MD–PhD

This article is about MD–PhD programs. For doctor of osteopathic medicine–PhD programs, see Medical Scientist Training Program § Non-MSTP MD–PhD and DO–PhD programs.

The Doctorate of Medicine and of Philosophy (MD–PhD) is a dual doctoral degree for physician–scientists, combining the professional training of the Doctor of Medicine degree with the research expertise of the Doctor of Philosophy degree; the Ph.D. is the most advanced credential in the United States. Other dual degree programs exist, such as the joint MD–JD degree; both the JD professional degree and the MD are not universally recognized internationally, however. The National Institutes of Health currently provides 50 medical schools with Medical Scientist Training Program grants that support the training of students in MD–PhD programs at these institutions through tuition and stipend allowances. These programs are often competitive, with some admitting as few as two students per academic year. The MCAT score and GPA of MD–PhD matriculants are often higher than MD only matriculants.

Application and admissions

MD–PhD typically require or prefer candidates who have had a background in research, either under a professor as an undergraduate or have taken at least one gap year to work in a laboratory setting. The application process in addition to a personal statement required for MD-only applications also require two additional essays to describe why an applicant wants to pursue an MD–PhD and an essay describing their research background.

Training programs

In the United States, MD–PhD degrees can be obtained through dual-degree programs offered at some medical schools. The idea for an integrated training program began at Case Western Reserve University School of Medicine in 1956 and quickly spread to other research medical schools. In 1964, through the Chief of the Office of Program Planning and Evaluation Herbert H. Rosenberg, Ph.D., the National Institutes of Health (NIH) developed a grant to underwrite some universities' MD–PhD programs. This funding was distributed through the Medical Scientist Training Program (MSTP). There are also non-MSTP funded dual-degree programs, which typically provide funding through endowment funds, research assistantships, teaching assistantships, and extramural fellowships). Non-MSTP funded dual degree programs have more flexibility and can extend to degrees other than the PhD (e.g., JD and MBA degrees).

Admission to a dual degree program is not a requirement to receive MD and PhD degrees. An individual has the option to complete each degree separately through single-degree programs. However, the student is responsible for all medical school tuition and does not receive a stipend during their MD education. Furthermore, since the PhD training is not streamlined with the medical training, students will often take additional years to complete their PhD.

A PhD may also be obtained by physicians during the residency training period. This combined research and graduate-level medical education are offered by a minority of residency programs. This additional education typically extends the residency period by three to four years.

Training structure

Pre-doctoral

Upon matriculating in an MD–PhD program, students will often follow a 2-PhD-2 plan. In this system, students will complete the pre-clinical curriculum of their medical school (2 years), transition into PhD graduate training (3–5 years), and then finally complete clinical rotations (2 years).

Post-doctoral

Upon receiving the MD–PhD dual degree, physician-scientists may choose a variety of career paths. The most common continues to be residency training with additional laboratory training. However, a physician–scientist may also elect to refuse residency training, thereby having a career essentially akin to a conventional PhD scientist. A physician–scientist may also elect to work in the private sector with no further formal academic clinical nor research training.

Benefits of the dual degree program

Financial compensation

Some MD–PhD programs (all MSTPs) cover all medical school tuition, provide a stipend, and cover health insurance expenses.

Residency programs

Candidates with MD–PhD dual degrees are favorably looked upon in most residency programs.

Career flexibility

Graduates with an MD–PhD degree are generally qualified for a variety of careers in medicine and medical research. MD students, just as MD–PhD students, are also qualified for a career in medical research given enough post-graduate research experience. The issue is that careers in medicine as an MD, most commonly being a physician, pay significantly more than careers in medical research. Those who graduate MD most often accrue significant financial debt and are incentivize to seek employment as a high-paying physician to pay off debt from undergraduate and MD schooling. MD–PhD graduates nearly always graduate debt free. Thus, MD–PhD students do not have the same economic pressures to seek employment as a physician compared to their MD counterparts, and instead have the economic flexibility to seek out a career in research or any career path that can utilize the unique skills an MD–PhD had acquired over their years of education.

Career paths

The vast majority (over 80%) of MD–PhD graduates eventually choose to enter academia, government, or industry where medical research is a central component of their duties. According to a FASEB study conducted in 2000, graduates of NIH-funded MSTPs make up just 2.5% of medical school graduates each year, but after graduation, account for about one third of all NIH research grants awarded to physicians. Many MD–PhD graduates also practice clinical medicine in their field of expertise.

Notable MD–PhD physician–scientists

• Barry Blumberg – Recipient of the 1976 Nobel Prize in Physiology or Medicine along with Daniel Gajdusek for their work on the human prion disease kuru
• Francis Collins – Former Director of the National Institutes of Health and former leader of the Human Genome Project
• James DiCarlo – computational neuroscientist and Head of the MIT Department of Brain and Cognitive Sciences
• Alfred G. Gilman – Recipient of the 1994 Nobel Prize in Physiology or Medicine along with Martin Rodbell for their discoveries regarding G-proteins
• Robert Satcher – Physician, chemical engineer, and NASA astronaut who became the first orthopedic surgeon in space during STS-129
• Vilayanur S. Ramachandran – Neuroscientist known for his work in the fields of behavioral neurology and visual psychophysics
• David Satcher – 16th Surgeon General of the United States
• Chi Van Dang – Director of the Abramson Cancer Center of the University of Pennsylvania
• Christopher Duntsch – Neurosurgeon sentenced to life in prison for intentionally botching 32 surgeries that killed two patients and paralyzed two others
• Gregg L. Semenza - Pediatrician and Professor of Genetic Medicine and Nobel Prize Winner in Medicine, subsequently retracted numerous papers.
• Joseph Ladapo - Surgeon General of Florida, known for spreading misinformation.
• Bruce D. Perry - Psychiatrist and researcher in children’s mental health and neuroscience, known for developing the Neurosequential Model.
• Paul Farmer - Global health physician and medical anthropologist.
• Joshua A. Gordon - Director of the National Institute of Mental Health.
• Karl Deisseroth - Neuroscientist, Psychiatrist, D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University, and Investigator of the Howard Hughes Medical Institute, member of the advisory committee on the BRAIN Initiative.
• Emery N. Brown - Professor of Computational Neuroscience and Health Sciences and Technology, at Massachusetts Institute of Technology, and the Warren M. Zapol Professor of Anaesthesia, of Harvard Medical School, at Massachusetts General Hospital, member of the advisory committee on the BRAIN Initiative.
• Ezekiel Emanuel - American oncologist, bioethicist, and senior fellow at the Center for American Progress. Formerly a member of the COVID-19 Advisory Board.
• Milton Erickson - Psychiatrist and Psychologist, pioneer in Family Therapy and hypnosis.
• Arvid Carlsson - Swedish neuropharmacologist, received the 2000 Nobel Prize in Physiology or Medicine for respective research on the functioning of signal transduction proteins in learning, memory, and movement.
• Maurizio Pompili - Associate Professor of Psychiatry and Professor of Suicidology as part of the Faculty of Medicine and Psychology at Sapienza University of Rome, Italy. Psychiatrist and neuroscience researcher in suicide.
• Stephen Waxman - American Neuroscientist and Neurologist, Bridget M. Flaherty Professor of Neurology and of Neuroscience; Director, Center for Neuroscience and Regeneration Research

See also

• Biomedical scientist
• DPT-MPH
• Association of American Medical Colleges
• American Physician Scientists Association