Talk:GABA
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I'm surprised not to see any mention of alcohol in the list of drugs which can affect GABA. GABA movement is affected both in FASD and in direct drinking of alcohol.
"So far three general classes of GABA receptor are known, more than one of which is often represented in the same organisms. These include both so-called ionotropic receptors, which are ion channels themselves, and metabotropic receptors, which are G protein-coupled receptors that open ion channels via intermediaries (G proteins)."
Which is the third type? —The preceding unsigned comment was added by 24.211.134.8 (talk • contribs) .
- Scroll down two paragraphs: The 3 types are GABA A receptor, GABA B receptor and GABA C receptor. A and C are ionotropic, B is metabotropic. -- PFHLai 03:16, 27 September 2005 (UTC)
Effects on GABA on hGH production
There are some advertisments of GABA supplements claiming GABA instructs the brain to produce more Human Growth Hormone during deep sleep. Any thoughts?
- Advertisements claim all sorts of stuff. Any GABA you would ingest will be broken down by your digestive system way before it will ever get to your brain. Nrets 19:54, 14 March 2006 (UTC)
el acido gamma mini butirico(gaba)es un neuro transmisor y no es totalmente destruido por el sistema digestivo,soloq ue no ejerce su accion igual que en condiciones normales.Dr.Ricardo Garcias Puentes.Profesor titular.Espacialista en Medicina Interna Segundo Grado.Cuba.
better name
Should it be called Gamma-aminobutanoic acid? That is all I have ever heard it called, and it seems more accurate and consistant. 195.194.89.7 15:52, 2 March 2006 (UTC)
- Gamma-aminobutyric acid is correct. Nrets 19:54, 14 March 2006 (UTC)
- The IUPAC name is 4-aminobutanoic acid as stated in the infobox on the rhs of the article. It is usually referred to as Gamma-aminobutyric acid though. 83.147.180.185 18:58, 8 August 2007 (UTC)
Requesting more info on human effects (e.g. emotions, physical activity) of increased or decreased GABA
As opposed to just the physiological processes involved with it please
- See benzodiazepine, barbiturate and epilepsy for starters. Nrets 02:26, 17 March 2006 (UTC)
Is GABA omni-present/ pervasive? If so, how is it transported? By blood; CSF; or Glial tissue? Does it change in strength, say in sync with the Circadian rhythm? Don Nicol 11:30, 06 Jul 07
- GABA is released by GABAergic neurons (usually interneurons). It is transported in the same way as any other neurotransmitter (glutamate for instance). GABAergic neurons are indeed found everywhere. Without them the brain would be in a nearly constant epileptic state. I expect it changes both in degree of postsynaptic effect and in overall tonic levels over time, the former due at least in part to modulatory affects and the latter due to the fact that activity levels in general change with state (e.g. sleep vs. resting vs. active). digfarenough (talk) 20:47, 6 September 2007 (UTC)
GABA supplements
Considering how regulated and addictive GABA-affecting drugs like barbiturates and benzodiazepines are, I was very surprised to find that GABA is legally available as a supplement from online health stores (eg [[1]]). Is there any sort of clinical study or official statements on how well (if at all) these work for relieving anxiety, or whether or not they create any sort of dependency or tolerence effects like those drugs? 69.85.180.131 07:56, 10 November 2006 (UTC)
- My guess is that taking GABA orally will do absolutely nothing because it is unlikely to cross the blood-brain barrier and significantly interact with GABA receptors. But whether or not their products work at all doesn't matter in the supplement industry.
- That is indeed correct, GABA does not cross the blood brain barrier. However, it does have peripheral effects, and this may account for its use as a supplement. This may be worth mentioning in the article, as it does seem fairly widespread in use. Fuzzform 03:13, 2 April 2007 (UTC)
Is GABA transaminase used to produce GABA?
I've read that "However, GAD is not the only source of GABA. The Krebs cycle also serves to synthesize GABA via GABA-transaminase. " --CopperKettle 10:59, 31 December 2006 (UTC)
- Check out this[2] page for some interesting info on that topic. Includes very nice picture of biosynthetic pathway that GABA is involved in. Fuzzform 03:19, 2 April 2007 (UTC)
Data rape drug?
I use GABA for insomnia and i have found it works quite well but i had thought i had heard it is used as a date-rape drug.Does anyone know anything about this?
- You're probably thinking of GHB, the nitrogenous analogue of GABA. (Ccroberts( t · c · g ) 16:53, 7 July 2007 (UTC))
- It's the other way around, GABA is the nitrogenous analogue of GHB. 83.147.180.185 17:24, 8 August 2007 (UTC)
- Ooopsie, thanks, that would be gamma-hydroxyl analogue of GABA. (Ccroberts( t · c · g ) 18:53, 8 August 2007 (UTC))
- It's the other way around, GABA is the nitrogenous analogue of GHB. 83.147.180.185 17:24, 8 August 2007 (UTC)
Pharmacology
This section contains some inaccuracies that should be clarified: Avermectins target glutamate-gated chloride channels, not GABA receptors (e.g. Wolstenholme & Rogers, 2005). Opioids and cannabinoids affect GABA signaling indirectly, but not through GABA receptors. I have never heard of many of the other substances mentioned here to interact with GABA receptors, such as carbamazepines, fluoroquinolones or phenytoin - please include references or remove them. Valerenic acid (see Valerian (herb)) should be included (Khom et al., 2007). 193.171.174.141 13:48, 24 May 2007 (UTC)
- Deleted tramadol (see Hara et al., 2005), opioids and cannabinoids but kept carbamazepine (see Granger, et al., 1995). Boghog2 08:15, 21 October 2007 (UTC)
Acetyl GABA
Why not it could cross the blood brain barrier
Dopamine & Serotonine
Im new to this. Does GABA acts as an inhibitor to Serotonin and Dopamine? The article does not spell that out. Further, if one is suffering from to much dopamine, due to withdrawal sympoms of an dopamine antagonist (Zuclopenthixol), whould this help to eliviate acute symptoms, by preventing inhibition? Any reason to not do so? Would using GABA prevent the brain to readjust, or would the withrawal proced as usual, only with lesser sympoms? Would there be any withrawal sympoms from discontinuating the use of GABA? The answer to the questiong could potentialy be very usefull to me. Thanks.--Striver - talk 04:02, 14 February 2008 (UTC)
Is there any difference from withdrawal sympoms of an dopamine antagonist such as Zuclopenthixol and the effects of an stimulants such as Amphetamine? Would decresing Levodopa levels help to aliviate the problem? Or could spiking Pyridoxal phosphate levels help to lower dopamine levels by forcing it to be created outside the CNS? --Striver - talk 04:06, 14 February 2008 (UTC)