Cataplexy: Difference between revisions
Not to be confused with Catalepsy |
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==External links== |
==External links== |
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* [http://http://www.wakeupnarcolepsy.org/about-narcolepsy/what-is-narcolepsy/ Wake Up Narcolepsy's Description of Cataplexy] |
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* [http://web.archive.org/web/20070812162803/www.narcolepsy.org.uk/narcolepsy/cataplexy/attacks/show_page Narcolepsy Association UK] |
* [http://web.archive.org/web/20070812162803/www.narcolepsy.org.uk/narcolepsy/cataplexy/attacks/show_page Narcolepsy Association UK] |
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* [http://www.bbc.co.uk/health/physical_health/conditions/narcolepsy1.shtml BBC's Article on the condition] |
* [http://www.bbc.co.uk/health/physical_health/conditions/narcolepsy1.shtml BBC's Article on the condition] |
Revision as of 20:50, 16 March 2012
Cataplexy | |
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Specialty | Neurology ![]() |
- Not to be confused with Catalepsy.
Cataplexy is a sudden and transient episode of loss of muscle tone, often triggered by emotions. It is a rare disease[1] (prevalence of fewer than 5 per 10,000 in the community), but affects roughly 70% of people who have narcolepsy.[2] Cataplexy can also be present as a side effect of SSRI Discontinuation Syndrome.
The term cataplexy originates from the Greek κατά (kata, meaning "downwards"), and πληξις (plēxis, meaning "striking" or "hitting" [from plessein meaning "to strike or hit"]).
Presentation
Cataplexy manifests itself as muscular weakness which may range from a barely perceptible slackening of the facial muscles to the dropping of the jaw or head, weakness at the knees, or a total collapse. Usually the speech is slurred, vision is impaired (double vision, inability to focus), but hearing and awareness remain normal. These attacks are triggered by strong emotions such as exhilaration, anger, fear, surprise, orgasm, awe, embarrassment, and laughter. A person's efforts to stave off cataplectic attacks by avoiding these emotions may greatly diminish their quality of life, and they may become severely restricted emotionally if diagnosis and treatment is not begun as soon as possible.[3]
Cataplexy may be partial or complete, affecting a range of muscle groups, from those controlling facial features to (less commonly) those controlling the entire body.[4]
- Arm weakness
- Sagging jaw
- Drooping head
- Slumping of the shoulders
- Slurred speech
- Generalized weakness
- Knee buckling
When cataplexy happens often, or cataplexy attacks make patients fall or drop things, it can have serious effects on normal activities. It can cause accidents and be embarrassing when it happens at work or with friends. For example, people with cataplexy may not pick up babies because they are afraid they may drop them.[5]
Treatment
Despite its relation to narcolepsy, in most cases, cataplexy must be treated differently and separate medication must be taken. For many years, cataplexy has been treated with tricyclic antidepressants such as imipramine, clomipramine or protriptyline. However these can have unpleasant side-effects and so have been generally replaced by newer drugs such as venlafaxine.
For cataplexy associated with narcolepsy, Xyrem (sodium oxybate) is often recommended.[6]
Monoamine oxidase inhibitors may be used to manage both cataplexy and the REM sleep-onset symptoms of sleep paralysis and hypnagogic hallucinations.[7]
Emerging Therapies
Emerging therapies include Hypnotic Psychotherapy, Hypocretin Gene Therapy, and Hypocretin Cell Transplantation for narcolepsy-cataplexy.[8][9]
See also
References
- ^ "Prevalence". Retrieved May 16, 2009.
- ^ "Narcolepsy Fact Sheet". Retrieved 2011-06-23.
- ^ "Narcolepsy and Cataplexy". NODSS Narcolepsy and Overwhelming Daytime Sleep Society of Australia. Retrieved 2007-09-19.
- ^ "Cataplexy". Sleep Disorders - Cataplexy. 2007. Retrieved 2007-09-19.
- ^ "Cataplexy Introduction for Patients". Jazz Pharmaceuticals, Inc. 2007. Archived from the original on 2007-04-26. Retrieved 2007-09-19.
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21206362, please use {{cite journal}} with
|pmid=21206362
instead. - ^ Thomas F. Anders, MD (2006). "Narcolepsy". Childhood Sleep Disorders. Armenian Medical Network. Retrieved 2007-09-19.
- ^ "Emerging Therapies in Narcolepsy-Cataplexy" (PDF). Retrieved 2011-06-23.
- ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.sleep.2009.07.011, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1016/j.sleep.2009.07.011
instead.