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Hello - this information is wrong. Thermo Fisher didn´t buy QIAGEN yet. https://www.ft.com/content/17b99524-5d27-11ea-b0ab-339c2307bcd4 The transaction, which is expected to be completed in the first half of 2021, is subject to the satisfaction of customary closing conditions, including the receipt of applicable regulatory approvals, the adoption of certain resolutions relating to the transaction at an Extraordinary General Meeting of QIAGEN’s shareholders, and completion of the tender offer.
m Changed Thierry Bernard title from Interim CEO to CEO
Line 5: Line 5:


{{Infobox company
{{Infobox company
| name = QIAGEN N.V.
| name = QIAGEN N.V.
| logo = [[Image:Qiagen.svg|130px]]
| logo = [[Image:Qiagen.svg|130px]]
| type = [[Naamloze vennootschap]]
| type = [[Naamloze vennootschap]]
| traded_as = {{NYSE|QGEN}}<br>{{FWB|QIA}}<br>[[Russell 1000 Index|Russell 1000 Component]]
| traded_as = {{NYSE|QGEN}}<br>{{FWB|QIA}}<br>[[Russell 1000 Index|Russell 1000 Component]]
| founder =
| founder =
| area_served =
| area_served =
| key_people = Thierry Bernard <small> (Interim Chief Executive Officer) </small>, Prof. Dr. Håkan Björklund <ref>https://corporate.qiagen.com/about-us/Who-we-are/management/supervisory-board/</ref> <small>(Supervisory Director and Chairman of the Supervisory Board)</small>
| key_people = Thierry Bernard <small> (Chief Executive Officer) </small>, Prof. Dr. Håkan Björklund <ref>https://corporate.qiagen.com/about-us/Who-we-are/management/supervisory-board/</ref> <small>(Supervisory Director and Chairman of the Supervisory Board)</small>
| industry = [[Biotechnology]]
| industry = [[Biotechnology]]
| products =
| products =
| revenue = US $1,501.848 million <small>(2018)</small> <ref>https://corporate.qiagen.com/newsroom/press-releases/2018/20180131_q4fy2018_results</ref>
| revenue = US $1,501.848 million <small>(2018)</small> <ref>https://corporate.qiagen.com/newsroom/press-releases/2018/20180131_q4fy2018_results</ref>
| website = {{url|www.qiagen.com}}
| website = {{url|www.qiagen.com}}
| operating_income = US $403.3 million <small>(2018 adjusted, excluding restructuring charge)</small> <ref>Adjusted operating income excluding restructuring charges and other items such as business integration, acquisition-related costs, litigation settlements and the amortization of intangible assets acquired in business combinations. https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release</ref>
| operating_income = US $403.3 million <small>(2018 adjusted, excluding restructuring charge)</small> <ref>Adjusted operating income excluding restructuring charges and other items such as business integration, acquisition-related costs, litigation settlements and the amortization of intangible assets acquired in business combinations. https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release</ref>
| assets = US $5,748.332 million <small>(end of December 2018)</small> <ref>https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/</ref>
| assets = US $5,748.332 million <small>(end of December 2018)</small> <ref>https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/</ref>
| equity = US $2,634.970 million <small>(end of December 2018)</small> <ref>https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/</ref>
| equity = US $2,634.970 million <small>(end of December 2018)</small> <ref>https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/</ref>
| num_employees = about 5,000 <small>(end of December 2018)</small> <ref>https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release</ref>
| num_employees = about 5,000 <small>(end of December 2018)</small> <ref>https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release</ref>
| divisions =
| divisions =
| subsid =
| subsid =
| foundation = {{start date and age|1984|11|29}}
| foundation = {{start date and age|1984|11|29}}
| location = [[Venlo]], [[Netherlands]] <small>(corporate)</small>; [[Hilden]] (near [[Düsseldorf]]), [[Germany]] <small>(operational)</small>
| location = [[Venlo]], [[Netherlands]] <small>(corporate)</small>; [[Hilden]] (near [[Düsseldorf]]), [[Germany]] <small>(operational)</small>
}}
}}


