Talk:Uric acid

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That's a Lot of Nitrogen!

Urine is said to be very nitrogen-rich. Is all of that nitrogen only found in the uric acid, or are there other nitrogen compounds in urine? Kyoobur9000 (talk) 02:04, 31 July 2012 (UTC)[reply]

Survival

What chemical can combine with it to separate it in urine? —Preceding unsigned comment added by Ericg33 (talk • contribs) 08:17, 28 September 2010 (UTC)[reply]

I

I thought 3 to 7ml was the normal range. I had a test recently, and that's what the doctor said about the range. Mine was up about 8.
JesseG 22:19, July 27, 2005 (UTC)

did some page formating only. I'll grab the providers MSDS form the lab when i get the chance and fill in the blanks --Ajusted dog 02:16, 6 August 2005 (UTC)[reply]

Examples of high purine and Fe sources include: sweetbreads, anchovies, sardines, liver, beef kidneys, brains, meat extracts (e.g., Oxo, Bovril), herring, mackerel, scallops, game meats, and gravy.

Gravy is a food? It's not. Someone fix... — Preceding unsigned comment added by 66.127.213.188 (talk) 21:49, 8 May 2012 (UTC)[reply]

Cleanup

1. "Uric acid is a minor end-product of nitrogen metabolism in the human body (the main product being urea), and is found in small amounts in urine.".......... actually the article should be more specific and say that uric acid is the product of PURINE CATABOLISM.

2. "A percentage of gout patients eventually get uric kidney stones" ..........What percentage would that be??? If it is significant the actual percentage should be mentioned and cited, if it is not significant than don't mention it at all.

3. "In human blood, uric acid concentrations between 3.6 and 8.3 mg/dL are considered normal by the American Medical Association, although significantly lower levels are common in vegetarians."...........First, these values are incorrect and there is a different normal range for males than for females. Also, a source needs to be cited more specific than just AMA. In addition, we must specify that it is SERUM Uric Acid as there is also a test for urinary uric acid.

(comment on item 3... when something says "in human blood", i'm not likely to interpret that as urinary uric acid level)

According to Stedman's Medical Dictionary and confirmed in the Merck, Normal Uric Acid Values are as follows: Male: 4.5-8.0 mg/dl Female: 2.5-6.2 mg/dl Child: 2.0-5.5mg/dl

Concentration in urine normal range: 250-750 mg over 24 hours for a normal diet.

4. "The disease gout in humans is associated with abnormal levels of uric acid in the system.".......This is far to vague and ambiguous. Abnormal could mean low, which is not associated with gout. What exactly is "The System"? The artice should be more specific istead of using terms like "the system", and it should indicate that gout is assiciated specifically with HYPERURICEMIA, not just "abnormal levels".

5. "While this compound is more energetic than those other wastes, it means that water loss due to elimination can be reduced to a minimum. ."......... I don't understand what this sentence is saying. It does not make sense. Please rewrite it more clearly or explain it some more.

If you all agree, please update this artice. Thank You!

Please suggest what does abnormal level means? and prevention mechanism for controlling uric acid within normal range.

addenda to "cleanup"

The number of gout sufferers who eventually get UA stones is significant, on the order of 50%, though I don't remember where that number came from (I'm sure it was some pamphlet from my urologist's office, sponsored by the association of healthy urinary somethingorothers).

Abnormal means high; prevention mechanisms range from dietary (avoiding purines, eating cherries and dark berries) to medicinal (allopurinol, see gout page)

Corrected the table headings (which were switched) for the solubility of uric acid and urates. The solubility in boiling water is greater than in cold water. To quote from the 9th Edition of the Merk index: Entry 8474, Acid salt of sodium urate (NaHUrate) "sol in about 1200 parts cold, 125 parts boiling water". Similarly, Entry 9538, Uric Acid "One gram dissolves in about 15,000 parts cold water, about 2000 parts boiling water;" Sciencebookworm (talk) 19:14, 2 September 2011 (UTC)[reply]

silly question

this might be silly, but is uric acid ever an ingredient in toothpaste? or anything else that humans might consume?? Rachel Ayres 02:56, 16 December 2006 (UTC)[reply]

hi rachel i recently added a little section on foods that can elevate uric acid because they contain high purine levels, not sure which foods or items such as toothpaste might contain actual uric acid. i did find this though:

U Urea. Carbamide. Excreted from urine and other bodily fluids. In deodorants, ammoniated dentrifices, mouthwashes, hair colorings, hand creams, lotions, shampoos, etc. Used to "brown" baked goods, such as pretzels. Derivatives: Imidazolidinyl Urea, Uric Acid. Alternatives: synthetics.

Uric Acid. (See Urea.)

