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[[File:Galega officinalis MHNT.BOT.2007.40.22.jpg|thumb|''Galega officinalis'' - [[MHNT]]]]
[[File:Galega officinalis MHNT.BOT.2007.40.22.jpg|thumb|''Galega officinalis'' - [[MHNT]]]]
'''''Galega officinalis''''', commonly known as '''galega''',<ref name=GRIN>{{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?70971 |title=USDA GRIN Taxonomy |accessdate=8 July 2014}}</ref> '''goat's-rue''',<ref name=BSBI07>{{cite web |title=BSBI List 2007 |publisher=Botanical Society of Britain and Ireland |url=http://www.bsbi.org.uk/BSBIList2007.xls |format=xls |accessdate=2014-10-17}}</ref> '''French lilac''',<ref name = AP>{{cite journal|title=Metformin: Myths, misunderstandings and lessons from history|journal=Australian Prescriber|date=April 2013|volume=36|issue=2|pages=38–39|author=Shenfield, G|url=http://www.australianprescriber.com/magazine/36/2/38/9}}</ref> '''Italian fitch''',<ref name = AP/> or '''professor-weed''',<ref name = AP/> is an herbaceous plant in the [[Faboideae]] subfamily. It is native to the [[Middle East]], but it has been naturalized in [[Europe]], western [[Asia]], and western [[Pakistan]]. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as [[green manure]].<ref name=invasive>{{Cite journal| last=Lasseigne| first=Alex| title=Invasive PLants of the Eastern United States: Galega sp.| publisher= US Department of Agriculture| year= 2003| url=http://www.invasive.org/eastern/other/Galega.html| postscript=<!-- Bot inserted parameter. Either remove it; or change its value to "." for the cite to end in a ".", as necessary. -->{{inconsistent citations}}}}</ref> However, the plant has proved too toxic for widespread agricultural use, with the potential to induce tracheal frothing, pulmonary oedema, hydrothorax, hypotension, paralysis and death.<ref name= Bailey >Bailey CJ, Campbell IW, Chan JCN, Davidson JA, Howlett HCS, Ritz P (eds). 2007. ''Metformin: the Gold Standard. A Scientific handbook''; Chichester: Wiley. [http://media.johnwiley.com.au/product_data/excerpt/19/04707254/0470725419.pdf Chapter 1: Galegine and anti diabetic plants]</ref>
'''''Galega officinalis''''', commonly known as '''galega''',<ref name=GRIN>{{cite web |url=http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?70971 |title=USDA GRIN Taxonomy |accessdate=8 July 2014}}</ref> '''goat's-rue''',<ref name=BSBI07>{{cite web|title=BSBI List 2007 |publisher=Botanical Society of Britain and Ireland |url=http://www.bsbi.org.uk/BSBIList2007.xls |format=xls |accessdate=2014-10-17 |deadurl=yes |archiveurl=http://www.webcitation.org/6VqJ46atN?url=http://www.bsbi.org.uk/BSBIList2007.xls |archivedate=2015-02-25 |df= }}</ref> '''French lilac''',<ref name = AP>{{cite journal|title=Metformin: Myths, misunderstandings and lessons from history|journal=Australian Prescriber|date=April 2013|volume=36|issue=2|pages=38–39|author=Shenfield, G|url=http://www.australianprescriber.com/magazine/36/2/38/9}}</ref> '''Italian fitch''',<ref name = AP/> or '''professor-weed''',<ref name = AP/> is an herbaceous plant in the [[Faboideae]] subfamily. It is native to the [[Middle East]], but it has been naturalized in [[Europe]], western [[Asia]], and western [[Pakistan]]. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as [[green manure]].<ref name=invasive>{{Cite journal| last=Lasseigne| first=Alex| title=Invasive PLants of the Eastern United States: Galega sp.| publisher= US Department of Agriculture| year= 2003| url=http://www.invasive.org/eastern/other/Galega.html| postscript=<!-- Bot inserted parameter. Either remove it; or change its value to "." for the cite to end in a ".", as necessary. -->{{inconsistent citations}}}}</ref> However, the plant has proved too toxic for widespread agricultural use, with the potential to induce tracheal frothing, pulmonary oedema, hydrothorax, hypotension, paralysis and death.<ref name= Bailey >Bailey CJ, Campbell IW, Chan JCN, Davidson JA, Howlett HCS, Ritz P (eds). 2007. ''Metformin: the Gold Standard. A Scientific handbook''; Chichester: Wiley. [http://media.johnwiley.com.au/product_data/excerpt/19/04707254/0470725419.pdf Chapter 1: Galegine and anti diabetic plants]</ref>


Its name derives from ''gala'' ([[milk]]) and ''ago'' (to bring on), as ''Galega'' has been used as a [[galactogogue]] in small domestic animals (hence the name "Goat's rue"). ''Galega bicolor'' is a synonym. It is a hardy perennial that blooms in the summer months.
Its name derives from ''gala'' ([[milk]]) and ''ago'' (to bring on), as ''Galega'' has been used as a [[galactogogue]] in small domestic animals (hence the name "Goat's rue"). ''Galega bicolor'' is a synonym. It is a hardy perennial that blooms in the summer months.