'''QIAGEN''' is a provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. Consolidated under the Dutch holding QIAGEN N.V., the company operates more than 35 offices in over 25 countries.<ref>[http://corporate.qiagen.com/about-us]</ref> QIAGEN's shares are listed at the [[NYSE]] (using ticker QGEN) and at the [[Frankfurt Stock Exchange]] in the Prime Standard (using ticker QIA). Thierry Bernard is the company's Interim Chief Executive Officer. The main operative headquarters are located in [[Hilden]], [[Germany]].{{Citation needed|date=March 2018}}
'''QIAGEN''' is a provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. Consolidated under the Dutch holding QIAGEN N.V., the company operates more than 35 offices in over 25 countries.<ref>[http://corporate.qiagen.com/about-us]</ref> QIAGEN's shares are listed at the [[NYSE]] (using ticker QGEN) and at the [[Frankfurt Stock Exchange]] in the Prime Standard (using ticker QIA). Thierry Bernard is the company's Chief Executive Officer. The main operative headquarters are located in [[Hilden]], [[Germany]].{{Citation needed|date=March 2018}}


== History ==
== History ==
Line 113: Line 113:
== Management ==
== Management ==
As of October 2019, the company's Executive Committee consisted of the following members:<ref name=qiagenmgt>{{cite web | url=http://corporate.qiagen.com/about-us/Who-we-are/management/executive-committee | archivedate=14 February 2018 | archiveurl=http://corporate.qiagen.com/about-us/Who-we-are/management/executive-committee | publisher=QIAGEN | title=Executive Committee }}</ref>
As of October 2019, the company's Executive Committee consisted of the following members:<ref name=qiagenmgt>{{cite web | url=http://corporate.qiagen.com/about-us/Who-we-are/management/executive-committee | archivedate=14 February 2018 | archiveurl=http://corporate.qiagen.com/about-us/Who-we-are/management/executive-committee | publisher=QIAGEN | title=Executive Committee }}</ref>
*Thierry Bernard (Interim Chief Executive Officer)<ref>{{Cite web|url=https://www.genomeweb.com/sequencing/qiagen-partners-illumina-ngs-ivd-kits-ceo-departing-preliminary-q3-revenue-growth-lowered|title=Qiagen Partners With Illumina on NGS IVD Kits; CEO Departing; Preliminary Q3 Revenue Growth Lowered|website=GenomeWeb|language=en-us|access-date=2019-10-10}}</ref>
*Thierry Bernard (Chief Executive Officer)<ref>{{Cite web|url=https://www.genomeweb.com/sequencing/qiagen-partners-illumina-ngs-ivd-kits-ceo-departing-preliminary-q3-revenue-growth-lowered|title=Qiagen Partners With Illumina on NGS IVD Kits; CEO Departing; Preliminary Q3 Revenue Growth Lowered|website=GenomeWeb|language=en-us|access-date=2019-10-10}}</ref>
*Roland Sackers (Chief Financial Officer)
*Roland Sackers (Chief Financial Officer)
*Dr. Thomas Schweins (Senior Vice President Life Science Business Area)
*Dr. Thomas Schweins (Senior Vice President Life Science Business Area)

Revision as of 12:16, 27 March 2020

QIAGEN N.V.
Company typeNaamloze vennootschap
NYSE: QGEN
FWB: QIA
Russell 1000 Component
IndustryBiotechnology
FoundedNovember 29, 1984; 39 years ago (1984-11-29)
HeadquartersVenlo, Netherlands (corporate); Hilden (near Düsseldorf), Germany (operational)
Key people
Thierry Bernard (Chief Executive Officer) , Prof. Dr. Håkan Björklund [1] (Supervisory Director and Chairman of the Supervisory Board)
RevenueUS $1,501.848 million (2018) [2]
US $403.3 million (2018 adjusted, excluding restructuring charge) [3]
Total assetsUS $5,748.332 million (end of December 2018) [4]
Total equityUS $2,634.970 million (end of December 2018) [5]
Number of employees
about 5,000 (end of December 2018) [6]
Websitewww.qiagen.com