[1]

thank you very much for the info, I did a bit more research (there is some good info on the urea page) and I am not certain, but believe that it is likely most urea or uric acid used in common products (deoderant, pretzels etc.) is synthetic.

but if anyone has different info please pass it on!!

Rachel Ayres 23:22, 24 December 2006 (UTC)[reply]

question for beetstra

hi there what did you mean about RV to (long number) and referencing popups and removal of data? could you please clarify that comment, i'd like to know exactly what happened there, thanks.—Preceding unsigned comment added by 129.97.39.125 (talk • contribs)

I am sorry, without a link it is very difficult for me to say what you refer to, I probably reverted an edit, but I haven't reverted it on uric-acid. Could you please clarify. By the way, if you want to contact a person, it is easier to ask them on their talk page. --Dirk Beetstra ^{T C} 17:38, 12 January 2007 (UTC)[reply]

three year of pain

i want to say that i had suffered a lot because of this dan uric acid technical jargons have no meaning for me what i want is that please someone just let me know what causes this in very layman terms and yes which body part might be getting damaged due to this what kind of food are available to trackle this disease and apart from that purine stuff ok..... mail at [REMOVED] —The preceding unsigned comment was added by 208.49.241.227 (talk) 08:21, 9 April 2007 (UTC).[reply]

Try this article for a list of foods that are bad for someone with high uric acid. WhatamIdoing (talk) 07:34, 22 January 2008 (UTC)[reply]

diagram

can someone please add a lewis dot diagram to the top of this article, those coloured spheres are not very useful Preceding unsigned comment added by 121.79.12.115 (talk) 11:15, 23 October 2007 (UTC)[reply]

Or a ball-and-stick model, or even just a skeletal formula. I had to look up purine before I could understand the space-filling diagram. 73.53.44.165 (talk) 15:10, 31 May 2014 (UTC)[reply]

Why Acid

Why is it called an acid when there are so many amino components or R-N-R analogues? —Preceding unsigned comment added by Jokem (talk • contribs) 19:04, 13 March 2008 (UTC)[reply]

It is a weak organic acid. I.e., it dissociates so that protons (hydrogen atoms) come off in solution.Pproctor (talk) 20:50, 24 March 2008 (UTC)[reply]

Thanks, but that does not answer why it does this. Amino groups are normally proton acceptors, not donors. Very strange. Jokem (talk) 15:21, 26 March 2008 (UTC)[reply]

Amino groups that are not conjugated accept protons by using their lone pair of electrons to bond to the proton. But in the case of uric acid (and many other molecules with conjugated nitrogen atoms), the lone pair on nitrogen is delocalised. Consequently, these electrons are lower in energy (more stable, less reactive) and do not accept protons. A simpler example of the effect is found in amides, which unlike amines, are not basic.

As for the acidity, this paper gives details. They calculate that uric acid tautomerises from the structure shown in the article (triketo) to one that has an -OH group. This OH group then loses a proton.

Ben (talk) 17:34, 21 September 2008 (UTC)[reply]

46

if my uric acid in my blood above 46mg.so what can somehting attach my body?? —Preceding unsigned comment added by 60.49.195.154 (talk) 01:11, 16 July 2008 (UTC)[reply]

Disambiguate medical issues

The section Medical issues needs to be disambiguated into causes and consequences. Eg, gout is not a cause of hyperuricemia, and hyperuricemia usually does not cause gout. --Una Smith (talk) 16:17, 25 October 2008 (UTC)[reply]

Disambiguate uric acid and urate

Some medical papers indicate that crystal inhibitors with potential as therapies for gout have different and sometimes contradictory effects on uric acid and urate crystals. So, an explanation of the differences between these crystals would be helpful. --Una Smith (talk) 22:32, 30 October 2008 (UTC)[reply]

Sea salt?!

from the article: "Sources of uric acid

   * In many instances, people have elevated uric acid levels for hereditary reasons.
Diet may also be a factor; eating large amounts of sea salt can cause increased levels of uric acid.
(Medical consultation is recommended before using large quantities of sea salt in daily cooking.)"

There is no citation for this dubious assertion.

This "fact" makes no sense. Sea salt is not a source of uric acid. Sea salt is unrelated to hereditary reasons.

As far as I know, sea salt contains NaCl and not much else. Is there some minor constituent of sea salt that raises uric acid? What is it.

The reference to sea salt probably should go. 69.226.105.138 (talk) —Preceding undated comment added 17:16, 31 August 2009 (UTC).[reply]

Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

Hi I've just come from Gout where I'm compiling Potential Pathophysiological Mechanisms of Gout Inevitably it brought me here.

I have developed content that may be of interest here.

