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{{PBB_Summary
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| summary_text = The protein encoded by this gene is one of the three catalytic subunits of [[protein phosphatase 1]] (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5499| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is one of the three catalytic subunits of [[protein phosphatase 1]] (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5499| accessdate = }}</ref>
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==Interactions==
==Interactions==
PPP1CA has been shown to [[Protein-protein_interaction|interact]] with [[LMTK2]],<ref name=pmid12393858>{{cite journal |last=Wang |first=Hong |authorlink= |coauthors=Brautigan David L |year=[[2002]]|month=Dec. |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49605–12 |publisher= |location = United States| issn = 0021-9258| pmid = 12393858 |doi = 10.1074/jbc.M209335200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPP1R15A]],<ref name=pmid12724406>{{cite journal |last=Hung |first=Wesley J |authorlink= |coauthors=Roberson Rachel S, Taft Jaime, Wu Daniel Y |year=[[2003]]|month=May. |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions |journal=Mol. Cell. Biol. |volume=23 |issue=10 |pages=3477–86 |publisher= |location = United States| issn = 0270-7306| pmid = 12724406 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.10.3477-3486.2003 |pmc=164759 }}</ref><ref name=pmid12016208>{{cite journal |last=Wu |first=Daniel Y |authorlink= |coauthors=Tkachuck Douglas C, Roberson Rachel S, Schubach William H |year=[[2002]]|month=Aug. |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 |publisher= |location = United States| issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11564868>{{cite journal |last=Connor |first=J H |authorlink= |coauthors=Weiser D C, Li S, Hallenbeck J M, Shenolikar S |year=[[2001]]|month=Oct. |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 |publisher= |location = United States| issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99861 }}</ref> [[AKAP11]],<ref name=pmid12147701>{{cite journal |last=Tanji |first=Chie |authorlink= |coauthors=Yamamoto Hideki, Yorioka Noriaki, Kohno Nobuoki, Kikuchi Kunimi, Kikuchi Akira |year=[[2002]]|month=Oct. |title=A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta |journal=J. Biol. Chem. |volume=277 |issue=40 |pages=36955–61 |publisher= |location = United States| issn = 0021-9258| pmid = 12147701 |doi = 10.1074/jbc.M206210200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10209101>{{cite journal |last=Schillace |first=R V |authorlink= |coauthors=Scott J D |year=[[1999]]|month=Mar. |title=Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 |journal=Curr. Biol. |volume=9 |issue=6 |pages=321–4 |publisher= |location = ENGLAND| issn = 0960-9822| pmid = 10209101 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0960-9822(99)80141-9 }}</ref> [[Host cell factor C1]],<ref name=pmid10637318>{{cite journal |last=Ajuh |first=P M |authorlink= |coauthors=Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I |year=[[2000]]|month=Feb. |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex |journal=Nucleic Acids Res. |volume=28 |issue=3 |pages=678–86 |publisher= |location = ENGLAND| issn = | pmid = 10637318 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/28.3.678 |pmc=102561 }}</ref> [[PHACTR3]],<ref name=pmid12925532>{{cite journal |last=Sagara |first=Junji |authorlink= |coauthors=Higuchi Tsukasa, Hattori Yukiko, Moriya Mie, Sarvotham Haritha, Shima Hiroshi, Shirato Haruki, Kikuchi Kunimi, Taniguchi Shunichiro |year=[[2003]]|month=Nov. |title=Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure |journal=J. Biol. Chem. |volume=278 |issue=46 |pages=45611–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12925532 |doi = 10.1074/jbc.M305227200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Protein kinase R]],<ref name=pmid12138106>{{cite journal |last=Tan |first=Seng-Lai |authorlink= |coauthors=Tareen Semih U, Melville Mark W, Blakely Collin M, Katze Michael G |year=[[2002]]|month=Sep. |title=The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation |journal=J. Biol. Chem. |volume=277 |issue=39 |pages=36109–17 |publisher= |location = United States| issn = 0021-9258| pmid = 12138106 |doi = 10.1074/jbc.M205109200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BCL2-like 1 (gene)|BCL2-like 1]],<ref name=pmid12115603>{{cite journal |last=Ayllón |first=Verónica |authorlink= |coauthors=Cayla Xavier, García Alphonse, Fleischer Aarne, Rebollo Angelita |year=[[2002]]|month=Jul. |title=The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad |journal=Eur. J. Immunol. |volume=32 |issue=7 |pages=1847–55 |publisher= |location = Germany| issn = 0014-2980| pmid = 