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|Systematic (IUPAC) name|
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Meclofenoxate (Lucidril), also known as centrophenoxine, is a cholinergic drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.
In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition. Meclofenoxate also increases cellular membrane phospholipids.
Side effects and contraindications
Meclofenoxate is generally considered safe.[medical citation needed] However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.[unreliable source?] Large doses may cause tight jaw clenching.
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