Meclofenoxate
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| ECHA InfoCard | 100.000.107  |
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| Formula | C12H16ClNO3 |
| Molar mass | 257.71 g·mol−1 |
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Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease.[1][2][3] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).
In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition.[4] Meclofenoxate also increases cellular membrane phospholipids.[citation needed] It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.[3]
Side effects[edit]
Meclofenoxate is considered to be very safe and high in tolerability.[3] However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.[3]
Research[edit]
Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 30–50%.[5]
Brand names[edit]
In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[6]
See also[edit]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
- ^ a b c d Maija Haavisto (1 May 2008). Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia. Lulu.com. pp. 167–. ISBN 978-1-4092-0335-3.
- ^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
- ^ The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. 1 January 2003. pp. 66–. ISBN 978-0-9668937-3-1.
- ^ Yong Zhou (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.