12115603 |doi = 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BCL2L2]],<ref name=pmid12115603/> [[CDC5L]],<ref name=pmid11101529>{{cite journal |last=Ajuh |first=P |authorlink= |coauthors=Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I |year=[[2000]]|month=Dec. |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}</ref> [[PPP1R8]],<ref name=pmid12788942>{{cite journal |last=Jin |first=Qiming |authorlink= |coauthors=van Eynde Aleyde, Beullens Monique, Roy Nivedita, Thiel Gerald, Stalmans Willy, Bollen Mathieu |year=[[2003]]|month=Aug. |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30677–85 |publisher= |location = United States| issn = 0021-9258| pmid = 12788942 |doi = 10.1074/jbc.M302273200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10637318/> [[SMARCB1]],<ref name=pmid12016208/> [[KvLQT1]],<ref name=pmid11799244>{{cite journal |last=Marx |first=Steven O |authorlink= |coauthors=Kurokawa Junko, Reiken Steven, Motoike Howard, D'Armiento Jeanine, Marks Andrew R, Kass Robert S |year=[[2002]]|month=Jan. |title=Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel |journal=[[Science (journal)|Science]] |volume=295 |issue=5554 |pages=496–9 |publisher= |location = United States| issn = | pmid = 11799244 |doi = 10.1126/science.1066843 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BRCA1]]<ref name=pmid12438214>{{cite journal |last=Liu |first=Ying |authorlink= |coauthors=Virshup David M, White Raymond L, Hsu Lih-Ching |year=[[2002]]|month=Nov. |title=Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha |journal=Cancer Res. |volume=62 |issue=22 |pages=6357–61 |publisher= |location = United States| issn = 0008-5472| pmid = 12438214 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PPP1R9B]].<ref name=pmid10194355>{{cite journal |last=Hsieh-Wilson |first=L C |authorlink= |coauthors=Allen P B, Watanabe T, Nairn A C, Greengard P |year=[[1999]]|month=Apr. |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue=14 |pages=4365–73 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 10194355 |doi = 10.1021/bi982900m | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
PPP1CA has been shown to [[Protein-protein interaction|interact]] with [[LMTK2]],<ref name=pmid12393858>{{cite journal |last=Wang |first=Hong |authorlink= |coauthors=Brautigan David L |year=[[2002]]|month=Dec. |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49605–12 |publisher= |location = United States| issn = 0021-9258| pmid = 12393858 |doi = 10.1074/jbc.M209335200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPP1R15A]],<ref name=pmid12724406>{{cite journal |last=Hung |first=Wesley J |authorlink= |coauthors=Roberson Rachel S, Taft Jaime, Wu Daniel Y |year=[[2003]]|month=May. |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions |journal=Mol. Cell. Biol. |volume=23 |issue=10 |pages=3477–86 |publisher= |location = United States| issn = 0270-7306| pmid = 12724406 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.10.3477-3486.2003 |pmc=164759 }}</ref><ref name=pmid12016208>{{cite journal |last=Wu |first=Daniel Y |authorlink= |coauthors=Tkachuck Douglas C, Roberson Rachel S, Schubach William H |year=[[2002]]|month=Aug. |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 |publisher= |location = United States| issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11564868>{{cite journal |last=Connor |first=J H |authorlink= |coauthors=Weiser D C, Li S, Hallenbeck J M, Shenolikar S |year=[[2001]]|month=Oct. |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 |publisher= |location = United States| issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99861 }}</ref> [[AKAP11]],<ref name=pmid12147701>{{cite journal |last=Tanji |first=Chie |authorlink= |coauthors=Yamamoto Hideki, Yorioka Noriaki, Kohno Nobuoki, Kikuchi Kunimi, Kikuchi Akira |year=[[2002]]|month=Oct. |title=A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta |journal=J. Biol. Chem. |volume=277 |issue=40 |pages=36955–61 |publisher= |location = United States| issn = 0021-9258| pmid = 12147701 |doi = 10.1074/jbc.M206210200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10209101>{{cite journal |last=Schillace |first=R V |authorlink= |coauthors=Scott J D |year=[[1999]]|month=Mar. |title=Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 |journal=Curr. Biol. |volume=9 |issue=6 |pages=321–4 |publisher= |location = ENGLAND| issn = 0960-9822| pmid = 10209101 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0960-9822(99)80141-9 }}</ref> [[Host cell factor C1]],<ref name=pmid10637318>{{cite journal |last=Ajuh |first=P M |authorlink= |coauthors=Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I |year=[[2000]]|month=Feb. |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex |journal=Nucleic Acids Res. |volume=28 |issue=3 |pages=678–86 |publisher= |location = ENGLAND| issn = | pmid = 10637318 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/28.3.678 |pmc=102561 }}</ref> [[PHACTR3]],<ref name=pmid12925532>{{cite journal |last=Sagara |first=Junji |authorlink= |coauthors=Higuchi Tsukasa, Hattori Yukiko, Moriya Mie, Sarvotham Haritha, Shima Hiroshi, Shirato Haruki, Kikuchi Kunimi, Taniguchi Shunichiro |year=[[2003]]|month=Nov. |title=Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure |journal=J. Biol. Chem. |volume=278 |issue=46 |pages=45611–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12925532 |doi = 10.1074/jbc.M305227200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Protein kinase R]],<ref name=pmid12138106>{{cite journal |last=Tan |first=Seng-Lai |authorlink= |coauthors=Tareen Semih U, Melville Mark W, Blakely Collin M, Katze Michael G |year=[[2002]]|month=Sep. |title=The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation |journal=J. Biol. Chem. |volume=277 |issue=39 |pages=36109–17 |publisher= |location = United States| issn = 0021-9258| pmid = 12138106 |doi = 10.1074/jbc.M205109200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BCL2-like 1 (gene)|BCL2-like 1]],<ref name=pmid12115603>{{cite journal |last=Ayllón |first=Verónica |authorlink= |coauthors=Cayla Xavier, García Alphonse, Fleischer Aarne, Rebollo Angelita |year=[[2002]]|month=Jul. |title=The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad |journal=Eur. J. Immunol. |volume=32 |issue=7 |pages=1847–55 |publisher= |location = Germany| issn = 0014-2980| pmid = 12115603 |doi = 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BCL2L2]],<ref name=pmid12115603/> [[CDC5L]],<ref name=pmid11101529>{{cite journal |last=Ajuh |first=P |authorlink= |coauthors=Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I |year=[[2000]]|month=Dec. |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}</ref> [[PPP1R8]],<ref name=pmid10637318/><ref name=pmid12788942>{{cite journal |last=Jin |first=Qiming |authorlink= |coauthors=van Eynde Aleyde, Beullens Monique, Roy Nivedita, Thiel Gerald, Stalmans Willy, Bollen Mathieu |year=[[2003]]|month=Aug. |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30677–85 |publisher= |location = United States| issn = 0021-9258| pmid = 12788942 |doi = 10.1074/jbc.M302273200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[SMARCB1]],<ref name=pmid12016208/> [[KvLQT1]],<ref name=pmid11799244>{{cite journal |last=Marx |first=Steven O |authorlink= |coauthors=Kurokawa Junko, Reiken Steven, Motoike Howard, D'Armiento Jeanine, Marks Andrew R, Kass Robert S |year=[[2002]]|month=Jan. |title=Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel |journal=[[Science (journal)|Science]] |volume=295 |issue=5554 |pages=496–9 |publisher= |location = United States| issn = | pmid = 11799244 |doi = 10.1126/science.1066843 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BRCA1]]<ref name=pmid12438214>{{cite journal |last=Liu |first=Ying |authorlink= |coauthors=Virshup David M, White Raymond L, Hsu Lih-Ching |year=[[2002]]|month=Nov. |title=Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha |journal=Cancer Res. |volume=62 |issue=22 |pages=6357–61 |publisher= |location = United States| issn = 0008-5472| pmid = 12438214 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PPP1R9B]].<ref name=pmid10194355>{{cite journal |last=Hsieh-Wilson |first=L C |authorlink= |coauthors=Allen P B, Watanabe T, Nairn A C, Greengard P |year=[[1999]]|month=Apr. |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue=14 |pages=4365–73 |publisher= |location = United States| issn = 0006-2960| pmid = 10194355 |doi = 10.1021/bi982900m | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist}}
{{Reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further_reading
| citations =
| citations =
*{{cite journal | author=Cohen PT |title=Protein phosphatase 1--targeted in many directions. |journal=J. Cell. Sci. |volume=115 |issue= Pt 2 |pages= 241–56 |year= 2002 |pmid= 11839776 |doi= }}
*{{cite journal | author=Cohen PT |title=Protein phosphatase 1--targeted in many directions. |journal=J. Cell. Sci. |volume=115 |issue= Pt 2 |pages= 241–56 |year= 2002 |pmid= 11839776 |doi= }}
*{{cite journal | author=Barker HM, Jones TA, da Cruz e Silva EF, ''et al.'' |title=Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. |journal=Genomics |volume=7 |issue= 2 |pages= 159–66 |year= 1990 |pmid= 2161401 |doi=10.1016/0888-7543(90)90536-4 }}
*{{cite journal | author=Barker HM, Jones TA, da Cruz e Silva EF, ''et al.'' |title=Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. |journal=Genomics |volume=7 |issue= 2 |pages= 159–66 |year= 1990 |pmid= 2161401 |doi=10.1016/0888-7543(90)90536-4 }}
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{{refend}}
{{PDB Gallery|geneid=5499}}
{{PDB Gallery|geneid=5499}}