The protein metabolic waste product Uric acid that is excreted by the kidney and gut has generally been viewed as relatively unimportant. Recently it has been discovered that uric acid is not biologically inert being both a pro- and anti-oxidant and may act as a neurostimulant, an activator of the innate immune responses and induce inflammation. It has been proposed that uric acid has a key role in the foraging response associated with starvation and fasting in primates and that that may be a complex interplay between fructose, uric acid and vitamin C. Fructose and uric acid stimulate the foraging response and vitamin C suppresses it. [2] —Preceding unsigned comment added by Nnoddy (talk • contribs) 09:30, 2 March 2010 (UTC)[reply]

--Nnoddy (talk) 10:43, 2 March 2010 (UTC)[reply]

I am trying to respond to this comment. I hope I'm doing it right, but I'm new to Wikipedia Talk, so please forgive me if I'm not. I found this info very interesting. Could it be included in the article? (Keeping it very close to what the research says.) Thanks! --BetseyTrotwood (talk) 21:20, 7 April 2014 (UTC)[reply]

Use in Agriculture as a Fertilizer / Other industrial applications

Hi I'm not sure if I missed this in the article but perhaps should be included? I saw a big emphasis on human physiology / medical aspects and very little on other topics. Thank you. —Preceding unsigned comment added by 190.103.43.117 (talk) 06:29, 3 June 2010 (UTC)[reply]

Hello again. Just realized that "UREA" is a very different compound from "URIC ACID"; They are only similar in name. There is also an article on "URINE" that discusses fertilizer applications. I also understand that these compounds are used to manufacture certain substances that are later combined into plastics such as Bakelite. In short, a far more complex topic than I had originally thought. Thank you. —Preceding unsigned comment added by 201.208.86.79 (talk) 16:03, 9 June 2010 (UTC)[reply]

Urate

Although the article discusses urates, I have removed urate as a synonym from the intro because they are not the same (acid vs. salt of the acid). If someone feels strongly about its inclusion I recommend a more verbose phrase that acknowledges they are not identical but "cognates." --Belg4mit (talk) 01:02, 19 March 2011 (UTC)[reply]

I added it back myself, alongside acid urate and a reference to kidney stones. Someone may want to expand on the kidney stone link (eating disorders, genetics, diet). --Belg4mit (talk) 01:23, 19 March 2011 (UTC)[reply]

Sucrose

A meta-analysis I included in the article says "Fructose is also the only sugar able to increase blood uric acid concentrations". ~~That would suggest the association with sucrose mentioned in this article is inaccurate.~~ Lambanog (talk) 20:21, 23 April 2011 (UTC)[reply]

Never mind—sucrose contains fructose. Lambanog (talk) 16:42, 24 April 2011 (UTC)[reply]

Parking

Due to concerns raise above I'll move some stuff here until sources can be found to verify.

Eating large amounts of sea salt can cause increased levels of uric acid.^{[citation needed]} (Medical consultation is recommended before using large quantities of sea salt in daily cooking.^{[citation needed]})

Lambanog (talk) 16:42, 24 April 2011 (UTC)[reply]

"More soluble" than what?

Considering this sentence under "Gout": "One treatment for gout, in the 19th century, had been administration of lithium salts;[31] lithium urate is more soluble." "More soluble" than....? I think this needs to be re-worded; I was always taught never to use the comparative unless you're actually comparing two or more things.

How about:

" ... because lithium urate is more soluble than naturally occurring uric acid in the body, it was mistakenly believed that it would relieve gout."

Or perhaps we could identify what lithium urate is specifically more soluble than. I would think ammonium urate? (I'm not sure about that, but the chart above does lead to that implication.)

As a reference for this, one could cite the following: https://cen.acs.org/articles/91/i26/Lithium-Treating-Gout.html

Fraenkel, Gideon. Letters, "Lithium For Treating Gout," Chemical & Engineering News. Volume 91, Issue 26, p. 2, July 1, 2013.

(I don't know the correct citation format yet for Wikipedia, so that's probably wrong above, but all the info is there.)

In this letter, Dr. Fraenkel writes: "Needless to say, gout symptoms were not alleviated by lithium salts...."

--BetseyTrotwood (talk) 21:13, 7 April 2014 (UTC)[reply]

Speculation about cognition

I wonder if the association with cognition may be due to uridine, which then can be more safely raised in normal people by a triacetyluridine supplement. --IO Device (talk) 00:21, 10 August 2014 (UTC)[reply]

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Rodents

Since MSU and uric acid are studied in rodents and one study in mice is cited, why are no rodent data presented, while all discussion of the topics relate to either humans, or in nonhumans other than rodents? MaynardClark (talk) 04:44, 6 October 2015 (UTC)[reply]

I'm not familiar with the studies you're referring to, but I would imagine that these were studies where rodents were used as models for the chemical's effect on humans, rather than studying problems that naturally occur in rodents. Of course, if these studies provide useful information, then it would be good if that information was added to that article. Attaboy (talk) 17:56, 6 October 2015 (UTC)[reply]