QIAGEN is a provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. Consolidated under the Dutch holding QIAGEN N.V., the company operates more than 35 offices in over 25 countries.[7] QIAGEN's shares are listed at the NYSE (using ticker QGEN) and at the Frankfurt Stock Exchange in the Prime Standard (using ticker QIA). Thierry Bernard is the company's Chief Executive Officer. The main operative headquarters are located in Hilden, Germany.[citation needed]

History

1984-2000

In 1984, QIAGEN was established on November 29 by a team of scientists at the Heinrich Heine University Düsseldorf, Germany. Two years later, QIAGEN launched its first product, a kit for purification of plasmids – small ring-shaped DNA molecules in bacterial cells – cutting the preparation time for plasmids from between two and three days down to two hours.[citation needed] 1996 saw the initial public offering of QIAGEN on the technology-oriented Nasdaq stock exchange, becoming the first German company to do so.[8] 1997 saw the initial public offering on the Frankfurt Stock Exchange in Germany.[citation needed]

2001-present

In 2004, QIAGEN acquired key assets of Molecular Staging, Inc. Two years later, QIAGEN established its Asia regional headquarters in Shanghai. In 2007 sales reached US$649.8 million and the number of employees surpassed 2,600. Qiagen acquired Digene for US$1.6 billion, furthering QIAGEN in molecular diagnostics by revenue and diagnostics for disease prevention.[citation needed]

In 2009, QIAGEN began building its Personalized Healthcare business through the acquisition of DxS Ltd, in a deal valued at US$95 million[9] and it acquired SABiosciences Corp. in a deal valued at US$9 million.[10] At the end of 2009 QIAGEN surpassed the US$1 billion revenue mark and had over 3,500 employees. QIAGEN became one of the first companies to release a clinically verified diagnostic test for the detection of H1N1, more commonly known as Swine Flu.[11]

In 2010 QIAGEN acquired ESE GmbH,[12] giving the company access to point of need testing devices for the application of molecular diagnostic tests without laboratory infrastructure. QIAGEN launched the QIAsymphony AS and QIAsymphony RGQ platforms, adding to the company's portfolio for laboratory workflow automation and molecular test full-process automation respectively.[citation needed]

In 2011 QIAGEN acquired Ipsogen S.A. for US$101 million,[13][14] adding to the company's product and IP portfolio in the blood cancer space and developing its position in molecular diagnostics for oncology. QIAGEN also acquired Cellestis Limited for US$374 million,[15] giving the company access to QuantiFERON technology for disease detection and prevention. The company added two new offices in the Asia Pacific region in New Delhi, India and Taipei, Taiwan. The company announced a comprehensive restructuring program to focus on high-growth areas such as personalized medicine and business in emerging markets. The program includes workforce reduction and internal restructuring affecting approximately 10% of the company's 3,900 positions.[16]

In 2013, QIAGEN acquired Ingenuity Systems.[17] QIAGEN also acquired CLC bio, which offers bioinformatics analysis software.[18] In 2015, QIAGEN acquired AdnaGen's circulating tumor cell enrichment technology.[19] Qiagen also acquired Enzymatics enzyme solutions.[20] On March 2015, amanagement buyout of QIAGEN Marseille led to the creation of HalioDx.[21] In late 2015 the GeneReader NGS System was launched.[22] In 2016 QIAGEN acquired the Danish molecular diagnostics company Exiqon.[23]

In 2018 QIAGEN transferred listing to New York Stock Exchange.[24] In April 2018, QIAGEN acquired the Spanish firm STAT-Dx and launched the QIAstat-Dx molecular diagnostics platform. In September 2018 QIAGEN announced a strategic partnership with NeuMoDx to market two fully integrated systems for automated PCR.[25]

In 2019 QIAGEN announced the acquisition of Formulatrix assets to develop a digital PCR platform.[26] An additional acquisition of N-of-One, a privately held U.S. molecular decision support company and pioneer in clinical interpretation services for complex genomic data, to expand its QCI bioinformatics offerings with Real World Insights.[27] Following on from its work on the 100,000 Genome Project, Genomics England appointed the company bioinformatic support to the NHS Genomic Medicine Service and the national network of Genomic Laboratory Hubs in efforts to sequence 5 million genomes by 2023.[28] In October 2019 QIAGEN entered into an agreement with Illumina granting QIAGEN non-exclusive rights to develop and globally commercialize IVD kits to be used together with Illumina's diagnostic instruments.[29]

In 2020 Thermo Fisher Scientific announced the acquisition of QIAGEN.

