.[5]
See also
References
- ^ a b c Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0721629210.
- ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 740. ISBN 1-4160-2999-0.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Online Mendelian Inheritance in Man (OMIM): 144200
- ^ Online Mendelian Inheritance in Man (OMIM): 600962
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