Talk:Ketamine

Cleanup

This article is a little messy and could do with some rearranging. The medicinal uses part needs some subsections, and some thought might be given to partial merge with the medical research section. — Preceding unsigned comment added by Testem (talk • contribs) 10:28, 15 January 2014

Discovery

In this edit, it is claimed that ketamine was developed (by Craig Newlands) before it was synthesized (by Calvin Stevens) which is a logical impossibility. How do you develop something before it exists? I realize that what the source says, but I am skeptical of the source, especially when other reliable sources (see for example here and here) don't mention Craig Newlands. Boghog (talk) 13:22, 24 December 2014 (UTC)

A candidate for immediate reversion if the source doesn't mention him, IMHO. Testem (talk) 13:51, 24 December 2014 (UTC)

The source does mention him, but the source itself does not make any sense. Boghog (talk) 15:21, 24 December 2014 (UTC)

sources are messy on this, and use "develop" in a sloppy way. probably Newlands discovered it and parke-davis developed it, both chemically (working out better synthesis) and clinically. this document - not a reliable source - acknowledges the confusion in the sources concerning who "developed" and/or "discovered" it. this is the kind of question i like... i will work on this over the next few days. short term this source says Newlands "discovered" and Parke-David developed, which is the most likely right answer at this point. Jytdog (talk) 17:00, 24 December 2014 (UTC)

Thanks Jytdog. The last source above at least makes sense. Boghog (talk) 20:59, 24 December 2014 (UTC)

I deleted my previous correction about who discovered Ketamine because I could not find reliable evidence suggesting that Craig Newlands ever existed. Gcastellanos (talk) 12:35, 30 May 2015 (UTC)

Neutrality and referencing in recent edit

I have concerns about the large recent edit made by Leprof 7272 (talk · contribs), with edit summary "Added recent statistics and references regarding deaths in young adults, 2005-2013. For section that ,ore than 95% covers governmental regulation, the heading of "Legal status" was elevated to replace the misnomer "Society and culture". Le Prof", (diff). It seems somewhat UNDUE because of the stridency of tone and number of repetitions; also some of the refs are not compatible with WP:MEDRS. The following passage in particular strikes me as not belonging:

One expose of a young person's death concludes:

"…cocaine, MDMA, mephedrone and LSD can end up damaging people and some can become addict[ed], but it appears none of these drugs has the ability to wreck the body or leave users mentally marooned in the way that ketamine does. Rather than being a window into the soul, for some ketamine has turned into a way of mollifying pain or getting through the day, like heroin and diazepam."

This is referenced to a website and a newspaper. Looie496 (talk) 14:06, 8 June 2015 (UTC)

The rest of the edits seem just a bit imbalanced but this excerpt is particularly out of place. I have removed it. Testem (talk) 20:21, 9 June 2015 (UTC)

Very good neurological chart comparison of Ketamine and other NMDAR antagonist, possible to re-draw as free?

This image would be great to have drawn by someone who has the ability to make it different enough and release it free on Wiki-media to put on the ketamine page. It's a comparison of the binding profile of Ketamine & DXM to the G-coupled protein receptor sites. Nagelfar (talk) 19:38, 24 August 2015 (UTC)

Ketamine Usage with TMS

Success in treatment of depression with Ketamine is optimized when it is used in conjunction with transcranial magnetic stimulation (TMS). A link outlining the treatment may be found here: Researchers Receive Patent for New Depression and Pain Treatment. Article is from the Chicago Tribune. Journal published case reports can be found here and here. SunSw0rd (talk) 22:51, 25 August 2015 (UTC)

Please read WP:MEDRS Best Doc James (talk · contribs · email) 00:03, 26 August 2015 (UTC)

Intro Paragraph

Common side effects include psychological reactions as the medication wears off.[4] These reactions may include agitation, confusion, or psychosis.[4][8] Elevated blood pressure and muscle tremors are relatively common, while low blood pressure and a decrease in breathing is less so.[4][8] Spasms of the larynx may rarely occur.

The claim that side effects occur "as the medication wears off" doesn't seem to have any basis. There's no indication in either source (both drugs.com pages) when the side effects occur. This is problematic since it implies lingering effects that may not exist and are not indicated in the references. (Though the special note in ref [4] specifically indicates that while some side effects may recur over a 24h period, no residual psych. effects are known.) Unless anyone has any further info on the side effects, I'd say remove the "as the medication wears off" portion. ParoXoN (talk) 23:11, 16 February 2016 (UTC)

it is best to read the body if something seems wrong in the lead. the lead just summarizes the body. there was more content there for it, and a ref Jytdog (talk) 00:51, 17 February 2016 (UTC)

reactions and supplication

supposedly alternatively, ketamin, inhibits psychosis within the hippocampus, as a prospective psi medication. next, the secret of ancient ketae, est min, elemental "antimony" ketamin could mix with selenium, also seemingly entails combination with benz-thio cyclyenol analogue. lasty, wild keta minerals exist next to the andes such as local of argenina and pacific side of continent southern, — Preceding unsigned comment added by Wezenlucif (talk • contribs) 02:33, 24 February 2016 (UTC)

Expand Depression Section

There have been numerous studies stating Ketamine's benefit for treatment-resistant depression, but the information in the depression section is spare and presented very tentatively. The article does not describe how the drug acts on depression (hypothesized MOA), the emergence of ketamine clinics delivering infusions to treatment resistant patients, or Ketamine's relationship to the development of glutamatergic antidepressants. The articles on ketamine's enantiomers are even more fully fleshed-out in this respect. 68.185.202.126 (talk) 04:38, 26 April 2016 (UTC)ddiamondds