Qiagen Acquisitions
  • Qiagen
    • Molecular Staging, Inc. (Acq 2004)
    • Digene
    • DxS Ltd (Acq 2009)
    • SABiosciences Corp. (Acq 2009)
    • ESE GmbH (Acq 2010)
    • Ipsogen S.A. (Acq 2011)
    • Cellestis Limited (Acq 2011)
    • Ingenuity Systems (Acq 2013)
    • CLC bio (Acq 2013)
    • Exiqon (Acq 2016)
    • STAT-Dx (Acq 2018)
    • Formulatrix (Acq 2019)
    • N-of-One (Acq 2019)
    • Molecular Staging, Inc. (Acq 2010)

Products

For QIAGEN columns, see column-based nucleic acid purification.

QIAGEN is a worldwide provider of molecular sample and assay technologies. Sample technologies are used to collect samples of tissue, fluids, etc. and stabilize, extract and purify various molecules of interest such as DNA, RNA or proteins from other cellular components. Assay technologies are then used to amplify (multiply) and enrich this small amount of isolated material to make it visible, readable and ready for interpretation. The separation and purification of genetic information is a basic precondition for further application or analysis.[citation needed]

QIAGEN provides molecular technologies offered as kits with open or specific target analytes. According to QIAGEN, the company's current portfolio covers more than 500 products and more than 2,000 patents and licenses.[30]

In 2014, QIAGEN entered into a supply agreement with Trinean for the manufacture of a QIAGEN-branded "micro-volume" spectrophotometer, to be sold under the name "QIAxpert".[31]

Application areas

Until the mid-2000s, QIAGEN was mainly a provider of sample technologies for the academic research market. QIAGEN's current product portfolio includes sample and assay technologies, specific automation solutions, and a bioinformatics analysis portfolio in 4 markets.[citation needed]

Molecular diagnostics

Molecular diagnostics detect the nucleic acids (DNA and RNA) of target diseases or pathogens in samples such as blood or tissue. These procedures can help to detect viruses and bacteria more rapidly and with greater sensitivity and specificity than other methods such as bacterial culture or immunodiagnostics.[32] Molecular diagnostics are also used to analyze individual patient's genomic information to further classify certain diseases and to determine the most appropriate treatment. QIAGEN's portfolio in molecular diagnostics covers various applications which the company divides into three main segments:[33]

• Oncology: The company's portfolio in oncology includes tests for a broad range of clinically relevant biomarkers, particularly in cancer, encompassing companion diagnostics that are marketed in combination with certain drugs, helping to guide treatment decisions. In addition, QIAGEN markets a range of gene panels for research applications in next-generation sequencing, covering dozens of genes associated with various cancers. Furthermore, the company offers technologies for the extraction and enrichment of molecular biomarkers from body fluids, supporting the development of liquid biopsies. Minimally invasive liquid biopsies hold promise to transform the diagnosis and treatment of cancer.[citation needed]

• Modulation of Immune Response: The QuantiFERON-TB Gold In-Tube Test (QFT) is regarded worldwide as the modern standard for detection of latent tuberculosis infection. According to WHO estimates, this condition affects about one-third of the world's population. As up to 10% of people with latent TB infection will develop the active disease in the course of their lives, the identification and treatment of at-risk groups with latent TB is important for sustainable control of this potentially life-threatening infectious disease.[citation needed]

• Infectious Diseases: QIAGEN offers several comprehensive test panels for detection of bacterial and viral pathogens. The portfolio encompasses assays for the detection of individual pathogens such as Influenza, HIV, Hepatitis, and healthcare-associated infections. The company also has a global leadership position in screening for high-risk types of human papillomavirus (HPV), the primary cause of cervical cancer.[citation needed]

Applied testing

Applied Testing is the use of molecular biology/diagnostics in practical, non-clinical applications such as veterinary medicine, forensics, food-quality monitoring and protection against biological hazards. QIAGEN's portfolio includes:[citation needed]

• Food safety: tests for pathogens (such as salmonella, legionella and listeria), allergens, genetically modified organisms as well as food origin and quality.

