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{{PBB_Summary
{{PBB_Summary
| section_title =
| section_title =
| summary_text = The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5528| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez"/>
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==Interactions==
==Interactions==
PPP2R5D has been shown to [[Protein-protein_interaction|interact]] with [[PPP2R1B]],<ref name=pmid8703017>{{cite journal |last=McCright |first=B |authorlink= |coauthors=Rivers A M, Audlin S, Virshup D M |year=[[1996]]|month=Sep. |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm |journal=J. Biol. Chem. |volume=271 |issue=36 |pages=22081–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8703017 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.36.22081 }}</ref> [[liprin-alpha-1]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |year=[[2005]]|month=Oct. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HAND2]]<ref name=pmid14636580>{{cite journal |last=Firulli |first=Beth A |authorlink= |coauthors=Howard Marthe J, McDaid Jennifer R, McIlreavey Leanne, Dionne Karen M, Centonze Victoria E, Cserjesi Peter, Virshup David M, Firulli Anthony B |year=[[2003]]|month=Nov. |title=PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation |journal=Mol. Cell |volume=12 |issue=5 |pages=1225–37 |publisher= |location = United States| issn = 1097-2765| pmid = 14636580 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(03)00425-8 |unused_data=DUPLICATE DATA: pmid = 14636564 }}</ref> and [[PPP2CA]].<ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref><ref name=pmid8703017/>
PPP2R5D has been shown to [[Protein-protein interaction|interact]] with [[PPP2R1B]],<ref name=pmid8703017>{{cite journal |last=McCright |first=B |authorlink= |coauthors=Rivers A M, Audlin S, Virshup D M |year=[[1996]]|month=Sep. |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm |journal=J. Biol. Chem. |volume=271 |issue=36 |pages=22081–9 |publisher= |location = United States| issn = 0021-9258| pmid = 8703017 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.36.22081 }}</ref> [[liprin-alpha-1]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |year=[[2005]]|month=Oct. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HAND2]]<ref name=pmid14636580>{{cite journal |last=Firulli |first=Beth A |authorlink= |coauthors=Howard Marthe J, McDaid Jennifer R, McIlreavey Leanne, Dionne Karen M, Centonze Victoria E, Cserjesi Peter, Virshup David M, Firulli Anthony B |year=[[2003]]|month=Nov. |title=PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation |journal=Mol. Cell |volume=12 |issue=5 |pages=1225–37 |publisher= |location = United States| issn = 1097-2765| pmid = 14636580 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(03)00425-8 |unused_data=DUPLICATE DATA: pmid = 14636564 }}</ref> and [[PPP2CA]].<ref name=pmid8703017/><ref name=pmid18782753>{{cite journal |last=Goudreault |first=Marilyn |authorlink= |coauthors=D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein |journal=Mol. Cell Proteomics |volume=8 |issue=1 |pages=157–71 |publisher= |location = United States| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2621004 }}</ref>


==References==
==References==
{{reflist}}
{{Reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
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| citations =
| citations =
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
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{{PDB Gallery|geneid=5528}}
{{PDB Gallery|geneid=5528}}

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Revision as of 14:38, 14 November 2011

Template:PBB Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene.[1][2]

Template:PBB Summary

Interactions

PPP2R5D has been shown to interact with PPP2R1B,[3] liprin-alpha-1,[4] HAND2[5] and PPP2CA.[3][6]

References

  1. ^ McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  2. ^ "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform".
  3. ^ a b McCright, B (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36). United States: 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  4. ^ Rual, Jean-François (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  5. ^ Firulli, Beth A (2003). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5). United States: 1225–37. doi:10.1016/S1097-2765(03)00425-8. ISSN 1097-2765. PMID 14636580. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |unused_data= ignored (help)
  6. ^ Goudreault, Marilyn (2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1). United States: 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)

Further reading

Template:PBB Further reading

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