Revision as of 10:00, 7 January 2017

Galega officinalis
Galega officinalis flowers
Scientific classification
Kingdom:
Plantae
(unranked):
Angiosperms
(unranked):
Eudicots
(unranked):
Rosids
Order:
Fabales
Family:
Fabaceae
Subfamily:
Papilionoideae
Genus:
Galega
Species:
G. officinalis
Binomial name
Galega officinalis
Galega officinalis - MHNT

Galega officinalis, commonly known as galega,[1] goat's-rue,[2] French lilac,[3] Italian fitch,[3] or professor-weed,[3] is an herbaceous plant in the Faboideae subfamily. It is native to the Middle East, but it has been naturalized in Europe, western Asia, and western Pakistan. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as green manure.[4] However, the plant has proved too toxic for widespread agricultural use, with the potential to induce tracheal frothing, pulmonary oedema, hydrothorax, hypotension, paralysis and death.[5]

Its name derives from gala (milk) and ago (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name "Goat's rue"). Galega bicolor is a synonym. It is a hardy perennial that blooms in the summer months.

G. officinalis is used as a food plant by the larva of Coleophora vicinella, a species of moth.

Distribution

In 1891, G. officinalis was introduced to Cache County, Utah, for use as a forage crop.[citation needed] It escaped cultivation and is now a weed and agricultural pest, though it is still confined to that county. As a result, it has been placed on the Federal Noxious Weed List in the United States. It was collected in Colorado, Connecticut and New York prior to the 1930s, and in Maine and Pennsylvania in the 1960s, but no more collections have been made in these areas since and the populations are presumed to have died out. It has also been found in Argentina, Chile, Ecuador, and New Zealand.[4]

Uses

G. officinalis has been known since the Middle Ages for relieving the symptoms of diabetes mellitus. Upon analysis, it turned out to contain compounds related to guanidine, a substance that decreases blood sugar by mechanisms including a decrease in insulin resistance, but were too toxic for human use. The active ingredient in the French lilac is galegine or isoamylene guanidine.[6] Georges Tanret identified an alkaloid from this plant, galegine, that was less toxic (than guanidine[clarification needed]), and this was evaluated in unsuccessful clinical trials in patients with diabetes in the 1920s and 1930s.[5][6]

Other related compounds were being investigated clinically at this time, including biguanide derivatives. This work led ultimately to the discovery of metformin (Glucophage), currently used for the management of diabetes[7] and the older agent phenformin.[8] The study of galegine and related molecules in the first half of the 20th century is regarded as an important milestone in the development of oral antidiabetic pharmacotherapy.[9]

Galega officinalis - from Thomé
Flora von Deutschland, Österreich und der Schweiz 1885

References

  1. ^ "USDA GRIN Taxonomy". Retrieved 8 July 2014.
  2. ^ "BSBI List 2007". Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-02-25. Retrieved 2014-10-17. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  3. ^ a b c Shenfield, G (April 2013). "Metformin: Myths, misunderstandings and lessons from history". Australian Prescriber. 36 (2): 38–39.
  4. ^ a b Lasseigne, Alex (2003). "Invasive PLants of the Eastern United States: Galega sp". US Department of AgricultureTemplate:Inconsistent citations {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: postscript (link)
  5. ^ a b Bailey CJ, Campbell IW, Chan JCN, Davidson JA, Howlett HCS, Ritz P (eds). 2007. Metformin: the Gold Standard. A Scientific handbook; Chichester: Wiley. Chapter 1: Galegine and anti diabetic plants
  6. ^ a b Witters, L. A. (2001). "The blooming of the French lilac". Journal of Clinical Investigation. 108 (8): 1105–7. doi:10.1172/JCI14178. PMC 209536. PMID 11602616.
  7. ^ Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B (2009). "Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes". Diabetes Care. 32 (1): 193–203. doi:10.2337/dc08-9025. PMC 2606813. PMID 18945920.
  8. ^ Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006 Jan 25;(1):CD002967.
  9. ^ Bailey CJ, Day C (2004). "Metformin: its botanical background". Practical Diabetes Int. 21 (3): 115–117. doi:10.1002/pdi.606.
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