• Veterinary medicine: tests for pathogens (such as bird flu, for which Qiagen was the first company to offer an approved test) as well as pandemic prevention and monitoring.

• Forensics: tests used to identify victims, prosecute criminals and determine paternity or lineage.

Academic research

The life science research market encompasses all disciplines focusing on living organisms such as humans, animals, plants or bacteria (e.g., biochemistry, biomedicine or genetic engineering). Much of the research is done on a molecular level targeting DNA, RNA and proteins and helps scientists to comprehend basic processes in cells and organisms.[citation needed]

QIAGEN introduced the first kit for purification of plasmids – small ring-shaped DNA molecules in bacterial cells – in 1986, cutting the preparation time for plasmids from between two and three days down to two hours. The company has a global market share exceeding 70% for certain sample preparation technologies.[citation needed]

Pharmaceutical industry

Multinational pharmaceutical companies use molecular sample and assay technologies in all phases of the drug development process, from the fundamental pharmaceutical research stage, through preclinical and clinical studies, to the commercialization and application of new products.[citation needed]

QIAGEN technologies can be used to identify genes that participate in the emergence of diseases, carry out studies on the functions and interactions between genes (or proteins) in entire biological pathways, identify and validate potential biomarkers and identify and evaluate therapeutic target molecules and suitable active agent candidates. QIAGEN's products can also be used in the execution of the clinical studies.[citation needed]

Management

As of October 2019, the company's Executive Committee consisted of the following members:[34]

  • Thierry Bernard (Chief Executive Officer)[35]
  • Roland Sackers (Chief Financial Officer)
  • Dr. Thomas Schweins (Senior Vice President Life Science Business Area)
  • Dr. Barthold Piening (Senior Vice President Global Operations)
  • Dr. Jonathan Sheldon (Senior Vice President Bioinformatics Business Area)
  • Dr. Annette Koch (Senior Vice President Global and Chief Human Resources Officer)

Structure of the company

QIAGEN has a holding structure. The holding (QIAGEN N.V.) is located in Venlo, The Netherlands. The operative and European headquarters are located in Hilden, Germany. Further regional headquarters are located in Maryland for North America and Shanghai for Asia.[citation needed]

