Idebenone
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| Elimination half-life | 18 hours |
| Excretion | urine and feces |
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| Formula | C19H30O5 |
| Molar mass | 338.439 g/mol g·mol−1 |
Idebenone (pronounced eye-deb-eh-known) is an organic compound of the quinone family and promoted commercially as a synthetic analog of Coenzyme Q10 (CoQ10).
Idebenone is claimed to have properties similar to CoQ10 in its antioxidant properties.[specify]
Idebenone is different from Coenzyme Q10 in one very important way. During a hypoxic (low oxygen) condition, CoQ10 can switch function from an anti-oxidizing to an auto-oxidizing process. This auto-oxidation rapidly produces free radicals which damage the tissues of the body.[verification needed]
Idebenone is said to perform the same functions as CoQ10 without the risk of an auto-oxidation reaction.[verification needed]
Idebenone is said to promote NGF (nerve growth factor) in the brain.[verification needed] It appears to reduce tinnitus (ringing in the ears).[verification needed] Idebenone has also been used in topical applications to treat wrinkles.
Takeda Pharmaceuticals studied Idebenone which it got approved for Alzheimer's disease and Stroke.
In a one-year test on 8 patients idebenone reduced the rate of deterioration of cardiac function in patients with Friedreich's ataxia, but without halting the progression of ataxia [1].
See also
- Free-radical theory of aging
http://en.wikipedia.org/wiki/Catena_(idebenone)