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Revision as of 14:37, 14 November 2011

Template:PBB Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

PPP1CA has been shown to interact with LMTK2,[1] PPP1R15A,[2][3][4] AKAP11,[5][6] Host cell factor C1,[7] PHACTR3,[8] Protein kinase R,[9] BCL2-like 1,[10] BCL2L2,[10] CDC5L,[11] PPP1R8,[7][12] SMARCB1,[3] KvLQT1,[13] BRCA1[14] and PPP1R9B.[15]

References

  1. ^ Wang, Hong (2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. 277 (51). United States: 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  2. ^ Hung, Wesley J (2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. 23 (10). United States: 3477–86. doi:10.1128/MCB.23.10.3477-3486.2003. ISSN 0270-7306. PMC 164759. PMID 12724406. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  3. ^ a b Wu, Daniel Y (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  4. ^ Connor, J H (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  5. ^ Tanji, Chie (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40). United States: 36955–61. doi:10.1074/jbc.M206210200. ISSN 0021-9258. PMID 12147701. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  6. ^ Schillace, R V (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6). ENGLAND: 321–4. doi:10.1016/S0960-9822(99)80141-9. ISSN 0960-9822. PMID 10209101. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  7. ^ a b Ajuh, P M (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3). ENGLAND: 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  8. ^ Sagara, Junji (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46). United States: 45611–9. doi:10.1074/jbc.M305227200. ISSN 0021-9258. PMID 12925532. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  9. ^ Tan, Seng-Lai (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation". J. Biol. Chem. 277 (39). United States: 36109–17. doi:10.1074/jbc.M205109200. ISSN 0021-9258. PMID 12138106. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  10. ^ a b Ayllón, Verónica (2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". Eur. J. Immunol. 32 (7). Germany: 1847–55. doi:10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7. ISSN 0014-2980. PMID 12115603. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  11. ^ Ajuh, P (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  12. ^ Jin, Qiming (2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. 278 (33). United States: 30677–85. doi:10.1074/jbc.M302273200. ISSN 0021-9258. PMID 12788942. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  13. ^ Marx, Steven O (2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science. 295 (5554). United States: 496–9. doi:10.1126/science.1066843. PMID 11799244. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  14. ^ Liu, Ying (2002). "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer Res. 62 (22). United States: 6357–61. ISSN 0008-5472. PMID 12438214. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  15. ^ Hsieh-Wilson, L C (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). United States: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)

Further reading

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