References

  1. ^ https://corporate.qiagen.com/about-us/Who-we-are/management/supervisory-board/
  2. ^ https://corporate.qiagen.com/newsroom/press-releases/2018/20180131_q4fy2018_results
  3. ^ Adjusted operating income excluding restructuring charges and other items such as business integration, acquisition-related costs, litigation settlements and the amortization of intangible assets acquired in business combinations. https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release
  4. ^ https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/
  5. ^ https://www.qiagen.com/be/about-us/investors/financial-information/key-figures/
  6. ^ https://corporate.qiagen.com/newsroom/press-releases/2019/20190204_q4_release
  7. ^ [1]
  8. ^ Peter A. Brooke, Daniel Penrice (Nov 10, 2009). A Vision for Venture Capital: Realizing the Promise of Global Venture Capital and Private Equity (Winthrop Group). ISBN 1584657995.
  9. ^ "Qiagen Acquires UK's DxS in Deal Worth up to $130M". GenomeWeb Daily News. United States: GenomeWeb. 23 September 2009. Archived from the original on 20 March 2011.
  10. ^ Vence, Tracy (16 December 2009). "QIAGEN acquires SABiosciences". BioTechniques. Archived from the original on 19 March 2014. {{cite news}}: |archive-date= / |archive-url= timestamp mismatch; 20 March 2014 suggested (help)
  11. ^ Chengpei, Zhu; Xiaomin, Zhang (12 September 2009). "Molecular firm Qiagen releases rapid H1N1 test". ChinaDaily. Archived from the original on 19 March 2014. {{cite news}}: |archive-date= / |archive-url= timestamp mismatch; 20 March 2014 suggested (help)
  12. ^ "QIAGEN Acquires ESE GmbH". News & Events. Bionity. Germany: CHEMIE.DE. 14 January 2010. Archived from the original on 19 March 2014. {{cite news}}: |archive-date= / |archive-url= timestamp mismatch; 20 March 2014 suggested (help)
  13. ^ "Qiagen Plans to Buy Cancer MDx Firm Ipsogen for $101M". 15 Jun 2011.{{cite news}}: CS1 maint: url-status (link)
  14. ^ "QIAGEN makes proposal to fully acquire Ipsogen". analytica-world.com. Germany: chemie.de. 16 June 2011. Archived from the original on 18 March 2014.
  15. ^ "QIAGEN acquires Cellestis". Medtech News. Pharmaceutical Field. United Kingdom: Health Sector Publishing. 2011. Archived from the original on 19 March 2014. {{cite news}}: |archive-date= / |archive-url= timestamp mismatch; 20 March 2014 suggested (help)
  16. ^ "QIAGEN (QGEN) Launches Productivity Enhancement Program; 8-10% of Workforce to Be Affected". StreetInsider.com. 28 November 2011. Archived from the original on 30 December 2011.
  17. ^ "QIAGEN acquires Ingenuity Systems". 29 April 2013.{{cite news}}: CS1 maint: url-status (link)
  18. ^ "QIAGEN acquires CLC bio - CLC bio". CLC bio. Retrieved 2016-04-29.
  19. ^ "Qiagen Acquires Novel Circulating Tumor Cell Technology for Liquid Biopsies". GEN News. Mar 17, 2015.
  20. ^ QIAGEN. "QIAGEN - Sample to Insight". www.qiagen.com. Retrieved 2016-04-29.
  21. ^ Staff (17 January 2018). "HalioDx Wins $22.6M in Financing toward Immunoscore Platform, U.S. Expansion". Clinical OMICs. Retrieved 19 January 2018.
  22. ^ QIAGEN. "QIAGEN - Sample to Insight". www.qiagen.com. Retrieved 2016-04-29.
  23. ^ QIAGEN. "QIAGEN announces successful completion of tender offer for shares in Exiqon". www.qiagen.com. Retrieved 2016-09-07.
  24. ^ "Qiagen To Transfer U.S. Listing Of Global Shares To Nyse". Reuters. 14 February 2018. Retrieved 14 February 2018.
  25. ^ "QIAGEN inks deal with NeuMoDx to offer next-generation systems for molecular diagnostic testing". Reuters. 17 September 2018. Retrieved 16 January 2019.
  26. ^ "Qiagen Talks New Products, Acquisitions for Digital PCR". Reuters. 8 January 2019. Retrieved 16 January 2019.
  27. ^ "Qiagen Acquires N-of-One to Add Molecular Decision Support". Reuters. 7 January 2019. Retrieved 16 January 2019.
  28. ^ Guest, Alex. "Genomics England chooses QIAGEN for 5 million genomes project | Health Tech Pulse". healthtechpulse.com.
  29. ^ "Qiagen Nixes Sequencer Development, Sees New NGS Opportunities With Illumina Deal". GenomeWeb. Retrieved 2019-10-10.
  30. ^ "Fact Sheet: QIAGEN Strategy". February 2018.
  31. ^ "Trinean, Qiagen Enter into Global Supply Agreement". News - Genomics & Proteomics. Gen. Eng. Biotechnol. News (print). Vol. 34, no. 4. 15 February 2014. p. 18.
  32. ^ DiIulio, Renee (1 March 2006). "Molecular Diagnostics: Challenges and Benefits". Clinical Lab Products. United States. OCLC 60626983. Archived from the original on 19 March 2014. {{cite news}}: |archive-date= / |archive-url= timestamp mismatch; 20 March 2014 suggested (help)
  33. ^ "Background Molecular Diagnostics". December 2015.
  34. ^ "Executive Committee". QIAGEN. {{cite web}}: Check |archiveurl= value (help)
  35. ^ "Qiagen Partners With Illumina on NGS IVD Kits; CEO Departing; Preliminary Q3 Revenue Growth Lowered". GenomeWeb. Retrieved 2019-10-10.

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